A phase I study of the vascular endothelial growth factor inhibitor Vatalanib in combination with Pemetrexed disodium in patients with advanced solid tumors [0.03%]
贝伐单抗联合培美曲塞治疗晚期恶性实体瘤的I期临床研究
Fen Wang,Julian Molina,Daniel Satele et al.
Fen Wang et al.
Introduction Vatalanib is an oral receptor tyrosine kinase inhibitor that blocks all known VEGF, PDGF, and c-Kit receptors. This phase I study evaluated the safety, tolerability, and biologic activity of the combination of vatalanib with pe...
Clinical Trial
Investigational new drugs. 2019 Aug;37(4):658-665. DOI:10.1007/s10637-018-0690-x 2019
Lurbinectedin (PM01183), a selective inhibitor of active transcription, effectively eliminates both cancer cells and cancer stem cells in preclinical models of uterine cervical cancer [0.03%]
Lurbinectedin（PM01183），一种有效的转录抑制剂，可在子宫颈癌的临床前模型中有效消除癌细胞和癌症干细胞
Eriko Yokoi,Seiji Mabuchi,Kotaro Shimura et al.
Eriko Yokoi et al.
Objective The objective of this study was to evaluate the antitumor effects of lurbinectedin on cervical cancer with a special focus on its effects on cancer stem cells (CSCs). Methods Using two cervical cell lines (ME180 and CaSki cells), ...
The bispecific anti-CD3 × anti-CD155 antibody mediates T cell immunotherapy for human prostate cancer [0.03%]
双特异性的抗CD3×抗CD155抗体通过T细胞免疫疗法治疗人类前列腺癌
Huijun Zhao,Juan Ma,Ting Lei et al.
Huijun Zhao et al.
Expression of CD155 differs between tumor and normal tissues, and high expression of this molecule can promote tumor metastasis. Here, we investigate whether CD155 can serve as a target for T cell-mediated immunotherapy of human prostate ca...
A novel humanized anti-PD-1 monoclonal antibody potentiates therapy in oral squamous cell carcinoma [0.03%]
一种新型人源化抗PD-1单克隆抗体可增强对口腔鳞状细胞癌的治疗作用
Y Cai,Fei Wang,Q Liu et al.
Y Cai et al.
Currently, immune checkpoint inhibitors have been shown to extend the survival of many cancer patients. However, few studies have focused on immune checkpoint inhibition for the treatment of patients with oral squamous cell carcinoma (OSCC)...
Chemotherapy in pregnancy: exploratory study of the effects of paclitaxel on the expression of placental drug transporters [0.03%]
妊娠期化疗：紫杉醇对胎盘药物转运蛋白表达影响的探索性研究
Paul Berveiller,Olivier Mir,Séverine A Degrelle et al.
Paul Berveiller et al.
Introduction The use of paclitaxel in pregnant cancer patients is feasible in terms of fetal safety, but little is known about the effects of paclitaxel on the placenta. Using three experimental models, we aimed to assess the effects of pac...
Advanced development of ErbB family-targeted therapies in osteosarcoma treatment [0.03%]
针对骨肉瘤治疗的ErbB家族靶向疗法的进一步发展
Wei Wang,Hua-Fu Zhao,Teng-Fei Yao et al.
Wei Wang et al.
Osteosarcoma (OS) is the most common primary aggressive and malignant bone tumor. Newly diagnostic OS patients benefit from the standard therapy including surgical resection plus radiotherapy and neoadjuvant chemotherapy (MAP chemotherapy: ...
Corticosteroid switch in heavily pre-treated castration-resistant prostate cancer patients progressed on abiraterone acetate plus prednisone [0.03%]
阿比特龙联合泼尼松治疗进展的多线治疗去势抵抗性前列腺癌患者中的皮质类固醇转换疗法
Giandomenico Roviello,Roberto Petrioli,Alberto Bonetta et al.
Giandomenico Roviello et al.
The aim of this retrospective study is to evaluate the activity and safety of a steroidal switch from prednisone to dexamethasone in patients with advanced, heavily pre-treated, castration-resistant prostate cancer (CRPC) who progressed on ...
Antitumor evaluation of novel phenothiazine derivatives that inhibit migration and tubulin polymerization against gastric cancer MGC-803 cells [0.03%]
一类新型吩噻嗪类衍生物通过抑制胃癌MGC-803细胞迁移及微管聚合而发挥抗肿瘤活性的研究
Nan Liu,Zhe Jin,Jing Zhang et al.
Nan Liu et al.
Two novel series of 1,2,3-triazole-phenothiazine hybrids and dithiocarbamate-phenothiazine hybrids were designed and synthesized by molecular hybridization strategy. Their antiproliferative activity against three gastric cancer cell lines (...
Correction to: Phase I study combining the aurora kinase a inhibitor alisertib with mFOLFOX in gastrointestinal cancer [0.03%]
Correction to：alisertib联合mFOLFOX治疗胃肠癌I期临床研究
Laura W Goff,Nilofer S Azad,Stacey Stein et al.
Laura W Goff et al.
The authors would like to note that the investigator affiliations have been corrected to reflect the actual affiliations of each author. The authors would also like to note an amendment to the first name of the second author. Nilo Azad was ...
Published Erratum
Investigational new drugs. 2018 Dec;36(6):1158. DOI:10.1007/s10637-018-0679-5 2018
Relationship between expression of XRCC1 and tumor proliferation, migration, invasion, and angiogenesis in glioma [0.03%]
XRCC1表达与胶质瘤肿瘤增殖、迁移、侵袭及血管生成的关系研究
Peng-Jin Mei,Jin Bai,Fa-An Miao et al.
Peng-Jin Mei et al.
Recently, XRCC1 polymorphisms were reported to be associated with glioma in Chinese population. However, only a few studies reported on the XRCC1 expression, and cancer progression. In this study, we investigated whether XRCC1 plays a role ...