Emodin, a natural anthraquinone, suppresses liver cancer in vitro and in vivo by regulating VEGFR2 and miR-34a [0.03%]
天然蒽醌大黄素通过调节VEGFR2和miR-34a抑制肝癌的发展
Jianguo Bai,Jianfei Wu,Ruifeng Tang et al.
Jianguo Bai et al.
The pharmacokinetic (PK) and potential effects of Emodin on liver cancer were systematically evaluated in this study. Both the intragastric administration (i.g.) and hypodermic injection (i.h.) of Emodin exhibited a strong absorption (absor...
Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma [0.03%]
Notch抑制剂crenigacestat(LY3039478)在高级别或转移性腺样囊性癌的1期临床开放标签试验扩展队列中的安全性及疗效研究
C Even,U Lassen,J Merchan et al.
C Even et al.
Background Deregulated Notch signaling is implicated in multiple cancers. The phase I trial (I6F-MC-JJCA) investigated the safety and anti-tumor activity of crenigacestat (LY3039478), a selective oral Notch inhibitor, in an expansion cohort...
Correction to: A novel histone deacetylase inhibitor, CG200745, potentiates anticancer effect of docetaxel in prostate cancer via decreasing Mcl-1 and Bcl-XL [0.03%]
Correction to: 士的宁衍生物CG200745通过降低Mcl-1和Bcl-XL增强抗前列腺癌药物docetaxel的效果 novothesis
Jung Jin Hwang,Yong Sook Kim,Taelim Kim et al.
Jung Jin Hwang et al.
The blots of control and docetaxel for caspase-9, caspase-3, caspase-8, Bcl-XL, and tubulin in the Figure 4f were reused from Figure 4 of our previous paper published in Journal of Urology in 2010 ( https://doi.org/10.1016/j.juro.2010.07.03...
Published Erratum
Investigational new drugs. 2019 Aug;37(4):796. DOI:10.1007/s10637-019-00746-y 2019
Early depth of tumor shrinkage and treatment outcomes in non-small cell lung cancer treated using Nivolumab [0.03%]
纳武单抗治疗非小细胞肺癌的早期肿瘤缩小深度与治疗转归的关系研究
Hayato Kawachi,Daichi Fujimoto,Takeshi Morimoto et al.
Hayato Kawachi et al.
Background It would be useful to have criteria for predicting long-term treatment responses to immune checkpoint inhibitors (ICIs). Maximum depth of response correlates with treatment outcomes among patients receiving programmed death prote...
Observational Study
Investigational new drugs. 2019 Dec;37(6):1257-1265. DOI:10.1007/s10637-019-00770-y 2019
MicroRNA-101-3p suppresses proliferation and migration in hepatocellular carcinoma by targeting the HGF/c-Met pathway [0.03%]
microRNA-101-3p通过靶向HGF/c-Met途径抑制肝癌细胞增殖和迁移作用
Yang Liu,Juan Tan,Shuangyan Ou et al.
Yang Liu et al.
MicroRNAs are involved in each stage of tumor development. Activation of the hepatocyte growth factor (HGF)/c-Met axis facilitates the proliferation and migration of cancer cells, and the HGF/c-MET pathway provides potential targets for ant...
Cellular uptake evaluation of pentagamaboronon-0 (PGB-0) for boron neutron capture therapy (BNCT) against breast cancer cells [0.03%]
用于硼中子俘获疗法(PBNCT)的五聚甘氨肽包载硼化合物(PGB-0)在乳腺癌细胞中的摄取研究
Adam Hermawan,Ratna Asmah Susidarti,Ratna Dwi Ramadani et al.
Adam Hermawan et al.
Pentagamaboronon-0 (PGB-0), a curcumin analog compound, has been synthesized as a candidate of boron-carrier pharmaceutical (BCP) for boron neutron capture therapy (BNCT); however, this compound is poorly soluble in water. To improve its so...
Discovery and anticancer evaluation of a formononetin derivative against gastric cancer SGC7901 cells [0.03%]
一种形式松素衍生物的发现及其对胃癌细胞系SGC7901的抗肿瘤活性评价
Jian-Ning Yao,Xue-Xiu Zhang,Yan-Zhen Zhang et al.
Jian-Ning Yao et al.
Background Gastric cancer (GC) is the second most common cause of cancer-related death worldwide. Novel anticancer drugs against gastric cancer are urgently needed. Methods Compound 10 was designed and synthesized via a molecular hybridizat...
A first-in-human study of the novel metabolism-based anti-cancer agent SM-88 in subjects with advanced metastatic cancer [0.03%]
一种基于代谢的新型抗肿瘤药物SM-88在晚期转移性癌症患者中的首次人体研究
Jeanetta Stega,Marcus S Noel,Alexander G Vandell et al.
Jeanetta Stega et al.
Purpose SM-88 (D,L-alpha-metyrosine; racemetyrosine) is a novel anti-cancer agent, used with melanin, phenytoin, and sirolimus (SMK Therapy). This pilot first-in-human study characterized the safety, tolerability, and efficacy of SMK Therap...
Emodin induced necroptosis in the glioma cell line U251 via the TNF-α/RIP1/RIP3 pathway [0.03%]
大黄素通过TNF-α/RIP1/RIP3途径诱导胶质瘤U251细胞坏死性凋亡
Jiabin Zhou,Genhua Li,Guangkui Han et al.
Jiabin Zhou et al.
Emodin, an anthraquinone compound extracted from rhubarb and other traditional Chinese medicines, has been proven to have a wide range of pharmacological effects, such as anti-inflammatory, antiviral, and antitumor activities. Previous stud...
Correction to: Phase II study of sunitinib in Japanese patients with unresectable or metastatic, well-differentiated pancreatic neuroendocrine tumor [0.03%]
sunitinib治疗不可切除或转移性分化良好胰腺神经内分泌肿瘤的II期研究的更正公告
Tetsuhide Ito,Takuji Okusaka,Toshirou Nishida et al.
Tetsuhide Ito et al.
In the original publication of this article, the license subtype should be CC BY and not CC BY-NC.
Published Erratum
Investigational new drugs. 2019 Jun;37(3):591. DOI:10.1007/s10637-019-00757-9 2019