H Moriah Sokolowski
H Moriah Sokolowski
In the first grade, in one of my first classes, my teacher read us a story about a scientist. To my utter shock, the scientist was a man. After the story, I asked the teacher, 'can men be scientists?' She looked at me, bewildered, and repli...
Ralph J Greenspan
Ralph J Greenspan
Marla Sokolowski is a true pioneer in behavioral genetics, having made the first molecular delineation of a naturally occurring behavioral polymorphism in her work on the foraging locus in Drosophila melanogaster. The gene was subsequently ...
Dustin J Sokolowski
Dustin J Sokolowski
I am often asked how our mother inspired my sister Moriah and me to want to become scientists. She never directly suggested we should go down that path. Instead, she shared the aspects of the natural world, that she loved, with us while kee...
Nawar Alwash,Aaron M Allen,Marla B Sokolowski et al.
Nawar Alwash et al.
Drosophila melanogaster displays social behaviors including courtship, mating, aggression, and group foraging. Recent studies employed social network analyses (SNAs) to show that D. melanogaster strains differ in their group behavior, sugge...
A latitudinal cline in a courtship song character of Drosophila melanogaster [0.03%]
果蝇(Drosophila melanogaster)求爱歌曲的纬度性渐变线研究
Rosamund A Stanley,Charalambos P Kyriacou
Rosamund A Stanley
The courtship song of male Drosophila melanogaster is generated by wing vibration and contains an interpulse interval (IPI) which is species-specific and usually falls in the mean range of 30-40 ms. The IPI is extremely temperature-sensitiv...
The foraging gene affects alcohol sensitivity, metabolism and memory in Drosophila [0.03%]
觅食基因影响果蝇的酒精敏感性、代谢和记忆能力
Anne S Oepen,Jamie L Catalano,Reza Azanchi et al.
Anne S Oepen et al.
The genetic basis of alcohol use disorder (AUD) is complex. Understanding how natural genetic variation contributes to alcohol phenotypes can help us identify and understand the genetic basis of AUD. Recently, a single nucleotide polymorphi...
Loss of mGluR1-LTD following cocaine exposure accumulates Ca2+-permeable AMPA receptors and facilitates synaptic potentiation in the prefrontal cortex [0.03%]
暴露于可卡因后mGluR1-LTD丢失，聚集Ca2 +透性AMPA受体，并促进前额叶皮层中的突触增强作用
Hongyu Ruan,Wei-Dong Yao
Hongyu Ruan
Addiction results from drug-elicited alterations of synaptic plasticity mechanisms in dopaminergic reward circuits. Impaired metabotropic glutamate receptor (mGluR)-dependent long-term depression (LTD) and accumulation of synaptic Ca2+-perm...
Dysregulation of Myt1 expression acts as a potential peripheral biomarker for major depressive disorder and bipolar disorder [0.03%]
Myt1表达失调可作为抑郁症和双相情感障碍的外周生物标志物
Maryam Ghanbarirad,Mehrdad Hashemi,Seyed Mehdi Saberi et al.
Maryam Ghanbarirad et al.
Major depressive disorder (MDD) and bipolar disorder (BPD) are among the most debilitating mental conditions. Diagnostic criteria for MDD include psychological and physical symptoms, such as low mood and changes in appetite or sleep, respec...
A cGMP-dependent protein kinase, encoded by the Drosophila foraging gene, regulates neurotransmission through changes in synaptic structure and function [0.03%]
由果蝇foraging基因编码的cGMP依赖蛋白激酶通过改变突触结构和功能调节神经传递
Jeffrey S Dason,Marla B Sokolowski
Jeffrey S Dason
A cGMP-dependent protein kinase (PKG) encoded by the Drosophila foraging (for) gene regulates both synaptic structure (nerve terminal growth) and function (neurotransmission) through independent mechanisms at the Drosophila larval neuromusc...
Analysis of whole genome sequenced cases and controls shows that the association of variants in TOMM40, BCAM, NECTIN2 and APOC1 with late onset Alzheimer's disease is driven by linkage disequilibrium with APOE ε2/ε3/ε4 alleles [0.03%]
全基因组测序的病例和对照分析显示，TOMM40、BCAM、NECTIN2和APOC1变异与晚发性阿尔茨海默病的关系由与APOEε2/ε3/ε4等位基因连锁不平衡驱动
David Curtis;Alzheimer&#x;s Disease Neuroimaging Initiative
David Curtis;Alzheimer&#x;s Disease Neuroimaging Initiative
Variants in APOE are associated with risk of late onset Alzheimer's disease (LOAD) but the magnitude of the effect has been reported to vary across ancestries. Also, other variants in the region have been reported to show association though...