Lars Bohlin,Ulf Göransson,Cecilia Alsmark et al.
Lars Bohlin et al.
With a realistic threat against biodiversity in rain forests and in the sea, a sustainable use of natural products is becoming more and more important. Basic research directed against different organisms in Nature could reveal unexpected in...
Rüdiger Kaspera,Rodney Croteau
Rüdiger Kaspera
Cytochrome P450 monooxygenases play a prominent role in the biosynthesis of the diterpenoid anticancer drug Taxol, as they appear to constitute about half of the 19 enzymatic steps of the pathway in yew (Taxus) species. A combination of cla...
Rodney Croteau,Raymond E B Ketchum,Robert M Long et al.
Rodney Croteau et al.
Biosynthesis of the anticancer drug Taxol in Taxus (yew) species involves 19 steps from the universal diterpenoid progenitor geranylgeranyl diphosphate derived by the plastidial methyl erythritol phosphate pathway for isoprenoid precursor s...
Dale G Nagle,Yu-Dong Zhou
Dale G Nagle
Marine natural products have become a major source of new chemical entities in the discovery of potential anticancer agents that potently suppress various antitumor molecular targets. As a consequence of insufficient vascularization, hypoxi...