LncRNA GAS5 promotes epilepsy progression through the epigenetic repression of miR-219, in turn affecting CaMKIIγ/NMDAR pathway [0.03%]
长链非编码RNA GAS5通过表观遗传抑制miR-219促进癫痫进展并进而影响CaMKIIγ/NMDAR通路
Chen-Sheng Zhao,Dong-Xing Liu,Yan-Huai Fan et al.
Chen-Sheng Zhao et al.
It has been widely reported that dysregulated long-chain noncoding RNAs (lncRNAs) are closely associated with epilepsy. This study aimed to probe the function of lncRNA growth arrest-specific 5 (GAS5), microRNA (miR)-219 and Calmodulin-depe...
Novel insights into the genetic profile of hereditary spastic paraplegia in India [0.03%]
印度遗传性痉挛性截瘫的基因型新见解
Sundarapandian Narendiran,Monojit Debnath,Sumanth Shivaram et al.
Sundarapandian Narendiran et al.
The Hereditary Spastic Paraplegias (HSPs) are a group of clinically and genetically heterogeneous disorders characterized by length dependent degeneration of the corticospinal tracts. Genetic data related to HSPs are limited from India. We ...
Reduction of the α-synuclein expression promotes slowing down early neuropathology development in the Drosophila model of Parkinson's disease [0.03%]
α-突触核蛋白表达降低能减缓帕金森病果蝇模型中早期神经病理学进展
Ilia M Golomidov,Evgenia M Latypova,Elena V Ryabova et al.
Ilia M Golomidov et al.
Parkinson's disease (PD) is a neurodegenerative disease characterised by the formation of Lewy bodies and progressive loss of dopaminergic (DA) neurons in the substantia nigra. Lewy bodies mainly consist of α-synuclein, which plays a criti...
lncRNA XIST induces Aβ accumulation and neuroinflammation by the epigenetic repression of NEP in Alzheimer's disease [0.03%]
长链非编码RNA XIST通过表观遗传学抑制NEP诱导阿尔茨海默病中Aβ沉积和神经炎症作用机制研究
Xi-Wu Yan,Huai-Jun Liu,Yu-Xing Hong et al.
Xi-Wu Yan et al.
Alzheimer's disease (AD) is the leading cause of dementia globally, but effective treatment is lacking. We aimed to explore lncRNA XIST role in AD and the mechanisms involved in the effect of changes in lncRNA XIST on the expression of Aβ-...
Spatiotemporal organization of enteroendocrine peptide expression in Drosophila [0.03%]
果蝇肠内分泌肽表达的时空组织结构
Sooin Jang,Ji Chen,Jaekyun Choi et al.
Sooin Jang et al.
The digestion of food and absorption of nutrients occurs in the gut. The nutritional value of food and its nutrients is detected by enteroendocrine cells, and peptide hormones produced by the enteroendocrine cells are thought to be involved...
Forty years of foraging research: a legacy of scientists trained and influenced by Marla Sokolowski [0.03%]
四十年的研究觅食：Marla Sokolowski训练和影响的科学家留下的遗产
Ina Anreiter,Jeffrey S Dason
Ina Anreiter
Jeffrey S Dason,Ina Anreiter,Chun-Fang Wu
Jeffrey S Dason
Aaron M Allen,Marla B Sokolowski
Aaron M Allen
The foraging gene in Drosophila melanogaster, which encodes a cGMP-dependent protein kinase, is a highly conserved, complex gene with multiple pleiotropic behavioral and physiological functions in both the larval and adult fly. Adult foragi...
Generation and characterization of fruitless P1 promoter mutant in Drosophila melanogaster [0.03%]
果蝇fruitlessP1启动子突变体的构建及鉴定
Megan C Neville,Alexander Eastwood,Aaron M Allen et al.
Megan C Neville et al.
The identification of mutations in the gene fruitless (fru) paved the way for understanding the genetic basis of male sexual behavior in the vinegar fly Drosophila melanogaster. D. melanogaster males perform an elaborate courtship display t...
Characterization of a novel stimulus-induced glial calcium wave in Drosophila larval peripheral segmental nerves and its role in PKG-modulated thermoprotection [0.03%]
新型刺激诱导的果蝇幼虫外周节段神经胶质钙波及其在PKG调节的热保护中的作用特征分析
Jennifer L Krill,Ken Dawson-Scully
Jennifer L Krill
Insects, as poikilotherms, have adaptations to deal with wide ranges in temperature fluctuation. Allelic variations in the foraging gene that encodes a cGMP dependent protein kinase, were discovered to have effects on behavior in Drosophila...