A phase II study of the orally administered negative enantiomer of gossypol (AT-101), a BH3 mimetic, in patients with advanced adrenal cortical carcinoma [0.03%]
AT-101（棉花萎林酸负异构体）口服制剂II期临床研究：在肾上腺皮质癌患者中的初步疗效和安全性研究
Hao Xie,Jun Yin,Manisha H Shah et al.
Hao Xie et al.
Background Adrenal cortical carcinoma (ACC) is a rare cancer with treatment options of limited efficacy, and poor prognosis if metastatic. AT-101 is a more potent inhibitor of B cell lymphoma 2 family apoptosis-related proteins than its rac...
Sequential therapy with sorafenib and regorafenib for advanced hepatocellular carcinoma: a multicenter retrospective study in Japan [0.03%]
索拉非尼与雷戈拉法尼序贯疗法治疗晚期肝细胞癌的多中心回顾性研究
Sadahisa Ogasawara,Yoshihiko Ooka,Norio Itokawa et al.
Sadahisa Ogasawara et al.
Background Conversion from sorafenib to regorafenib is primarily an evidence-based treatment strategy in patients with advanced hepatocellular carcinoma (HCC). This study aimed to assess the safety and efficacy of sequential therapy with so...
Multicenter Study
Investigational new drugs. 2020 Feb;38(1):172-180. DOI:10.1007/s10637-019-00801-8 2020
Effects of chemotherapy on placental development and function using in vitro culture of human primary cytotrophoblasts [0.03%]
化疗对胎盘发育和功能的影响：人主要合胞体滋养细胞的体内培养研究
Christophe Louis Depoix,Arthur Colson,Mina Mhallem-Gziri et al.
Christophe Louis Depoix et al.
Introduction Cancers during pregnancy can be treated with chemotherapy after the first trimester but the treatment is associated with smaller placentas and an increased risk of stillbirth, fetal growth retardation and preterm delivery. We d...
Pharmacological effects of the simultaneous and sequential combinations of trifluridine/tipiracil (TAS-102) and 5-fluorouracil in fluoropyrimidine-sensitive colon cancer cells [0.03%]
三氟尿苷/チピラシル(TAS-102)与5-氟尿嘧啶联用对氟尿嘧啶敏感的结肠癌细胞的药理学作用
Paola Orlandi,Daniela Gentile,Marta Banchi et al.
Paola Orlandi et al.
The aim of this study was to investigate possible synergistic effects in vitro of trifluridine/tipiracil (TAS-102) and 5-fluoruracil (5-FU) on fluoropyrimidine-sensitive colon cancer cell lines of different mutational status in order to bui...
Phase II study of avelumab in multiple relapsed/refractory germ cell cancer [0.03%]
一项评价在复发/难治性继发性生殖细胞癌患者中使用阿维鲁单抗疗效的Ⅱ期研究
M Mego,D Svetlovska,M Chovanec et al.
M Mego et al.
Background Germ cell tumors (GCTs) are highly curable diseases; however, not all patients can be cured. Patients in their second relapse have especially poor prognoses. PD-L1 expression is significantly higher in GCTs than in normal testicu...
Apoptosis induction and cell cycle arrest of pladienolide B in erythroleukemia cell lines [0.03%]
巴瑞克替尼治疗红白血病细胞系凋亡诱导及周期停滞作用研究
Joana Jorge,Sara Petronilho,Raquel Alves et al.
Joana Jorge et al.
Splicing of pre-mRNA into functional mRNA, carried out by the spliceosome, represents a crucial step in eukaryotic gene expression. Mutations and other deregulation in some of the spliceosome components have been identified in multiple path...
Entrectinib resistance mechanisms in ROS1-rearranged non-small cell lung cancer [0.03%]
ROS1重排非小细胞肺癌患者恩曲替尼耐药机制分析
Bo Mi Ku,Yeon Hee Bae,Kyoung Young Lee et al.
Bo Mi Ku et al.
Entrectinib is a pan-tyrosine-kinase inhibitor that targets oncogenic rearrangements in NTRK, ROS1 and ALK. The combined results of two clinical trials demonstrated the efficacy of entrectinib in ROS1-rearranged NSCLC. Because the developme...
Phase I study of the indoleamine 2,3-dioxygenase 1 inhibitor navoximod (GDC-0919) as monotherapy and in combination with the PD-L1 inhibitor atezolizumab in Japanese patients with advanced solid tumours [0.03%]
单药及联合PD-L1抑制剂阿特朱单抗在晚期实体瘤日本患者中的I期研究：IDO1抑制剂navoximod（GDC-0919）
Takahiro Ebata,Toshio Shimizu,Yutaka Fujiwara et al.
Takahiro Ebata et al.
Navoximod (GDC-0919) is a small molecule inhibitor of indoleamine-2,3-dioxygenase 1. This study investigated the safety, tolerability and pharmacokinetics of navoximod alone and in combination with atezolizumab in Japanese patients with adv...
Reduced expression of annexin A1 promotes gemcitabine and 5-fluorouracil drug resistance of human pancreatic cancer [0.03%]
Annexin A1表达沉默通过促进胰腺癌细胞的自噬逃逸而导致吉西他滨和氟尿嘧啶耐药性获得
Qing-Hua Liu,Hong-Mei Yong,Qing-Xin Zhuang et al.
Qing-Hua Liu et al.
Intrinsic chemoresistance is the main reason for the failure of human pancreatic ductal adenocarcinoma (PDAC) therapy. To identify the candidate protein, we compared the protein expression profiling of PDAC cells and its distinct surviving ...
Assessment of the cytotoxic effects of aporphine prototypes on head and neck cancer cells [0.03%]
阿普ophine原型对头颈癌细胞细胞毒效应的评价
Dorival Mendes Rodrigues-Junior,Nicolie Melanie de Almeida Pontes,Gabriela Estrela de Albuquerque et al.
Dorival Mendes Rodrigues-Junior et al.
Purpose Among alkaloids, abundant secondary metabolites in plants, aporphines constitute a class of compounds with interesting biological activities, including anticancer effects. The present study evaluated the anticancer activities of 14 ...