Inter-organ regulation by the brain in Drosophila development and physiology [0.03%]
果蝇发育和生理中的脑对其他器官的调控作用
Sunggyu Yoon,Mingyu Shin,Jiwon Shim
Sunggyu Yoon
The brain plays an essential role in regulating physiological homeostasis by communicating with other organs. Neuronal cells either directly innervate target tissues and transmit signals or secrete systemic factors into the hemolymph to reg...
Ashok R Dinasarapu,Diane J Sutcliffe,Fatemeh Seifar et al.
Ashok R Dinasarapu et al.
Lesch-Nyhan disease (LND) is a neurodevelopmental disorder caused by variants in the HPRT1 gene, which encodes the enzyme hypoxanthine-guanine phosphoribosyl transferase (HGprt). HGprt deficiency provokes numerous metabolic changes which va...
The light-activated TRP channel: the founding member of the TRP channel superfamily [0.03%]
光激活的TRP通道：_TRP_通道超家族的创始成员
Baruch Minke,William L Pak
Baruch Minke
The Drosophila light-activated Transient Receptor Potential (TRP) channel is the founding member of a large and diverse family of channel proteins. The Drosophila TRP (dTRP) channel, which generates the electrical response to light has been...
Greg S B Suh,Kweon Yu,Young-Joon Kim et al.
Greg S B Suh et al.
Neurogenetic research using the Drosophila model has immensely expanded around the world. Likewise, scientists in South Korea have leveraged the advantages of Drosophila genetic tools to understand various neurobiological processes. In this...
PTK2 regulates tau-induced neurotoxicity via phosphorylation of p62 at Ser403 [0.03%]
PTK2通过在Ser403位点磷酸化p62调节tau诱导的神经毒性
Shinrye Lee,Myungjin Jo,Younghwi Kwon et al.
Shinrye Lee et al.
Tau is a microtubule-associated protein that forms insoluble filaments that accumulate as neurofibrillary tangles in neurodegenerative diseases such as Alzheimer's disease and other related tauopathies. A relationship between abnormal Tau a...
TERT distal promoter GC islands are critical for telomerase and together with DNMT3B silencing may serve as a senescence-inducing agent in gliomas [0.03%]
端粒酶后半部分GC岛区域对于端粒酶的活性至关重要，而其与DNMT3B沉默可能在胶质瘤诱导衰老中起到作用
Naz Şerifoğlu,Begün Erbaba,Michelle M Adams et al.
Naz Şerifoğlu et al.
Telomerase is reactivated in the majority of cancers. For instance, in gliomas, it is common that the TERT promoter is mutated. Research on telomere promoter GC islands have been focused primarily on proximal TERT promoter but little is kno...
Knockdown of PHLDA2 promotes apoptosis and autophagy of glioma cells through the AKT/mTOR pathway [0.03%]
PHLDA2基因沉默通过AKT/mTOR信号转导途径促进胶质瘤细胞凋亡及自噬
Chengyong Guo,Shuo Liu,Tao Zhang et al.
Chengyong Guo et al.
Pleckstrin homology like domain family A member 2 (PHLDA2) is an imprinted gene expressed in placenta and has been shown to be associated with tumor progression. However, the effect of PHLDA2 on glioma cell growth has not been reported yet....
The force-from-lipid principle and its origin, a ' what is true for E. coli is true for the elephant' refrain [0.03%]
“来自动物膜的力原则及其起源，‘大肠杆菌所呈现的事实对于大象同样适用’”
Boris Martinac,Ching Kung
Boris Martinac
The force-from-lipid (FFL) principle states that it is the lateral stretch force from the lipid membrane that ultimately opens mechanosensitive (MS) channels, not the external tether nor the internal cytoskeleton. Piezo channels for certain...
Abnormal larval neuromuscular junction morphology and physiology in Drosophila prickle isoform mutants with known axonal transport defects and adult seizure behavior [0.03%]
果蝇轴浆运输缺陷和成年期惊厥行为的prickle异构体突变体中异常的幼虫神经肌肉突触形态和生理学特征
Atsushi Ueda,Tristan C D G O&#x;Harrow,Xiaomin Xing et al.
Atsushi Ueda et al.
Previous studies have demonstrated the striking mutational effects of the Drosophila planar cell polarity gene prickle (pk) on larval motor axon microtubule-mediated vesicular transport and on adult epileptic behavior associated with neuron...