Sorafenib may enhance antitumour efficacy in hepatocellular carcinoma patients by modulating the proportions and functions of natural killer cells [0.03%]
索拉非尼通过调节自然杀伤细胞的比例和功能增强对肝癌患者的抗肿瘤疗效
Jie Hu,Enxin Wang,Lei Liu et al.
Jie Hu et al.
Dysfunction of natural killer (NK) cells is associated with poor prognosis in hepatocellular carcinoma (HCC). We explored the phenotypic and functional characteristics of peripheral blood NK cells in HCC patients following sorafenib treatme...
Controlled Clinical Trial
Investigational new drugs. 2020 Oct;38(5):1247-1256. DOI:10.1007/s10637-019-00885-2 2020
[HuArgI (co)-PEG5000]-induced arginine deprivation leads to autophagy dependent cell death in pancreatic cancer cells [0.03%]
[HuArgI (co)-PEG5000]诱导的精氨酸剥夺导致胰腺癌细胞依赖自噬的细胞死亡
Nathalie Khalil,Ralph J Abi-Habib
Nathalie Khalil
In this study, we examined the sensitivity of pancreatic cancer cells to [HuArgI (Co)-PEG5000]-induced arginine deprivation as well as the mechanisms underlying deprivation-induced cell death. [HuArgI (Co)-PEG5000]-induced arginine deprivat...
Risk factors for cancer-associated thrombosis in patients undergoing treatment with immune checkpoint inhibitors [0.03%]
免疫检查点抑制剂治疗患者的癌症相关血栓的风险因素
Yosuke Ando,Takahiro Hayashi,Reiko Sugimoto et al.
Yosuke Ando et al.
Purpose Anticancer agents are known to increase cancer-associated thrombosis (CAT) onset. CAT onset rate is reported to be 1.92% in cisplatin-based therapy, 6.1% in paclitaxel plus ramucirumab combination therapy, and 11.9% in bevacizumab m...
W941, a new PI3K inhibitor, exhibits preferable anti-proliferative activities against nonsmall cell lung cancer with autophagy inhibitors [0.03%]
PI3K抑制剂W941联合自噬抑制剂对非小细胞肺癌的增殖抑制作用
Dong Liang,Hong-Ying Wang,Shu Fan et al.
Dong Liang et al.
The PI3K pathway is aberrantly activated in many cancers and plays a critical role in tumour cell proliferation and survival, making it a rational therapeutic target. In the present study, the effects and the underlying mechanism of a new P...
Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma [0.03%]
少突胶质细胞瘤继发替莫唑胺耐药后mRNA、lncRNA及circRNA的表达谱与生物信息学分析
Chengbin Zhao,Yuyuan Gao,Ruiming Guo et al.
Chengbin Zhao et al.
Temozolomide is a first line anti-tumor drug used for the treatment of patients with Glioblastoma multiforme (GBM). However, the drug resistance to temozolomide limits its clinical application. Therefore, novel strategies to overcome chemor...
Phase I study of TAS-115, a novel oral multi-kinase inhibitor, in patients with advanced solid tumors [0.03%]
TAS-115治疗难治性晚期实体瘤的I期临床研究
Toshihiko Doi,Nobuaki Matsubara,Akira Kawai et al.
Toshihiko Doi et al.
TAS-115 is a novel MET, VEGFR, FMS and PDGFR inhibitor, developed to improve the continuity of drug administration with a relatively short half-life. We assessed its tolerability, safety, pharmacokinetics, efficacy, and pharmacodynamics in ...
Combination of a novel microtubule inhibitor MBRI-001 and gemcitabine synergistically induces cell apoptosis by increasing DNA damage in pancreatic cancer cell lines [0.03%]
新型微管抑制剂MBRI-001联合吉西他滨通过增加DNA损伤在胰腺癌细胞系中协同诱导细胞凋亡
Yuqian Liu,Ruochen Zang,Feifei Li et al.
Yuqian Liu et al.
Pancreatic cancer (PC) is a highly malignant cancer with poor prognosis. Although gemcitabine (GEM; 2',2'-difluoro-deoxycytidine) has been used as the first-line chemotherapeutic agent in PC treatment for decades, its limited efficacy remai...
Association between metastatic sites and first-line pembrolizumab treatment outcome for advanced non-small cell lung cancer with high PD-L1 expression: a retrospective multicenter cohort study [0.03%]
高PD-L1表达晚期非小细胞肺癌患者一线帕博利珠单抗治疗与远处转移灶之间的关系：一项基于多中心队列的回顾性研究
Hayato Kawachi,Motohiro Tamiya,Akihiro Tamiya et al.
Hayato Kawachi et al.
Associations between treatment outcomes of immune checkpoint inhibitors and metastatic sites in advanced non-small cell lung cancer (NSCLC) are not well known. Therefore, this multicenter retrospective study aimed to investigate the predict...
Matteucinol, isolated from Miconia chamissois, induces apoptosis in human glioblastoma lines via the intrinsic pathway and inhibits angiogenesis and tumor growth in vivo [0.03%]
马兜铃叶中分离得到的马兜铃内酯醇可通过内在凋亡途径诱导人胶质母细胞瘤细胞凋亡，并且体内实验证明其可抑制血管生成和肿瘤生长
Ana Gabriela Silva,Viviane Aline O Silva,Renato J S Oliveira et al.
Ana Gabriela Silva et al.
Gliomas account for nearly 70% of the central nervous system tumors and present a median survival of approximately 12-17 months. Studies have shown that administration of novel natural antineoplastic agents is been highly effective for trea...
Factors affecting symptom presentation in an early-phase clinical trials clinic patient population [0.03%]
影响一期临床试验受试者人群症状表现的因素
Goldy C George,Tito R Mendoza,Eucharia C Iwuanyanwu et al.
Goldy C George et al.
Increasing numbers of oncology therapies are being approved based on early-phase single-arm studies. Yet, little is known regarding the use of patient-reported outcomes in single-arm oncology trials testing novel therapies. We examined pati...