Ludovica Taglieri,Francesco Saccoliti,Alice Nicolai et al.
Ludovica Taglieri et al.
Recently, some synthetic nitrogen-based heterocyclic molecules, such as PJ34, have shown pronounced antitumor activity. Therefore, we designed and synthesized new derivatives characterized by a nitrogen-containing scaffold and evaluated the...
The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer [0.03%]
棘 fungal 生物合成代谢抑制剂neticonazole通过抑制外泌体分泌而抑制肠道菌群失调诱导的结直肠癌肿瘤发生
Lei Gu,Yidong Xu,Wangyan Xu et al.
Lei Gu et al.
Colorectal cancer (CRC) is the most frequently encountered malignancy associated with the rectum or colon, and accumulating evidences have implicated intestinal dysbacteriosis (IDB, disruption of gut microbiome) and exosomes in the patholog...
Tubulin colchicine site binding agent LL01 displays potent antitumor efficiency both in vitro and in vivo with suitable drug-like properties [0.03%]
秋水仙碱位点结合剂LL01具有良好的药物类属性及体内外抗肿瘤活性
Jing-De Wu,Ying-Jie Cui,Yi-Gang Zhou et al.
Jing-De Wu et al.
Through rational drug design, we previously identified an indenoprazole derivative, 2-(6-ethoxy-3-(3-ethoxyphenylamino)-1-methyl-1,4-dihydroindeno[1,2-c]pyrazol-7-yloxy)acetamide (LL01), as a potent tubulin polymerization inhibitor targetin...
Cytotoxicity of [HuArgI (co)-PEG5000]-induced arginine deprivation to ovarian Cancer cells is autophagy dependent [0.03%]
羟基_ARGI-聚乙二醇诱导的卵巢癌细胞精氨酸剥夺的细胞毒性作用依赖于自噬反应
Ghenwa Nasreddine,Mirvat El-Sibai,Ralph J Abi-Habib
Ghenwa Nasreddine
In this study, we assess arginine auxotrophy in ovarian cancer cells and attempt to target them using arginine deprivation induced by a pegylated recombinant human Arginase I cobalt [HuArgI (Co)-PEG5000]. Ovarian cancer cells were sensitive...
Knockdown of FBXO22 inhibits melanoma cell migration, invasion and angiogenesis via the HIF-1α/VEGF pathway [0.03%]
FBXO22基因敲低通过HIF-1α/VEGF信号通路抑制黑色素瘤细胞迁移、侵袭及新生血管生成作用研究
Yufan Zheng,Hairong Chen,Yang Zhao et al.
Yufan Zheng et al.
F-box proteins, a type of substrate-recognition complexes consisting of SKP1-cullin 1-F-box protein (SCF) E3 ligase, can critically affect many cellular processes because of the ubiquitylation and subsequent degradation of target proteins. ...
A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody-drug conjugate, in patients with breast cancer and other advanced solid tumors [0.03%]
一项I期、剂量递增研究：在乳腺癌和其他晚期实体瘤患者中，PF-06650808（一种抗Notch3抗体药物偶联物）的研究
Lee S Rosen,Robert Wesolowski,Raffaele Baffa et al.
Lee S Rosen et al.
Background PF-06650808 is a novel anti-Notch3 antibody-drug conjugate (ADC) able to deliver an auristatin-based cytotoxic payload to target cells. In this first-in-human, dose-finding, phase I study (NCT02129205), we investigated safety, ph...
Ramucirumab as a second line therapy for advanced HCC: a significant achievement or a wasted opportunity for personalised therapy? [0.03%]
对于晚期肝癌而言雷莫卢单抗作为二线治疗药物是重大的成就还是浪费了进行个体化治疗的机会？
Giandomenico Roviello,Navid Sohbani,Roberto Petrioli et al.
Giandomenico Roviello et al.
The second line treatment of hepatocellular carcinoma (HCC) has recently become an exciting area of interest since new emerging options have demonstrated survival benefits versus placebo. Unfortunately, predictive biomarkers are unavailable...
Identification of inhibitors of the polo-box domain of polo-like kinase 1 from natural and semisynthetic compounds [0.03%]
从天然产物和半合成化合物中筛选 Polo 样激酶 1 的 Polobox 结构域抑制剂
Sara Abdelfatah,Edmond Fleischer,Anette Klinger et al.
Sara Abdelfatah et al.
PLK1 has an important role in the regulation of cell cycle and represents an important target for cancer treatment. This enzyme belongs to the Polo-like kinases family, which is characterized by a regulatory domain named Polo-box domain (PB...
Novel palladium (II) complexes with tetradentate thiosemicarbazones. Synthesis, characterization, in vitro cytotoxicity and xanthine oxidase inhibition [0.03%]
四齿含硫半卡比配体钯(II)配合物的合成、表征及其抗肿瘤活性和黄嘌呤氧化酶抑制作用研究
Dilşad Özerkan,Onur Ertik,Buşra Kaya et al.
Dilşad Özerkan et al.
In vitro cytotoxicity and xanthine oxidase inhibition capabilities were investigated for five palladium (II) chelate complexes. The palladium complexes were synthesized by starting from S-alkyl-thiosemicarbazones where the alkyl component i...
Eribulin, trastuzumab, and pertuzumab as first-line therapy for patients with HER2-positive metastatic breast cancer: a phase II, multicenter, collaborative, open-label, single-arm clinical trial [0.03%]
艾日布林、曲妥珠单抗和帕妥珠单抗用于HER2阳性转移性乳腺癌一线治疗的Ⅱ期临床试验
Kenichi Inoue,Jun Ninomiya,Tsuyoshi Saito et al.
Kenichi Inoue et al.
Purpose To examine the efficacy and safety of triple therapy with eribulin, trastuzumab, and pertuzumab in patients with HER2-positive metastatic breast cancer (MBC) who never received any prior therapy in the first-line metastatic/advanced...