Starvation-induced sleep suppression requires the Drosophila brain nutrient sensor [0.03%]
饥饿诱导的睡眠抑制需要果蝇大脑中的营养传感器
Yangkyun Oh,Greg S B Suh
Yangkyun Oh
Animals increase their locomotion activity and reduce sleep duration under starved conditions. This suggests that sleep and metabolic status are closely interconnected. The nutrient and hunger sensors in the Drosophila brain, including diur...
A deep learning analysis of Drosophila body kinematics during magnetically tethered flight [0.03%]
一种深度学习分析方法：果蝇磁性束缚飞行过程中身体运动学分析
Geonil Kim,JoonHu An,Subin Ha et al.
Geonil Kim et al.
Flying Drosophila rely on their vision to detect visual objects and adjust their flight course. Despite their robust fixation on a dark, vertical bar, our understanding of the underlying visuomotor neural circuits remains limited, in part d...
Knockdown of circ_CLIP2 regulates the proliferation, metastasis and apoptosis of glioma cells through miR-641/EPHA3/STAT3 axis [0.03%]
circ_CLIP2通过miR-641/EPHA3/STAT3轴调节胶质瘤细胞的增殖、转移和凋亡敲低研究
Huibing Li,Xin Jin,Mingyao Lai et al.
Huibing Li et al.
A great amount of reaches have confirmed that circular RNAs (circRNAs) are novel regulators in glioma progression. Here, our work aimed to probe the specific role of circ_CLIP2 in glioma. The mRNA and protein expressions were analyzed by qR...
A conserved function of Pkhd1l1, a mammalian hair cell stereociliary coat protein, in regulating hearing in zebrafish [0.03%]
PKHD1L1是哺乳动物毛细胞立体纤毛被膜蛋白，其在斑马鱼中调节听觉的保守功能
Stylianos Makrogkikas,Ruey-Kuang Cheng,Hao Lu et al.
Stylianos Makrogkikas et al.
Pkhd1l1 is predicted to encode a very large type-I transmembrane protein, but its function has largely remained obscure. Recently, it was shown that Pkhdl1l1 is a component of the coat that decorates stereocilia of outer hair cells in the m...
Evaluation of mouse behavioral responses to nutritive versus nonnutritive sugar using a deep learning-based 3D real-time pose estimation system [0.03%]
基于深度学习的三维实时姿态估计系统评估小鼠对营养糖与非营养糖的行为反应
Jineun Kim,Dae-Gun Kim,Wongyo Jung et al.
Jineun Kim et al.
Animals are able to detect the nutritional content of sugar independently of taste. When given a choice between nutritive sugar and nonnutritive sugar, animals develop a preference for nutritive sugar over nonnutritive sugar during a period...
An expansion of phenotype: novel homozygous variant in the MED17 identified in patients with progressive microcephaly and global developmental delay [0.03%]
表型的扩展：在进行性小头畸形和整体发育延迟的患者中鉴定出MED17基因的新纯合变异
Rafiullah Rafiullah,Alia M Albalawi,Sultan R Alaradi et al.
Rafiullah Rafiullah et al.
Global developmental delay (GDD) is a lifelong disability that affects 1-3% of the population around the globe. It is phenotypically variable and highly heterogeneous in terms of the underlying genetics. Patients with GDD are intellectually...
Hoyeon Lee,Chunghun Lim
Hoyeon Lee
Circadian rhythms and sleep homeostasis constitute the two-process model for daily sleep regulation. However, evidence for circadian control of sleep-wake cycles has been relatively short since clock-less animals often show sleep behaviors ...
Knockdown of glutathione S-transferase leads to mislocalization and accumulation of cabeza, a drosophila homolog of FUS, in the brain [0.03%]
谷胱甘肽S转移酶的敲除会导致果蝇FUS同源物cabeza在脑内定位错误和积聚
Sun Joo Cha,Ja Hoon Yoon,Yeo Jeong Han et al.
Sun Joo Cha et al.
Glutathione S-transferase omega (GSTO) is an antioxidant enzyme involved in reducing oxidative stress. Recent studies suggest that polymorphic variants of GSTOs affect the onset age and progression of neurodegenerative diseases. Although GS...
Possible association between the lrrk2 gene and anxiety behavior: a systematic literature review [0.03%]
lrrk2基因与焦虑行为的相关性研究：系统综述
R E Moreira-Júnior,R M Souza,J G de Carvalho et al.
R E Moreira-Júnior et al.
Alterations to the LRRK2 gene have been associated with Parkinson's disease and alcohol consumption in animals and humans. Furthermore, these disorders are strongly related to anxiety disorders (ADs). Thus, we investigated how the LRRK2 gen...
Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila [0.03%]
降低支链氨基酸转移酶活性可缓解果蝇夜间因光暴露引起的代谢脆弱性
Mari Kim,Gwang-Ic Son,Yun-Ho Cho et al.
Mari Kim et al.
The rhythmic pattern of biological processes controlled by light over 24 h is termed the circadian rhythm. Disturbance of circadian rhythm due to exposure to light at night (LAN) disrupts the sleep-wake cycle and can promote cardiovascular ...