The novel low molecular weight MYC antagonist MYCMI-6 inhibits proliferation and induces apoptosis in breast cancer cells [0.03%]
新型低分子量MYC拮抗剂MYCMI-6抑制乳腺癌细胞的增殖并诱导其凋亡
Dalal AlSultan,Emma Kavanagh,Shane O&#x;Grady et al.
Dalal AlSultan et al.
Background The MYC oncogene is one of the most frequently altered driver genes in cancer. MYC is thus a potential target for cancer treatment as well as a biomarker for the disease. However, as a target for treatment, MYC has traditionally ...
A phase Ib study of the highly selective MET-TKI savolitinib plus gefitinib in patients with EGFR-mutated, MET-amplified advanced non-small-cell lung cancer [0.03%]
高选择性MET-TKI赛沃替尼联合吉非替尼治疗EGFR突变，MET扩增的晚期非小细胞肺癌的Ib期研究
Jin-Ji Yang,Jian Fang,Yong-Qian Shu et al.
Jin-Ji Yang et al.
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are recommended first-line treatments in EGFR-mutated (EGFRm) non-small-cell lung cancer (NSCLC). However, acquired resistance (e.g. MET amplification) is frequently ob...
Glochidiol, a natural triterpenoid, exerts its anti-cancer effects by targeting the colchicine binding site of tubulin [0.03%]
天然三萜化合物Glochidiol通过靶向微管秋水仙碱结合位点产生抗癌作用
Hongjie Chen,Lijun Miao,Fengxiang Huang et al.
Hongjie Chen et al.
Glochidiol has been shown to have potentially antiproliferative activity in vitro, however its anticancer mechanisms specifically against lung cancer remain unknown. This study aimed to investigate the anti-lung cancer effects of glochidiol...
Determinants of pain in advanced HCC patients recieving hepatic artery infusion chemotherapy [0.03%]
接受肝动脉灌注化疗的晚期HCC患者的疼痛决定因素
Zhiqiang Wu,Wenbo Guo,Song Chen et al.
Zhiqiang Wu et al.
Purpose Hepatic arterial infusion chemotherapy (HAIC) is one of the options to treat unresectable hepatocellular carcinoma (HCC). The majority of HCC patients suffer great pain in the course of HAIC treatment. To improve the quality of life...
Discovery of oxyepiberberine as a novel tubulin polymerization inhibitor and an anti-colon cancer agent against LS-1034 cells [0.03%]
氧表小檗碱作为微管聚合抑制剂和抗结肠癌物质在LS-1034细胞中的发现
Hanbing Ning,Wenquan Lu,Qiaoyu Jia et al.
Hanbing Ning et al.
Coptis chinensis Franch. has been extensively used in traditional Chinese medicine. The chemical structure of oxyepiberberine, as an alkaloid isolated from Coptis chinensis Franch., has been previously studied. However, anti-cancer effects ...
rAj-Tspin, a novel recombinant peptide from Apostichopus japonicus, suppresses the proliferation, migration, and invasion of BEL-7402 cells via a mechanism associated with the ITGB1-FAK-AKT pathway [0.03%]
来自日本海参的新型重组肽rAj-Tspin通过ITGB1-FAK-AKT通路机制抑制BEL-7402细胞的增殖，迁移和侵袭
Ping Yu,Rui Wu,Zunchun Zhou et al.
Ping Yu et al.
Purpose Our study aimed to investigate the antitumor effects of rAj-Tspin on BEL-7402 hepatocellular carcinoma cells and to explore the underlying mechanism. Method For the in vivo experiment, BEL-7402 cells were inoculated subcutaneously i...
A phase II study of Mirvetuximab Soravtansine in triple-negative breast cancer [0.03%]
Mirvetuximab Soravtansine在三阴性乳腺癌中的II期研究
Clinton Yam,Gaiane M Rauch,Tanbin Rahman et al.
Clinton Yam et al.
Folate receptor alpha (FRα) has been reported to be expressed in up to 80% of triple-negative breast cancers (TNBC) with limited expression in normal tissues, making it a promising therapeutic target. Mirvetuximab soravtansine (mirvetuxima...
The bromodomain and extra-terminal domain inhibitor JQ1 synergistically sensitizes human colorectal cancer cells to topoisomerase I inhibitors through repression of Mre11-mediated DNA repair pathway [0.03%]
溴结构域和额外终端域抑制剂JQ1通过抑制Mre11介导的DNA修复途径协同增强人类结肠癌细胞对拓扑异构酶I抑制剂的敏感性
Linping Lei,Xuqin Xie,Long He et al.
Linping Lei et al.
Camptothecin (CPT) and its derivatives, irinotecan and topotecan are specific topoisomerase I (Top1) inhibitors and potent anticancer drugs. Mechanistically, they induce DNA double-strand breaks (DSBs). Although CPT is an effective chemothe...
Esomeprazole inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis [0.03%]
埃索美拉唑通过抑制溶酶体半胱氨酸蛋白酶莱格明来防止癌症转移
Tian Zhao,Yujie Liu,Yanfei Hao et al.
Tian Zhao et al.
Legumain is a newly discovered lysosomal cysteine protease that can cleave asparagine bonds and plays crucial roles in regulating immunity and cancer metastasis. Legumain has been shown to be highly expressed in various solid tumors, within...
Identification and characterization of deschloro-chlorothricin obtained from a large natural product library targeting aurora A kinase in multiple myeloma [0.03%]
来自大型天然产物库的deschloro-chlorothricin在多发性骨髓瘤中对aurora A激酶的作用识别与特征分析
Nadire Özenver,Sara Abdelfatah,Anette Klinger et al.
Nadire Özenver et al.
Multiple myeloma (MM) is a devastating disease with low survival rates worldwide. The mean lifetime of patients may be extendable with new drug alternatives. Aurora A kinase (AURKA) is crucial in oncogenesis, because its overexpression or a...