Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer [0.03%]
用于晚期癌症患者的14C-胍地西明的质量平衡和代谢物特征分析
Jeroen Roosendaal,Hilde Rosing,Luc Lucas et al.
Jeroen Roosendaal et al.
Purpose The objective of this mass balance trial was to determine the excretory pathways and metabolic profile of the novel anticancer agent guadecitabine in humans after administration of a 14C-radiolabeled dose of guadecitabine. Experimen...
Synthesis and cellular effects of novel 1,3,5-triazine derivatives in DLD and Ht-29 human colon cancer cell lines [0.03%]
新型三嗪衍生物的合成及其对DLD和Ht-29人结肠癌细胞系的生物学活性
Agnieszka Wróbel,Beata Kolesińska,Justyna Frączyk et al.
Agnieszka Wróbel et al.
This study provides new information on the cellular effects of 1,3,5-triazine nitrogen mustards with different peptide groups in DLD and Ht-29 human colon cancer cell lines. A novel series of 2,4,6-trisubstituted 1,3,5-triazine derivatives ...
A phase Ib study of a PI3Kinase inhibitor BKM120 in combination with panitumumab in patients with KRAS wild-type advanced colorectal cancer [0.03%]
一项Ⅰb期临床研究：BKM120与帕尼单抗联合治疗KRAS野生型晚期结直肠癌患者的研究
Rachel Goodwin,Derek Jonker,Eric Chen et al.
Rachel Goodwin et al.
Background Resistance to Epidermal Growth Factor inhibition (EGFRi) in patients with KRAS wild-type (wt) Colorectal Cancer (CRC) may occur as a result of PI3K/AKT/mTOR signaling. We conducted a study to establish the recommended phase II do...
A new series of acetohydroxamates shows in vitro and in vivo anticancer activity against melanoma [0.03%]
一类乙酰羟胺酸衍生物通过体内外实验显示对黑色素瘤有抑制作用
Gabriela C Segat,Camila G Moreira,Evelyn C Santos et al.
Gabriela C Segat et al.
Cancer treatment is challenging, mainly due to high levels of drug toxicity and the resistance of tumours to chemotherapy. Hydroxamic acid derivatives have recently aroused attention due to their potential to treat malignancies. In the pres...
Osimertinib in a patient with non-small cell lung cancer and renal failure undergoing hemodialysis: a case report [0.03%]
阿美替尼治疗肾功能不全接受血液透析的非小细胞肺癌患者：一例报告
Atsushi Matsunashi,Daichi Fujimoto,Kazutaka Hosoya et al.
Atsushi Matsunashi et al.
Osimertinib is a key drug for cancer patients with EGFR mutations. However, there is little information about its safety in cancer patients who require hemodialysis (HD) for chronic renal failure, despite notable increases in their numbers....
Radiosensitizing effects of trabectedin on human A549 lung cancer cells and HT-29 colon cancer cells [0.03%]
曲贝替丁诱导肺癌A549和结肠癌HT-29细胞放射增敏作用
Katrin Manda,Tina Präkelt,Tonja Schröder et al.
Katrin Manda et al.
Background and Purpose Trabectedin is a unique alkylating agent with promising effects against a range of solid tumors. In this study, we aimed to examine the cytotoxic and radiosensitizing effects of trabectedin on two human epithelial tum...
A Phase 1 study of BAL101553, a novel tumor checkpoint controller targeting microtubules, administered as 48-h infusion in adult patients with advanced solid tumors [0.03%]
BAL101553（一种新型肿瘤检查点调节剂，可靶向微管）在晚期实体瘤成人患者中持续48小时输注的I期研究
Markus Joerger,Anastasios Stathis,Yannis Metaxas et al.
Markus Joerger et al.
Purpose BAL101553, the prodrug of the microtubule-destabilizer BAL27862, previously showed signs of antitumor activity when administered as a 2-h infusion, but its use was limited by vascular toxicity. We investigated an alternative dosing ...
The tumor suppressor NDRG2 cooperates with an mTORC1 inhibitor to suppress the Warburg effect in renal cell carcinoma [0.03%]
肿瘤抑制因子NDRG2与mTORC1抑制剂合作抑制肾细胞癌的瓦尔堡效应
Xi&#x;an Li,Guangdong Hou,Zheng Zhu et al.
Xi&#x;an Li et al.
Renal cell carcinoma (RCC) is one of the most common malignancies worldwide, and metabolic reprogramming has a profound effect on RCC tumorigenesis. mTORC1 inhibitors are widely used in RCC treatment, yet some types of RCC cells are resista...
Effects of salinomycin and niclosamide on small cell lung cancer and small cell lung cancer circulating tumor cell lines [0.03%]
盐霉素和氯硝柳胺对小细胞肺癌及小细胞肺癌循环肿瘤细胞系的影响
Maximilian Hochmair,Barbara Rath,Lukas Klameth et al.
Maximilian Hochmair et al.
Tumor dissemination and recurrence is attributed to highly resistant cancer stem cells (CSCs) which may constitute a fraction of circulating tumor cells (CTCs). Small cell lung cancer (SCLC) constitutes a suitable model to investigate the r...
A phase I study of enfortumab vedotin in Japanese patients with locally advanced or metastatic urothelial carcinoma [0.03%]
Enfortumab vedotin治疗局部晚期或转移性尿路上皮癌的I期研究在日本患者中的结果
Shunji Takahashi,Motohide Uemura,Tomokazu Kimura et al.
Shunji Takahashi et al.
Locally advanced or metastatic urothelial cancer is an aggressive form of cancer with high recurrence rates and low survival. Nectin-4 is a cell adhesion molecule commonly expressed in several tumors, including high expression in urothelial...