First-in-human, phase I/IIa study of CRLX301, a nanoparticle drug conjugate containing docetaxel, in patients with advanced or metastatic solid malignancies [0.03%]
CRLX301（包含多西他赛的纳米颗粒药物结合物）治疗晚期或转移性实体瘤患者Ⅰ/Ⅱa期临床试验
Sarina A Piha-Paul,Kyaw Z Thein,Paul De Souza et al.
Sarina A Piha-Paul et al.
Background This was a phase I/IIa study to investigate the tolerability, efficacy and pharmacokinetics (PK)/ pharmacodynamics (PD) of CRLX301, CDP-based nanoparticle formulation of docetaxel. Methods The study was conducted in two parts. In...
Effects of glutamine for prevention of radiation-induced esophagitis: a double-blind placebo-controlled trial [0.03%]
谷氨酰胺预防放射性食管炎的疗效研究：一项双盲安慰剂对照临床试验
Anas Alshawa,Alexandra Perez Cadena,Bettzy Stephen et al.
Anas Alshawa et al.
Purpose Acute radiation-induced esophagitis (ARIE) leads to treatment delays, decreased quality of life (QOL), and secondary adverse events such as weight loss. Grade 3 ARIE occurs in 15%-30% of patients undergoing radiotherapy to the esoph...
Dissociated response and clinical benefit in patients treated with nivolumab monotherapy [0.03%]
纳武单抗单药治疗患者的分离反应及临床获益关系分析
Yuki Sato,Takeshi Morimoto,Shigeo Hara et al.
Yuki Sato et al.
Immune checkpoint inhibitors (ICIs) are effective for previously treated patients with advanced non-small cell lung cancer (NSCLC). However, an unconventional response pattern is sometimes encountered. A dissociated response (DR), character...
Histone deacetylase inhibitor chidamide regulates the Wnt/β-catenin pathway by MYCN/DKK3 in B-ALL [0.03%]
组蛋白去乙酰化酶抑制剂希美纳通过MYCN/DKK3调节Wnt/β-catenin信号通路在B系急性淋巴细胞白血病中的作用机制研究
Linlin Zhao,Chengfang Lv,Lili Sun et al.
Linlin Zhao et al.
Our previous studies revealed that MYCN downregulates the expression of DKK3, activates the Wnt/β-catenin signalling pathway at the transcriptional level, and thereby promotes the development of B cell acute lymphocytic leukaemia (B-ALL) b...
A first-in-human, phase 1 study of the NEDD8 activating enzyme E1 inhibitor TAS4464 in patients with advanced solid tumors [0.03%]
TAS4464在晚期实体瘤患者中I期首次人体研究
Noboru Yamamoto,Toshio Shimizu,Kan Yonemori et al.
Noboru Yamamoto et al.
Background This open-label, phase 1 study investigated TAS4464, a potent NEDD8-activating enzyme inhibitor, in patients with advanced/metastatic solid tumors (JapicCTI-173,488; registered 13/01/2017). The primary objective was dose-limiting...
Pharmaceutical good manufacturing practice: Leuplin® production in Japan identifies major international shortcomings [0.03%]
日本有关Leuplin®生产的药品生产质量管理规范指出国际主要不足之处
Masahiro Wada,Akihiko Ozaki,Takashi Miyachi et al.
Masahiro Wada et al.
In Japan, the production of Leuplin®, a key drug for the treatment of prostate cancer and breast cancer, was temporarily suspended in 2020 by the manufacturer. The incident illustrated several significant failings, namely the lack of unifo...
Association of XRCC3 rs1799794 polymorphism with survival of glioblastoma multiforme patients treated with combined radio-chemotherapy [0.03%]
胶质母细胞瘤多形体患者联合放化疗疗效与XRCC3基因rs1799794多态性的关联分析
Francesco Pasqualetti,Alessandra Gonnelli,Paola Orlandi et al.
Francesco Pasqualetti et al.
This study reports the results of a monocentric prospective analysis conducted with the aim of evaluating the impact of XRCC1 rs25487, XRCC3 rs861539, XRCC3 rs1799794, RAD51 rs1801320 and GSTP-1 rs1695 single nucleotide polymorphisms (SNP) ...
Phase 2 study of bevacizumab plus carboplatin/nab-paclitaxel followed by bevacizumab plus nab-paclitaxel for non-squamous non-small cell lung cancer with malignant pleural effusion [0.03%]
贝伐珠单抗联合卡铂/白蛋白结合型紫杉醇一线治疗伴有恶性胸腔积液的非鳞状非小细胞肺癌后序贯贝伐珠单抗联合白蛋白结合型紫杉醇疗效和安全性的II期研究
Motohiro Tamiya,Akihiro Tamiya,Hidekazu Suzuki et al.
Motohiro Tamiya et al.
Objectives Vascular endothelial growth factor plays an important role in the pathogenesis of malignant pleural effusion (MPE). We previously showed the efficacy of bevacizumab (Bev) plus carboplatin (CBDCA)/paclitaxel (PTX) in the treatment...
Autophagy promotes oncolysis of an adenovirus expressing apoptin in human bladder cancer models [0.03%]
自噬促进表达凋亡素的腺病毒在人类膀胱癌模型中的溶瘤效应
Chao Shang,Yi-Long Zhu,Yi-Quan Li et al.
Chao Shang et al.
As a potential cancer therapy, we developed a recombinant adenovirus named Ad-VT, which was designed to express the apoptosis-inducing gene (apoptin) and selectively replicate in cancer cells via E1a manipulation. However, how it performs i...
A phase Ib, open-label, dose-escalation trial of the anti-CD37 monoclonal antibody, BI 836826, in combination with gemcitabine and oxaliplatin in patients with relapsed/refractory diffuse large B-cell lymphoma [0.03%]
BI 836826（一种抗CD37单克隆抗体）联合吉西他滨和奥沙利铂治疗复发/难治性弥漫大B细胞淋巴瘤Ib期、开放标签、剂量递增试验
Monica Balzarotti,Massimo Magagnoli,Miguel Ángel Canales et al.
Monica Balzarotti et al.
Background BI 836826 is a chimeric mouse-human monoclonal antibody directed against human CD37, a transmembrane protein expressed on mature B lymphocytes. This open-label, phase I dose-escalation trial (NCT02624492) was conducted to determi...