Methionine gamma lyase from Clostridium sporogenes increases the anticancer effect of doxorubicin in A549 cells and human cancer xenografts [0.03%]
来源于破伤风梭状芽孢杆菌的蛋氨酸伽玛裂解酶增强多柔比星对A549细胞和人移植瘤的抗癌效果
V S Pokrovsky,N Yu Anisimova,D Zh Davydov et al.
V S Pokrovsky et al.
The anti-cancer efficacy of methionine γ-lyase (MGL) from Clostridium sporogenes (C. sporogenes) is described. MGL was active against cancer models in vitro and in vivo. The calculated EC50 values for MGL were 4.4 U/ml for A549, 7.5 U/ml f...
Survival and tolerance to sorafenib in Child-Pugh B patients with hepatocellular carcinoma: a prospective study [0.03%]
巴弗氏分级B级肝细胞癌患者索拉非尼的耐受性和生存研究一项前瞻性研究
Cassia Regina Guedes Leal,Cristiane Magalhães,Daniel Barbosa et al.
Cassia Regina Guedes Leal et al.
Sorafenib has been widely used to treat unresectable hepatocellular carcinoma (HCC) but most studies have been done in Child-Pugh A (CP-A) patients with well-preserved liver function. We evaluated the overall survival (OS) and tolerance to ...
Clinical Trial
Investigational new drugs. 2018 Oct;36(5):911-918. DOI:10.1007/s10637-018-0621-x 2018
Phase II study of DFP-10917, a deoxycytidine analog, given by 14-day continuous intravenous infusion for chemotherapy-refractory advanced colorectal cancer [0.03%]
DPF-10917（脱氧胞苷类似物）连续静脉滴注14天治疗难治性晚期结直肠癌Ⅱ期临床研究
Amir Mehrvarz Sarshekeh,Henry Q Xiong,Kenzo Iizuka et al.
Amir Mehrvarz Sarshekeh et al.
Background DFP-10917 is a cytotoxic deoxycytidine analogue that causes DNA fragmentation, G2/M-phase arrest, and apoptosis. This agent has been shown to have antitumor activity against colorectal cancer (CRC) in preclinical studies and to b...
Clinical Trial
Investigational new drugs. 2018 Oct;36(5):895-902. DOI:10.1007/s10637-018-0615-8 2018
A phase Ib study of sonidegib (LDE225), an oral small molecule inhibitor of smoothened or Hedgehog pathway, in combination with docetaxel in triple negative advanced breast cancer patients: GEICAM/2012-12 (EDALINE) study [0.03%]
一项关于索拉非尼(LDE225)联合多西他赛治疗三阴性晚期乳腺癌患者的 Ib 期临床研究：GEICAM/2012-12（EDALINE）研究
Manuel Ruiz-Borrego,Begoña Jimenez,Silvia Antolín et al.
Manuel Ruiz-Borrego et al.
Up-regulation of the Hedgehog (Hh) pathway is implicated in the genesis of a wide range of tumors including triple negative breast cancer (TNBC). Sonidegib is a potent and selective oral inhibitor of Smo, a key component of the Hh signaling...
Clinical Trial
Investigational new drugs. 2019 Feb;37(1):98-108. DOI:10.1007/s10637-018-0614-9 2019
Inhibition of SHP2 by new compounds induces differential effects on RAS/RAF/ERK and PI3K/AKT pathways in different cancer cell types [0.03%]
新型化合物抑制SHP2使不同癌细胞类型中的RAS/RAF/ERK和PI3K/AKT通路产生不同的效应
Cijo George Vazhappilly,Ekram Saleh,Wafaa Ramadan et al.
Cijo George Vazhappilly et al.
Kinases and phosphatases are important players in growth signaling and are involved in cancer development. For development of targeted cancer therapy, attention is given to kinases rather than phosphatases inhibitors. Src homology region 2 ...
Proliferative CD8(+) PD-1(+) T-cell infiltration in a pembrolizumab-induced cutaneous adverse reaction [0.03%]
帕博利珠单抗致皮肤不良反应中增生的CD8(+ )PD-1(+)T细胞浸润
Kei Kunimasa,Taiki Isei,Harumi Nakamura et al.
Kei Kunimasa et al.
Pembrolizumab, a humanized monoclonal immunoglobulin (Ig) G4 antibody that is directed against the human cell surface receptor PD-1, is a PD-1 pathway inhibitor that has been approved to treat various malignant diseases, including advanced ...
Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells [0.03%]
抗肿瘤活性大戟醇通过诱导自噬增强胶质母细胞瘤细胞对替莫唑胺的敏感性
Viviane A O Silva,Marcela N Rosa,Vera Miranda-Gonçalves et al.
Viviane A O Silva et al.
Glioblastoma (GBM) is the most frequent and aggressive type of brain tumor. There are limited therapeutic options for GBM so that new and effective agents are urgently needed. Euphol is a tetracyclic triterpene alcohol, and it is the main c...
Alteration of benzo(a)pyrene biotransformation by resveratrol in ApcMin/+ mouse model of colon carcinogenesis [0.03%]
白藜茋对ApcMin/+)小鼠结肠癌变模型中苯并(a)芘代谢转化的影响
Ashley C Huderson,P V Rekha Devi,Mohammad S Niaz et al.
Ashley C Huderson et al.
Epidemiological surveys have revealed that environmental and dietary factors contribute to most of the human cancers. Our earlier studies have shown that resveratrol (RVT), a phytochemical reduced the tumor number, size and incidence of dys...
Dual targeting of bromodomain-containing 4 by AZD5153 and BCL2 by AZD4320 against B-cell lymphomas concomitantly overexpressing c-MYC and BCL2 [0.03%]
AZD5153和AZD4320通过双重靶向溴结构域蛋白4和B细胞淋巴瘤2来针对同时过度表达c-MYC和B细胞淋巴瘤2的B细胞淋巴瘤
Tomoko Takimoto-Shimomura,Taku Tsukamoto,Saori Maegawa et al.
Tomoko Takimoto-Shimomura et al.
Despite the recent therapeutic progress, the prognoses of diffuse large B-cell lymphomas (DLBCLs) that concomitantly overexpress c-MYC and BCL2, i.e., double hit lymphoma (DHL) and double expressing lymphoma (DEL), remain poor. This study e...
The poly (ADP-ribose) polymerase inhibitor rucaparib suppresses proliferation and serves as an effective radiosensitizer in cervical cancer [0.03%]
聚(腺苷二磷酸核糖)聚合酶抑制剂rucaparib可抑制宫颈癌细胞增殖并具有放射增敏作用
Mei Tang,Qiuli Liu,Leyuan Zhou et al.
Mei Tang et al.
Objectives Our goal was to investigate the effects of rucaparib on the proliferation of cervical cancer cells and sensitivity to radiotherapy. Methods We used the human cervical cancer cell lines Hela and Siha and evaluated their viability ...