Xanthan gum-based hydrogel containing nanocapsules for cutaneous diphenyl diselenide delivery in melanoma therapy [0.03%]
含硒纳米胶囊的黄原胶基水凝胶在黑色素瘤治疗中用于皮肤递送二苯并硒烯的方法
Luana Mota Ferreira,Marcel Henrique Marcondes Sari,Juliana Hofstatter Azambuja et al.
Luana Mota Ferreira et al.
The aim of this study was to further evaluate the antitumoral effect of (PhSe)2-loaded polymeric nanocapsules (NC (PhSe)2) against a resistant melanoma cell line (SK-Mel-103) and develop a xanthan gum-based hydrogel intending the NC (PhSe)2...
Retrospective comparison of nab-paclitaxel plus ramucirumab and paclitaxel plus ramucirumab as second-line treatment for advanced gastric cancer focusing on peritoneal metastasis [0.03%]
纳米白蛋白结合型紫杉醇联合瑞戈非尼与多西他赛联合瑞戈非尼二线治疗晚期胃癌的回顾性分析:focus于腹膜转移患者
Masashi Ishikawa,Satoru Iwasa,Kengo Nagashima et al.
Masashi Ishikawa et al.
Background Ramucirumab (RAM) plus solvent-based (sb)-paclitaxel (PTX) is the standard second-line chemotherapy for advanced gastric cancer (AGC). The subset analysis of the ABSOLUTE trial, which confirmed non-inferiority of weekly nanoparti...
In vivo and in vitro inhibition of osteosarcoma growth by the pan Bcl-2 inhibitor AT-101 [0.03%]
AT-101通过抑制Bcl-2家族多种蛋白而对骨肉瘤的体内和体外生长具有抑制作用
Laura Masuelli,Monica Benvenuto,Valerio Izzi et al.
Laura Masuelli et al.
Osteosarcoma (OS) is the most common primary malignant bone tumor and mainly affects children and adolescents. The OS five-year survival rate remains very low. Thus, novel therapeutic protocols for the treatment of OS are needed. Several ap...
Targeting ROS overgeneration by N-benzyl-2-nitro-1-imidazole-acetamide as a potential therapeutic reposition approach for cancer therapy [0.03%]
N-苯基-2-硝基-1-咪唑乙酰胺靶向ROS过产生作为癌症治疗的药物再定位潜在治疗策略
Rodrigo C Zeferino,Nádia S R S Mota,Valdelúcia M A S Grinevicius et al.
Rodrigo C Zeferino et al.
BackgroundWe investigated the role of reactive oxygen species (ROS) in the anticancer mechanism of N-benzyl-2-nitro-1-imidazole-acetamide (BZN), a drug used in Chagas' disease treatment. MethodsBALB/c mice, inoculated with Ehrlich ascites c...
Vitamin K3 thio-derivative: a novel specific apoptotic inducer in the doxorubicin-sensitive and -resistant cancer cells [0.03%]
维生素K3硫衍生物：诱导多柔比星敏感和耐药癌细胞凋亡的新物质
Mohamed-Elamir F Hegazy,Masashi Fukaya,Mona Dawood et al.
Mohamed-Elamir F Hegazy et al.
Vitamin K3, also known as menadione, is a synthetic lipid-soluble 2-methyl-1,4- naphthoquinone analogs of vitamin K. The vitamin K derivatives exhibit potent cytotoxicity against several cancer cell lines through ROS induction and mitochond...
Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects-results from the POUDER pilot study [0.03%]
尽管 broccoli sprout 补充剂对胰腺癌晚期患者有积极作用，但患者很难坚持服用——POUDER 研究初步结果
Vladimir J Lozanovski,Georgios Polychronidis,Wolfgang Gross et al.
Vladimir J Lozanovski et al.
Pancreatic ductal adenocarcinoma is a highly aggressive malignancy with short survival and limited therapeutic options. Broccoli sulforaphane is a promising new treatment due to the results of recent epidemiological, experimental and patien...
Evaluation of absorption, distribution, metabolism, and excretion of [14C]-rucaparib, a poly(ADP-ribose) polymerase inhibitor, in patients with advanced solid tumors [0.03%]
评估聚腺苷二磷酸核糖聚合酶抑制剂鲁卡帕尼（rucaparib）在晚期实体瘤患者中的吸收、分布、代谢和排泄
Mingxiang Liao,Simon Watkins,Eileen Nash et al.
Mingxiang Liao et al.
Rucaparib, a poly(ADP-ribose) polymerase inhibitor, is licensed for use in recurrent ovarian, fallopian tube, or primary peritoneal cancer. We characterized the absorption, distribution, metabolism, and elimination of rucaparib in 6 patient...
Tetra-substituted pyrrole derivatives act as potent activators of p53 in melanoma cells [0.03%]
四取代吡咯衍生物可有效激活黑色素瘤细胞中的p53蛋白
Maria Chiara Proto,Donatella Fiore,Giovanni Forte et al.
Maria Chiara Proto et al.
Cutaneous melanoma, the most aggressive form of skin cancer, is characterized by activating BRAF mutations. Despite the initial success of selective BRAF inhibitors, only few patients exhibited complete responses, whereas many showed diseas...
A randomized phase 2 trial of the efficacy and safety of a novel topical povidone-iodine formulation for Cancer therapy-associated Paronychia [0.03%]
用于癌症治疗引起的甲沟炎的新颖 topical 瑞代安碘配方的 II 期随机对照试验
Kara D Capriotti,Milan Anadkat,Jennifer Choi et al.
Kara D Capriotti et al.
Purpose Cancer therapy-associated paronychia (CAP) is a frequent adverse event associated with cytotoxic and targeted therapies that may impact dosing of anticancer therapies and patient quality of life (QoL). There are currently no evidenc...
Anticancer activity of a novel methylated analogue of L-mimosine against an in vitro model of human malignant melanoma [0.03%]
L-芒柄花碱甲基化类似物抗肿瘤活性的研究及其对人类黑色素瘤的体外模型作用研究
Sotiris Kyriakou,Melina Mitsiogianni,Theodora Mantso et al.
Sotiris Kyriakou et al.
The anticancer activity of a series of novel synthesized, hydroxypyridone-based metal chelators (analogues of L-mimosine) was evaluated in an in vitro model of melanoma consisting of malignant melanoma (A375), non-melanoma epidermoid carcin...