Potent synergistic anti-tumor activity of a novel humanized anti-HER2 antibody hersintuzumab in combination with trastuzumab in xenograft models [0.03%]
一种新型人源化抗HER2单克隆抗体hersintuzumab联合曲妥珠单抗在移植瘤模型中的协同抗肿瘤活性研究
Fariba Shiravi,Mehdi Mohammadi,Forough Golsaz-Shirazi et al.
Fariba Shiravi et al.
Immunotherapy of HER2-overexpressing cancers by FDA approved monoclonal antibodies (mAbs) such as trastuzumab and pertuzumab has shown promising results. We have recently produced a novel humanized anti-HER2 mAb, hersintuzumab, which did no...
BIX-01294, a G9a inhibitor, suppresses cell proliferation by inhibiting autophagic flux in nasopharyngeal carcinoma cells [0.03%]
BIX-01294(G9a抑制剂)通过抑制自噬流阻抑鼻咽癌细胞增殖
Qian Li,Liuqian Wang,Di Ji et al.
Qian Li et al.
G9a, a histone methyltransferase, has been found to be upregulated in a range of tumor tissues, and contributes to tumor growth and metastasis. However, the impact of G9a inhibition as a potential therapeutic target in nasopharyngeal carcin...
Drug repurposing using transcriptome sequencing and virtual drug screening in a patient with glioblastoma [0.03%]
利用转录组测序和虚拟药物筛选对胶质母细胞瘤患者的药物再定位研究
Mohamed E M Saeed,Onat Kadioglu,Henry Johannes Greten et al.
Mohamed E M Saeed et al.
Background Precision medicine and drug repurposing are attractive strategies, especially for tumors with worse prognosis. Glioblastoma is a highly malignant brain tumor with limited treatment options and short survival times. We identified ...
Simvastatin treatment varies the radiation response of human breast cells in 2D or 3D culture [0.03%]
辛伐他汀治疗改变了人类乳腺细胞二维或三维培养中的放射反应
Katrin Manda,Dajana Juerß,Paul Fischer et al.
Katrin Manda et al.
Background Statins inhibit the cholesterol biosynthesis and are used as cholesterol-lowering agents in fat-metabolism disorders. Furthermore, several studies state that statins have supportive functions in breast cancer treatment. Therefore...
Drug-repositioning screening identified fludarabine and risedronic acid as potential therapeutic compounds for malignant pleural mesothelioma [0.03%]
药物再定位筛选鉴定氟达拉滨和利塞膦酸作为恶性胸膜间皮瘤的潜在治疗化合物
Irene Dell&#x;Anno,Sarah A Martin,Marcella Barbarino et al.
Irene Dell&#x;Anno et al.
Objectives Malignant pleural mesothelioma (MPM) is an occupational disease mainly due to asbestos exposure. Effective therapies for MPM are lacking, making this tumour type a fatal disease. Materials and Methods In order to meet this need a...
Signal transducer and activator of transcription 3 inhibition alleviates resistance to BRAF inhibition in anaplastic thyroid cancer [0.03%]
信号转导和转录激活因子3抑制可缓解桥本甲状腺炎癌对BRAF抑制的耐药性
Ying Wang,Zhigang Hu,Weiyuan Ma et al.
Ying Wang et al.
Anaplastic thyroid cancer (ATC) is a rare type of thyroid cancer (TC) with no effective therapeutic strategy. Although surgery, chemotherapy and radiation are all available for ATC treatment, the median survival for ATC patients is less tha...
4Ei-10 interdiction of oncogenic cap-mediated translation as therapy for non-small cell lung cancer [0.03%]
抑制致癌帽介导翻译治疗非小细胞肺癌的新药4Ei-10研究
Blake A Jacobson,Zeeshan Ahmad,Sierra Chen et al.
Blake A Jacobson et al.
In order to suppress 5' cap-mediated translation a highly available inhibitor of the interaction between the 5' mRNA cap and the eIF4E complex has been developed. 4Ei-10 is a member of the class of ProTide compounds and has elevated membran...
Generation of fully human anti-GPC3 antibodies with high-affinity recognition of GPC3 positive tumors [0.03%]
全人源GPC3抗体的生成及其对GPC3阳性肿瘤的高度亲和力识别作用研究
Lin Yu,Xi Yang,Nan Huang et al.
Lin Yu et al.
The acceleration of therapeutic antibody development has been motivated by the benefit to and their demand for human health. In particular, humanized transgenic antibody discovery platforms, combined with immunization, hybridoma fusion and/...
Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells [0.03%]
阿博灵通过抑制LSD1发挥抗胃癌上皮间质转化作用
Yafei Chu,Zheng Xiao,Nan Jing et al.
Yafei Chu et al.
Arborinine is a natural product isolated from G. parva leaf extracts, which displays potentially antiproliferative activity against human cervical cancer cells. In contrast, its anticancer effects against gastric cancer cells and drug-resis...
María Belen Cancela,Santiago Zugbi,Ursula Winter et al.
María Belen Cancela et al.
Intraocular retinoblastoma treatment has changed radically over the last decade, leading to a notable improvement in ocular survival. However, eyes that relapse remain difficult to treat, as few alternative active drugs are available. More ...