E-cigarette exposure impairs associative memory: role of α7 and β2 nicotinic acetylcholine receptors [0.03%]
电子烟暴露损害联想记忆：α7和β2型烟碱乙酰胆碱受体的作用
Titilayomi Ayomide Otenaike,Oluwabukola Farodoye,Katherina K Silva et al.
Titilayomi Ayomide Otenaike et al.
E-cigarettes also known as vape, are rapidly gaining recognition as having potential neurological consequences, yet their neural effects on sensory valence and associative learning remain poorly understood, necessitating urgent investigatio...
Serum LncRNA XIST and miR-133b as non-invasive biomarkers for diagnosis and progression of Parkinson's disease [0.03%]
血清LncRNA XIST和miR-133b作为诊断和判断帕金森病进展的无创性生物标志物
Weihua Rao,Yanqiong Qin
Weihua Rao
Long non-coding RNA XIST (LncRNA XIST) and microRNA-133b (miR-133b) have been implicated in Parkinson's disease (PD)-related pathophysiology and may serve as potential circulating biomarkers. The aim of this study was to study the serum exp...
A cell-autonomous role for the vitamin B6 metabolism gene PNPO in Drosophila GABAergic neurons [0.03%]
维生素B6代谢基因PNPO在果蝇GABA能神经元中的细胞自主作用
Wenqin Fu,Saul Landaverde,Xiaoxi Zhuang et al.
Wenqin Fu et al.
In animals, the enzyme pyridox(am)ine 5'-phosphate oxidase (PNPO) is critical for synthesizing the active form of vitamin B6 (VB6), pyridoxal 5'-phosphate (PLP), from inactive vitamers. PLP is a required cofactor for many enzymatic reaction...
Conservation and diversification of mating behavior patterns among three sibling species in the Drosophila subobscura species subgroup [0.03%]
三种拟步甲线虫杆菌属ibling物种中交配行为模式的保护和多样化研究
Kenta Tomihara,Ryoya Tanaka,Francisco Rodríguez-Trelles et al.
Kenta Tomihara et al.
Behavioral traits are known to evolve rapidly, often even preceding morphological or physiological changes. However, the genomic and neural bases for such rapid behavioral changes remain to be clarified. Drosophila subobscura is a rare exam...
Genetic convergence in brain aging and neurodegeneration: from cellular mechanisms to therapeutic targets [0.03%]
脑衰老和神经退行性疾病中大脑老化与神經退行性疾病的基因匯聚：从细胞机制到治疗靶点
Picheswara Rao Polu,Shubham Mishra
Picheswara Rao Polu
The distinction between normal brain aging and neurodegeneration has traditionally been viewed as a binary classification, yet emerging evidence reveals a complex continuum of shared genetic mechanisms underlying both processes. This review...
Simultaneous recording of spikes and calcium signals in odor-evoked responses of Drosophila antennal neurons [0.03%]
果蝇触角神经元中气味诱发反应的脉冲和钙信号的同时记录
Yiyi Xiao,Shiuan-Tze Wu,Yinan Xuan et al.
Yiyi Xiao et al.
Most insects, including agricultural pests and disease vectors, rely on olfaction for key innate behaviors. Consequently, there is growing interest in studying insect olfaction to gain insights into odor-driven behavior and to support effor...
Analysis of whole genome sequence data shows association of Alzheimer's disease with rare coding variants in ABCA7, PSEN1, SORL1 and TREM2 [0.03%]
全基因组序列分析显示ABCA7、PSEN1、SORL1和TREM2罕见编码变异与阿尔茨海默病相关
David Curtis,Shujaani Joseph;Alzheimer’s Disease Neuroimaging Initiative
David Curtis
Previous studies have reported associations between risk of Alzheimer's disease (AD) or dementia and rare coding variants in a number of genes. A two-stage strategy was used in which a previously released whole exome sequenced sample was us...
Emma C Spillman,Andrew K Shepherd,Meihua C Kuang et al.
Emma C Spillman et al.
All metazoan guts harbor commensal communities, from a dozen bacterial species in Drosophila to hundreds in humans. Here, we condition flies with diets containing varying levels of protein and sugar to investigate the impact of dietary hist...
The ataxin-2 protein is required in kenyon cells for RNP-granule assembly and appetitive long-term memory formation [0.03%]
Ataxin-2蛋白在肾形细胞中对核糖核蛋白颗粒组装及趋食性长期记忆的形成是必需的
Camilla Roselli,Jens Hillebrand,Jenifer Kaldun et al.
Camilla Roselli et al.
Ribonucleoprotein granules (mRNP granules) are thought to contribute to the control of neuronal mRNA translation required for consolidation of long-term memories. Consistent with this, the function of Ataxin-2 in mRNA granule assembly has b...
Congenital mirror movements in a family: Outcomes associated with DCC mutations [0.03%]
DCC基因突变家族的镜像运动先天症患者的预后
Arife Derda Yücel Şen,Kursat Bora Carman,Çağrı Doğan et al.
Arife Derda Yücel Şen et al.
Introduction: Congenital mirror movement disorder refers to involuntary movements on one side of the body that mimic the deliberate movements on the opposite side. Congenital mirror movement is primarily associated with m...