Fine mapping of a putative genomic element that mediates the induction of a male-specific muscle in Drosophila [0.03%]
果蝇介导诱导雄性特异性肌肉的假定基因组元件的精细映射
Yuri Nakamura,Tamas Lukacsovich,Kenta Tomihara et al.
Yuri Nakamura et al.
The muscle of Lawrence (MOL) is a pair of male-specific longitudinal muscles located below the tergite of the fifth abdominal segment in adult Drosophila melanogaster. For the MOL to form, the innervating motor neuron (MOL-inducing neuron: ...
Albert M Dong,Yi Han,Zheng Xu et al.
Albert M Dong et al.
Psilocybin, a prominent psychedelic, recently emerged as a potential therapeutic agent for psychiatric disorders, yet the molecular and cellular mechanisms driving its effects remain poorly understood. To address these knowledge gaps, we fo...
Novel Variants in PLPBP, SCN1A, and SLC6A1: Genetics, Bioinformatics, and clinical Elucidation of Three Distinct Cases of Developmental and Epileptic Encephalopathy [0.03%]
PLPBP，SCN1A和SLC6A1的新变异：三种发育性和癫痫性脑病的遗传学，生物信息学及临床阐明
Haneieh Honarmand,Sina Babaei,Mortaza Bonyadi et al.
Haneieh Honarmand et al.
Developmental and epileptic encephalopathies (DEEs) are severe early-onset disorders featuring refractory seizures, abnormal EEGs, and developmental delays. Clinically and etiologically heterogeneous, they include subtypes such as Dravet sy...
D-ribose-L-cysteine protects against rotenone-induced neurotoxicity in Drosophila via redox, neurotransmitter, and DDC gene regulation [0.03%]
D-核糖-L-半胱氨酸通过抗氧化、神经递质和DDC基因调控保护罗腾因诱导的果蝇神经毒性
Olumayowa Kolawole Idowu,Adebusola Zainab Sogbesan,Adewale Emmanuel Ajibade et al.
Olumayowa Kolawole Idowu et al.
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by both motor and non-motor dysfunctions. Although the underlying mechanisms are multifactorial, oxidative stress, inflammation, and dopaminergic deficits ar...
Genetic architecture of hereditary spastic paraplegia: from monogenic to oligogenic models [0.03%]
遗传性痉挛性截瘫的遗传结构：从单基因到寡基因模型
Giuseppe Pedullà,Maurizio Morelli,Monica Gagliardi et al.
Giuseppe Pedullà et al.
Hereditary spastic paraplegia (HSP) encompasses a clinically and genetically heterogeneous group of neurodegenerative disorders, characterized by progressive lower limb spasticity due to corticospinal tract degeneration. While traditionally...
Prasidhee Vijayakumar,Kim M Summers,Paul A Dawson
Prasidhee Vijayakumar
Sulfate is a vital nutrient for healthy brain development. More than 90 sulfate-related genes are highly conserved across mammalian species, with 16 of these genes being clinically reportable for adverse brain conditions. To determine the p...
Nckx30c, a Drosophila K+-dependent Na+/Ca2+ exchanger, regulates temperature-sensitive convulsions and age-related neurodegeneration [0.03%]
镍克克斯30C(Nckx30C)是果蝇一种K+依赖的Na+/Ca2+交换器，调节温度敏感性惊厥和年龄相关神经变性
Al Nahian Khan Majlish,Sophia Bourgeois,Shu Hui Lye et al.
Al Nahian Khan Majlish et al.
Calcium (Ca2+) homeostasis is fundamental to neuronal physiology, including in the regulation of membrane excitability and synaptic transmission. Disruptions in the ion transporters regulating Ca2+ influx and efflux are clearly linked to se...
A zinc finger MYM-type containing 3 (ZMYM3) allele is associated with autism spectrum disorder in Iranian people [0.03%]
含有一种与伊朗人自闭症光谱障碍相关的ZMYM3等位基因
Maryam Razavi,Mobina Tabibian,Zahra Lakpour et al.
Maryam Razavi et al.
Previous studies indicate a link between an exceptionally long GA-repeat in the Zinc finger MYM-type containing 3 (ZMYM3) gene and higher-order brain functions, reflected in human-specific cognitive disorders. Here, we studied this GA-repea...
Neurocardiogenetics: Exploring the association of rare RYR2 variants with neuropsychiatric disorders in general and disease populations [0.03%]
神经心律失常的遗传学：罕见RYR2变异体与普通人群和疾病人群的精神神经系统疾病的关联研究
Saif F Dababneh,Jason D Roberts,Sixuan Tan et al.
Saif F Dababneh et al.
Overlapping neuropsychiatric and cardiac features in rare monogenic syndromes stem from shared gene expression. Pathogenic gain-of-function RYR2 variants, leading to a lethal cardiac arrhythmia syndrome known as catecholaminergic polymorphi...
E-cigarette exposure impairs associative memory: role of α7 and β2 nicotinic acetylcholine receptors [0.03%]
电子烟暴露损害联想记忆：α7和β2型烟碱乙酰胆碱受体的作用
Titilayomi Ayomide Otenaike,Oluwabukola Farodoye,Katherina K Silva et al.
Titilayomi Ayomide Otenaike et al.
E-cigarettes also known as vape, are rapidly gaining recognition as having potential neurological consequences, yet their neural effects on sensory valence and associative learning remain poorly understood, necessitating urgent investigatio...