Crizotinib induced antitumor activity and synergized with chemotherapy and hormonal drugs in breast cancer cells via downregulating MET and estrogen receptor levels [0.03%]
克里唑蒂尼通过降低MET和雌激素受体水平诱导乳腺癌细胞的抗肿瘤活性并协同化疗和荷尔蒙药物治疗
Nehad M Ayoub,Dalia R Ibrahim,Amer E Alkhalifa et al.
Nehad M Ayoub et al.
MET is a receptor tyrosine kinase known to drive neoplastic transformation and aggressive tumor phenotypes. Crizotinib is an oral multi-targeted tyrosine kinase inhibitor of MET, ALK, RON, and ROS1 kinases. In this study, the anticancer eff...
Erlotinib and bevacizumab in elderly patients ≥75 years old with non-small cell lung cancer harboring epidermal growth factor receptor mutations [0.03%]
厄洛替尼和贝伐单抗在≥75岁伴有表皮生长因子受体突变的非小细胞肺癌老年患者中的应用
Yoichiro Aoshima,Masato Karayama,Naoki Inui et al.
Yoichiro Aoshima et al.
The efficacy and safety of combination therapy with erlotinib and bevacizumab in elderly patients with non-small-cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) gene mutations are unknown. Elderly patients aged ≥...
Phase I/II study of erlotinib plus S-1 for patients with previously treated non-small cell lung cancer: Thoracic Oncology Research Group (TORG) 0808/0913 [0.03%]
厄洛替尼联合S-1治疗既往经治的非小细胞肺癌的I/II期研究：胸部肿瘤研究组(TORG) 0808/0913
Yoshiro Nakahara,Tsuneo Shimokawa,Yuki Misumi et al.
Yoshiro Nakahara et al.
Introduction In preclinical data, the combination therapy with S-1 and epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) had a synergistic antitumor effect on non-small cell lung cancer (NSCLC), regardless of the EGFR ...
Development of a carrier system containing hyaluronic acid and protamine for siRNA delivery in the treatment of melanoma [0.03%]
含有透明质酸和鱼精蛋白用于恶性黑色素瘤的siRNA传递载体系统的开发
Jing Yang,Rong Zhao,Qun Feng et al.
Jing Yang et al.
The use of small interfering RNA (siRNA) in melanoma treatment remains limited owing to its biological properties. Herein, we developed a carrier system containing hyaluronic acid and protamine for siRNA delivery. Considering zeta potential...
Atezolizumab plus carboplatin and etoposide in small cell lung cancer patients previously treated with platinum-based chemotherapy [0.03%]
阿特珠单抗联合卡铂和依托泊苷治疗先前接受过基于铂类化疗的小细胞肺癌患者
Hidenobu Ishii,Koichi Azuma,Akihiko Kawahara et al.
Hidenobu Ishii et al.
Although immune checkpoint inhibitors have improved the survival of small cell lung cancer (SCLC) patients, their efficacy in SCLC patients who relapsed after systemic chemotherapy is unclear. This retrospective study aimed to investigate t...
Dual-function chimeric antigen receptor T cells targeting c-Met and PD-1 exhibit potent anti-tumor efficacy in solid tumors [0.03%]
针对c-Met和PD-1的双功能嵌合抗原受体T细胞在实体瘤中表现出强大的抗肿瘤疗效
Xingxing Yuan,Zujun Sun,Qingyun Yuan et al.
Xingxing Yuan et al.
Purpose Programmed cell death 1 (PD-1), which is upregulated under the continuous induction of the tumor microenvironment, causes chimeric antigen receptor (CAR)-T cell hypofunction via interaction with programmed death ligand 1 (PD-L1). Th...
Analysis and identification of novel biomarkers involved in neuroblastoma via integrated bioinformatics [0.03%]
通过综合生物信息学分析和识别涉及神经母细胞瘤的新生物标志物
Bo Chen,Peng Ding,Zhongyan Hua et al.
Bo Chen et al.
Neuroblastoma (NB) is the most common extracranial solid tumor in children. Under various treatments, some patients still have a poor prognosis. Hence, it is necessary to find new valid targets for NB therapy. In this study, a comprehensive...
A phase I study of intraperitoneal paclitaxel combined with gemcitabine plus nab-paclitaxel for pancreatic cancer with peritoneal metastasis [0.03%]
用于治疗腹膜转移性胰腺癌的静脉注射紫杉醇联合吉西他滨加奈 Paclitaxel临床一期研究
Naminatsu Takahara,Yousuke Nakai,Hironori Ishigami et al.
Naminatsu Takahara et al.
Purpose: A phase I study of intraperitoneal paclitaxel (ip PTX) combined with gemcitabine (GEM) plus nab-paclitaxel (nab-PTX) (GnP) was conducted to determine the maximum tolerated dose (MTD) and the recommended dose (RD)...
B7-H6 as an efficient target for T cell-induced cytotoxicity in haematologic malignant cells [0.03%]
B7-H6是血液恶性肿瘤细胞中T细胞诱导的细胞毒性的有效靶点
Xin Sun,Jingyuan Zhao,Li Ma et al.
Xin Sun et al.
T cells play crucial roles in the antitumour immune response. However, their dysfunction leads to inefficient tumour eradication. New members of the B7 family have moved to the fore of cancer research because of their involvement in T cell-...
Glioma progression is suppressed by Naringenin and APO2L combination therapy via the activation of apoptosis in vitro and in vivo [0.03%]
柚皮素和APO2L联合疗法通过激活凋亡抑制胶质瘤的进展（体内外）
Tao Song,Mingyu Zhang,Jun Wu et al.
Tao Song et al.
Naringenin (NG) is a natural antioxidant flavonoid which is isolated from citrus fruits, and has been reported to inhibit colon cancer proliferation. However, the effects of NG treatment on glioma remain to be elucidated. The present study ...