Does oxidatively damaged DNA drive amyloid-β generation in Alzheimer's disease? A hypothesis [0.03%]
氧化应激损伤的DNA是否驱动了阿尔茨海默病中淀粉样蛋白-β的产生？一种新的假说
Owen Davis Sanders,Lekshmy Rajagopal,Jayalekshmi Archa Rajagopal
Owen Davis Sanders
In Alzheimer's disease (AD), amyloid-β (Aβ) generation and upstream β-secretase 1 (BACE1) expression appear to be driven by oxidative stress via c-Jun N-terminal kinase (JNK), p38, and Interferon-Induced, Double-Stranded RNA-Activated Pr...
Atulya Iyengar,Chun-Fang Wu
Atulya Iyengar
Hypersynchronous neural activity is a characteristic feature of seizures. Although many Drosophila mutants of epilepsy-related genes display clear behavioral spasms and motor unit hyperexcitability, field potential measurements of aberrant ...
Environmental influences on for-mediated oviposition decisions in Drosophila melanogaster [0.03%]
环境因素对果蝇Drosophila melanogaster产卵决策的影响
Anders Vesterberg,Rudy Rizkalla,Mark J Fitzpatrick
Anders Vesterberg
Deciding whether or not to lay an egg on a given substrate is an important task undertaken by females of many arthropods. It involves perceiving the environment (e.g. quality of the substrate, temperature, and humidity), formulating a decis...
H Sofia Pereira,Karen D Williams,J Steven de Belle
H Sofia Pereira
A comprehensive science, technology, engineering, and mathematics (STEM) education has persistent formative effects on individuals, communities, and society. In this regard, Marla Sokolowski's academic legacy will forever reflect her unique...
Molecular spectrum, family screening and genetic counselling of Spinocerebellar Ataxia (SCA) cases in an Indian scenario [0.03%]
印度脊髓小脑性共济失调病例的分子谱系、家族筛查和基因咨询
Priyanka Vishwakarma,Sarita Agarwal,Deepika Delsa Dean et al.
Priyanka Vishwakarma et al.
Spinocerebellar Ataxia (SCA) is a heterogeneous adult-onset disorder with an autosomal dominant inheritance pattern mainly caused by triplet repeat expansions. Clinical diagnosis of SCA is based on phenotypic features followed by confirmati...
Travels with Curly: A personal, collegial tribute to Professor Marla Sokolowski [0.03%]
与Curly一起旅行：献给马拉·索科洛夫斯基教授的个人同事纪念文集
W Thomas Boyce
W Thomas Boyce
Marla Sokolowski's work and humanity has influenced the careers of hundreds, perhaps thousands, of younger scientists. Her fundamental research on the neurogenetic underpinnings of behavior in Drosophila melanogaster is remarkable not only ...
Gaining an understanding of behavioral genetics through studies of foraging in Drosophila and learning in C. elegans [0.03%]
通过果蝇觅食和线虫学习实验了解行为遗传学
Aaron P Reiss,Catharine H Rankin
Aaron P Reiss
The pursuit of understanding behavior has led to investigations of how genes, the environment, and the nervous system all work together to produce and influence behavior, giving rise to a field of research known as behavioral neurogenetics....
Harold L Atwood
Harold L Atwood
Marla Sokolowski's scientific achievements established her as an internationally recognized leader in behavioural genetics. As a graduate student, she made a significant discovery while observing natural populations of the fruit fly, Drosop...
Allen B Sokolowski
Allen B Sokolowski
The foraging gene as a modulator of division of labour in social insects [0.03%]
取食基因在社会性昆虫劳动分工中的作用机制研究
Christophe Lucas,Yehuda Ben-Shahar
Christophe Lucas
The social ants, bees, wasps, and termites include some of the most ecologically-successful groups of animal species. Their dominance in most terrestrial environments is attributed to their social lifestyle, which enable their colonies to e...