Aripiprazole two-month long-acting injectable may increase time to readmission compared to aripiprazole one-month in patients with schizophrenia and schizoaffective disorder [0.03%]
注射用阿立哌唑长效针剂可能使精神分裂症和分裂情感障碍患者再次住院的时间间隔增加
Sean T Lynch,Kathryn Brooke Renard,Angelo I Chaia et al.
Sean T Lynch et al.
Objective: Schizophrenia and schizoaffective disorder are primarily treated with antipsychotic medications, including long-acting injectables (LAIs) which help reduce relapse/readmission. New LAIs have longer duration of ...
Genetic susceptibility of cardiometabolic outcomes in schizophrenia spectrum disorders [0.03%]
精神分裂症谱系障碍中心代谢结局的遗传易感性
Chenxu Zhao,Bochao Lin,Elnaz Naderi et al.
Chenxu Zhao et al.
Patients with schizophrenia spectrum disorders (SSDs) have a higher risk for post-diagnostic cardiometabolic comorbidities. While antipsychotic use partly explains this, the contribution of genetic susceptibility remains unclear. We investi...
Reframing schizophrenia as a neurodevelopmental syndrome: The scientific and social imperative [0.03%]
将精神分裂症重新定义为神经发育综合征：科学和社交的必要性
Arundati Nagendra,Raquelle Mesholam-Gately,Jason Shafrin et al.
Arundati Nagendra et al.
Background: Schizophrenia is traditionally classified as a serious mental illness (SMI), emphasizing chronicity and disability. However, growing evidence supports that it also shows features of a neurodevelopmental syndro...
Ten-year risk prediction models for atherosclerotic cardiovascular disease in Chinese patients with schizophrenia-spectrum disorders: A population-based cohort study [0.03%]
中国分裂型障碍患者动脉粥样硬化性心血管疾病10年发病风险预测模型：基于人群的队列研究
Jennifer Yee-Man Tang,Gloria Hoi-Yan Wong,Huiquan Zhou et al.
Jennifer Yee-Man Tang et al.
Background: Existing atherosclerotic cardiovascular disease (ASCVD) prediction models developed for the general population may inaccurately estimate risk in Chinese patients with schizophrenia-spectrum disorders. This und...
Association between Toxoplasma gondii IgG seropositivity and schizophrenia: A case-control study in Colombia [0.03%]
弓形虫IgG阳性与精神分裂症相关性的病例对照研究——一项关于哥伦比亚地区的研究
Juan F Cano,Sebastián Galindo-Pita,Daniela Méndez et al.
Juan F Cano et al.
Whether Toxoplasma gondii contributes to schizophrenia remains debated. We evaluated this association using a matched case-control design with two comparison groups and examined serotype distribution and clinical/cognitive correlates. We in...
Psychedelics for treatment of negative symptoms and depressive symptoms in schizophrenia spectrum disorder: A narrative review [0.03%]
用于治疗精神分裂症谱系障碍的负性症状和抑郁症状的迷幻剂：叙述性综述
Michel Sabé,Paul Grof,Nathan B Sackett et al.
Michel Sabé et al.
Serotonergic psychedelics are re-emerging as therapeutic candidates across psychiatry, particularly for treatment-resistant depression. Their rapid and sustained antidepressant effects, alongside evidence for neuroplastic, dopaminergic, and...
Schizoaffective disorder - A conglomerated disorder that needs an amalgamation of ideas [0.03%]
分裂情感障碍-一种需要整合思想的综合症候群
Gurubhaskar Shivakumar,Kinga Szymaniak,Erica Bell et al.
Gurubhaskar Shivakumar et al.
The continued use of schizoaffective disorder (SAD) as a diagnostic category remains puzzling, given its well-documented lack of validity, reliability, and clinical utility. In practice, the reflexive application of this diagnosis to patien...
Low incidence of extrapyramidal symptoms following treatment with a muscarinic agonist medication for schizophrenia [0.03%]
用于治疗精神分裂症的毒蕈碱激动剂药物治疗后出现锥体外系症状的风险低
Steven D Targum,Carolyn Watson,Amy Claxton et al.
Steven D Targum et al.
Background: Extrapyramidal symptoms (EPS) have long been associated with the use of antipsychotic medications. The etiology of EPS has often been attributed to dopamine D2 receptor antagonism. Most currently available ant...
Why is it hard to assess thought disorder? Clarifying the third domain of psychosis [0.03%]
为何难以评估思维障碍？澄清精神病的第三个领域
L Palaniyappan,V S Sreeraj,G Venkatasubramanian et al.
L Palaniyappan et al.
Formal Thought Disorder (FTD) presents psychiatry's central paradox: it is one of the robust predictors of poor outcomes and polygenic risk in psychosis yet remains poorly defined and rarely measured clinically. We systematically reviewed 5...
Negative symptoms and resting state functional connectivity: Leveraging ecological momentary assessment and individual-specific techniques [0.03%]
负性症状和静息态功能连接性：利用生态瞬时评估法及个体特异性技术
Nada Dalloul,Sridhar Kandala,Erin Moran et al.
Nada Dalloul et al.
There are indications that motivational deficits in psychotic and mood disorders are related to differences in functional connectivity. However, the literature is mixed, partly due to the limitations of traditional methods in accounting for...