Switch maintenance therapy with S-1 after induction therapy with carboplatin and nanoparticle albumin-bound paclitaxel in advanced lung squamous cell carcinoma [0.03%]
卡铂联合白蛋白结合型紫杉醇诱导治疗后继用苏特瑞维持治疗晚期肺鳞癌的Ⅱ期临床研究
Norimichi Akiyama,Masato Karayama,Naoki Inui et al.
Norimichi Akiyama et al.
Background Optimal maintenance therapy for lung squamous cell carcinoma (SCC) has not been established. The aim of this study was to evaluate the efficacy and safety of switch maintenance therapy with S-1, an oral fluoropyrimidine, after in...
GNS561, a new lysosomotropic small molecule, for the treatment of intrahepatic cholangiocarcinoma [0.03%]
新型溶酶体化合物GNS561治疗肝内胆管癌研究
Sonia Brun,Firas Bassissi,Cindy Serdjebi et al.
Sonia Brun et al.
Among the acquired modifications in cancer cells, changes in lysosomal phenotype and functions are well described, making lysosomes a potential target for novel therapies. Some weak base lipophilic drugs have a particular affinity towards l...
An orally antitumor chalcone hybrid inhibited HepG2 cells growth and migration as the tubulin binding agent [0.03%]
一种抗肿瘤口服化合物抑制肝癌细胞增殖和迁移并作为潜在的微管结合剂发挥作用
Wang Yan,Chen Xiangyu,Li Ya et al.
Wang Yan et al.
Liver cancer is a kind of high mortality cancer due to the difficulty of early diagnosis. It is necessary to develop the anticancer agents to treat liver cancer. Here, a novel chalcone derivative was synthesized and evaluated for anticancer...
LEF1-AS1 contributes to proliferation and invasion through regulating miR-544a/ FOXP1 axis in lung cancer [0.03%]
LEF1-AS1通过调节miR-544a/FOXP1轴促进肺癌的增殖和侵袭
Ansheng Wang,Chengling Zhao,Yuan Gao et al.
Ansheng Wang et al.
Long non-coding RNAs (lncRNAs) are increasingly recognized as important regulators in tumor development. This study aims to investigate the potential role oflncRNALEF1-AS1, in the progression of lung cancer. Quantitative real-time PCR (qRT-...
Delineation of proapoptotic signaling of anthracene-shelled M2L4 metallacapsules and their synergistic activity with curcumin in cisplatin-sensitive and resistant tumor cell lines [0.03%]
用于敏感和耐药肿瘤细胞系的苊烯壳修饰的M2L4金属笼的促凋亡信号作用及其与姜黄素的协同活性研究
Rositsa Mihaylova,Anife Ahmedova,Denitsa Momekova et al.
Rositsa Mihaylova et al.
Since the introduction of cisplatin into clinical practice a few decades ago, the topic of metal-based drugs has expanded significantly. Recent examples emphasize on metallosupramolecules as an emerging class of compounds with diverse prope...
A phase I study of the antibody drug conjugate ASG-5ME, an SLC44A4-targeting antibody carrying auristatin E, in metastatic castration-resistant prostate cancer [0.03%]
靶向于SLC44A4的携带苯丙氨酸 mustard衍生物的抗体药物偶联物ASG-5ME在转移性去势抵抗性前列腺癌中的I期研究
Deaglan McHugh,Mario Eisenberger,Elisabeth I Heath et al.
Deaglan McHugh et al.
Background Antibody drug conjugates (ADC) offer the potential of maximizing efficacy while minimizing systemic toxicity. ASG-5ME, an SLC44A4-targeting antibody carrying monomethyl auristatin E (MMAE), a microtubule-disrupting agent, was inv...
Clinical outcomes of advanced stage cancer patients treated with sequential immunotherapy in phase 1 clinical trials [0.03%]
一线临床试验中晚期癌症患者序贯免疫治疗的临床结果
Dylan J Martini,Yuan Liu,Julie M Shabto et al.
Dylan J Martini et al.
Background Given the increasing number of available immunotherapeutic agents, more patients are presenting after failing immunotherapy in need of new treatment options. In this study, we investigated the clinical outcomes of patients treate...
Modified ingenol semi-synthetic derivatives from Euphorbia tirucalli induce cytotoxicity on a large panel of human cancer cell lines [0.03%]
由Euphorbia tirucall提取的 Modified ingenol半合成衍生物可诱导多种人类癌细胞系中毒性反应
Viviane A O Silva,Marcela N Rosa,Olga Martinho et al.
Viviane A O Silva et al.
The latex from Euphorbia tirucalli is used in Brazil as a folk medicine for several diseases, including cancer. Recently, we showed a cytotoxic activity of E. tirucalli euphol in a wide range of cancer cell lines. Moreover, we showed that e...
Apatinib, a novel VEGFR inhibitor plus docetaxel in advanced lung adenocarcinoma patients with wild-type EGFR: a phase I trial [0.03%]
阿帕替尼联合多西他赛治疗野生型表皮生长因子受体肺腺癌患者的I期临床试验研究
Jian-Chun Duan,Zhi-Jie Wang,Lin Lin et al.
Jian-Chun Duan et al.
Background This phase I trial was primarily conducted to determine the maximum tolerated dose (MTD) of apatinib combined with docetaxel in advanced lung adenocarcinoma patients with wild-type EGFR who have failed to first-line platinum-base...
Lopinavir-NO, a nitric oxide-releasing HIV protease inhibitor, suppresses the growth of melanoma cells in vitro and in vivo [0.03%]
一种释放一氧化氮的HIV蛋白酶抑制剂洛匹那韦-NO可体内和体外抑制黑色素瘤细胞生长
Svetlana Paskas,Emanuela Mazzon,Maria Sofia Basile et al.
Svetlana Paskas et al.
We generated a nitric oxide (NO)-releasing derivative of the anti-HIV protease inhibitor lopinavir by linking the NO moiety to the parental drug. We investigated the effects of lopinavir and its derivative lopinavir-NO on melanoma cell line...