Fabrication and evaluation of quinine-loaded chitosan-polycaprolactone core-shell polymeric nanoparticles for the treatment of malaria: an in vitro and in silico study [0.03%]
用于治疗疟疾的氯喹-壳聚糖-聚己内酯载药核心-壳聚糖聚合物纳米颗粒的制备及评价：体外和计算机模拟研究
Yohana Amos,Edwar D Montenegro,Clarence Rubaka et al.
Yohana Amos et al.
Malaria remains a major global health challenge, worsened by the rise of drug-resistant Plasmodium falciparum. Quinine is a cornerstone therapy for severe malaria, yet its clinical use is limited by rapid clearance, dose-dependent toxicity,...
Advances in biopolymer-based floating raft drug delivery systems for gastroretentive therapy [0.03%]
基于生物聚合物的漂浮筏药物递送系统在胃滞留治疗中的进展
Adarsha Bachhar,Shila Barman,Arindam Sarkar et al.
Adarsha Bachhar et al.
The efficient gastric absorption of orally administered drugs showing pH-dependent solubility, narrow absorption windows, or localized gastric action remains a critical challenge. Conventional immediate-release and sustained-release dosage ...
Arya Tripathi,Molakpogu Ravindra Babu,Sarad Pawar Naik Bukke et al.
Arya Tripathi et al.
Dissolving microneedles (DMNs) have attracted significant interest due to their superior physicochemical properties, including enhanced skin penetration, improved bioavailability, and reduced toxicity compared to conventional drug delivery ...
Electrically active biomaterials for osteochondral tissue engineering: a review [0.03%]
用于骨软骨组织工程的导电生物材料：综述
Şeymanur Berat Yeni,Azime Erarslan,Esma Ahlatcıoğlu Özerol
Şeymanur Berat Yeni
Osteochondral tissues have limited self-healing capacity due to its avascular nature, making injuries and degenerative diseases particularly difficult to treat with conventional methods. Osteochondral tissue engineering has emerged as a pro...
Design and fabrication of a biocompatible nanocomposite patch for mechanical reinforcement and stress concentration reduction in cracked bone tissue [0.03%]
一种用于增强受损骨组织力学性能和降低应力集中的生物相容性纳米复合材料补丁的设计与制备
Hoda Hoseini,Sara Daneshjou,Aboulfazl Mirzapoor et al.
Hoda Hoseini et al.
This study experimentally investigates the use of a biocompatible nanocomposite patch reinforced with carbon nanotubes (CNTs) to mechanically strengthen cracked bone tissue by mitigating stress concentration. Reducing stress intensity facto...
Targeted lipid-polymer hybrid nanocapsules for controlled codelivery of doxorubicin and paclitaxel: physicochemical characterization and In vitro anticancer evaluation [0.03%]
用于药物联合控释的紫杉醇和阿霉素共载脂质聚合物混合纳米囊泡：物理化学性质表征及体外抗癌活性评价
Ehsan Nankali,Doga Kavaz,Masoud Shaabanzadeh et al.
Ehsan Nankali et al.
The enhancement of efficacy via the optimization of cancer drug ratios in lipid-polymer hybrid nanocapsules (LPHNs), including doxorubicin (DOX) and paclitaxel (PTX), at diverse ratios, represents a viable approach for optimizing cancer the...
An overview of commercially available polymers for colon-targeted drug delivery systems [0.03%]
用于结肠给药系统商用聚合物的综述
Debaprasad Ghosh,Reshma Sharma,Deepti Katiyar et al.
Debaprasad Ghosh et al.
The colon consists of the cecum, transverse colon, ascending colon, descending colon, and sigmoid colon. Colonic diseases such as inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colon cancer, and various other conditions m...
Nanoscale coordination polymers: synthesis, characterization, and emerging biomedical applications [0.03%]
纳米尺度配位聚合物的合成、表征及新兴生物医学应用
Anindya De,Atanu Kotal
Anindya De
Nanoscale coordination polymers (NCPs) encompassing both crystalline nanoscale metal-organic frameworks (nanoMOFs) and amorphous coordination polymer nanoparticles have emerged as adaptable hybrid materials. They have adjustable composition...
Targeted cancer therapy using single- and multi-drug loaded nanoformulations: a comprehensive review [0.03%]
用于癌症治疗的单药和多药纳米载体综合述评
Ayse Nur Nurdogan,Ayse Karatug Kacar
Ayse Nur Nurdogan
Cancer therapy continues to face significant limitations related to insufficient selectivity, systemic toxicity, and therapeutic resistance, driving growing interest in nanoformulation-based targeted approaches. This review critically synth...
Development and evaluation of a chitosan-coated alginate microsphere system for Thymus vulgaris and Calendula officinalis oil delivery [0.03%]
一种用于递送薄荷油和翠菊油的壳聚糖包覆海藻酸盐微球系统的开发与评价研究
Elif Hatice Gürkan,Cengizhan Çakır
Elif Hatice Gürkan
This study aimed to develop and characterize chitosan-coated alginate microspheres for the encapsulation and controlled delivery of Thymus vulgaris and Calendula officinalis oils, selected for their well-documented antimicrobial, anti-infla...