Enhancing the efficiency of achieving optical transparency in live animals using absorbing molecules [0.03%]
利用吸收入体动物提高光学透明度的效率
Ting Sun,Jing Su,Yanjie Zhao et al.
Ting Sun et al.
Significance: In vivo optical imaging is crucial for studying disease mechanisms but is limited by light scattering and poor penetration in biological tissues. While tissue-clearing reagents (hydrophilic/hydrophobic) and ...
Polarizer-assisted pupillometry through closed eyelids, overcoming pupil position dependence [0.03%]
基于偏振光的闭眼瞳孔检测方法及定位不确定下的校正方法研究
Michal Tepper,Omer Ben Barak-Dror,David Haggiag et al.
Michal Tepper et al.
Significance: Accurate monitoring of pupil size and gaze direction is critical in clinical and research contexts; however, current pupillometry methods require open eyes, limiting their use in patients under anesthesia, s...
Corneal dose response from exposure to a Q-switched laser at a central wavelength of 1645 nm using a rabbit model [0.03%]
用于研究皮秒激光作用于家兔角膜损伤阈值的实验模型及结果分析(1645nm)
Joseph J Chue-Sang,Xomalin G Peralta,Joseph E Clary et al.
Joseph J Chue-Sang et al.
Significance: Laser safety studies of the eye are well documented for visible wavelength and continuous wave lasers. There are fewer experimental results for infrared wavelengths and pulsed lasers. ...
Comparing multi- and single-exposure speckle contrast optical spectroscopy methods as estimators of blood flow in the diffuse regime [0.03%]
比较多次曝光和单次曝光散斑对比度光学谱学法在漫散射环境中估计血流的优劣性
Sean Aleman,Arnold D Estrada Jr,Ashwin B Parthasarathy
Sean Aleman
Significance: Speckle contrast optical spectroscopy (SCOS) and speckle plethysmography (SPG) are increasingly used to measure deep tissue blood flow from tissues. However these methods derive flow from measurements at a s...
Comparative Study
Journal of biomedical optics. 2026 Feb;31(2):025002. DOI:10.1117/1.JBO.31.2.025002 2026
Circularly polarized light scattering imaging of a cancerous layer creeping under a healthy layer for the diagnosis of early-stage cervical cancer [0.03%]
圆偏振光散射成像用于诊断早期宫颈癌侵袭层的临床前研究
Nozomi Nishizawa,Mahiro Ishikawa,Mike Raj Maskey et al.
Nozomi Nishizawa et al.
Significance: Cervical cancer progresses through cervical intraepithelial neoplasia (CIN), which are precursor lesions of cervical cancer. In low-grade CIN, atypical cells are generated inside the squamous epithelium, whi...
Integrated spectral and depth compensation approach for optimizing oxygen saturation and total hemoglobin estimation in photoacoustic tomography for ovarian lesion diagnosis [0.03%]
用于卵巢病变诊断的光声断层摄影术中血红蛋白总量和氧饱和度优化估计的集成光谱和深度补偿方法
Lukai Wang,Yixiao Lin,Haolin Nie et al.
Lukai Wang et al.
Significance: Photoacoustic tomography (PAT) holds promise for non-invasive functional imaging in ovarian cancer diagnostics. However, accurate estimation of oxygen saturation ( % sO 2 ) and total hemoglobin concentra...
Deep-learning-based optical coherence tomography reconstruction for high-speed and contrast morphology and vasculature imaging [0.03%]
基于深度学习的光学相干层析重建技术用于高速高对比度形态和血管成像
Yudan Chen,Shuo Chen,Jun Song et al.
Yudan Chen et al.
Significance: Spectral-domain optical coherence tomography (SD-OCT) has been widely used in clinical ophthalmic imaging for high spatial resolution and phase stability. The implementation of multiple spectrometers could h...
Sophie Chagnon-Lessard,Julian Nicolai,Joshua Steller et al.
Sophie Chagnon-Lessard et al.
Significance: Brillouin spectroscopy noninvasively probes mechanical properties of biological materials and has become a valuable tool in various areas of biomedical research. However, the limited contrast of conventional...
Computational modeling of oxygen dynamics in port-wine stain photodynamic therapy: treatment outcome optimization and pain management [0.03%]
用于葡萄酒色斑光动力疗法的氧动力学计算模型：疗效优化和止痛管理
Yijia Li,Qin Li,Xiaoming Hu
Yijia Li
Significance: Port-wine stains (PWSs) are congenital capillary malformations with the incidence of in newborns of ∼ 0.8 % to 2.1%. Hematoporphyrin monomethyl ether-mediated photodynamic therapy (HMME-PDT) has been ...
Polarimetric analysis of the Alzheimer's pathology in excised mouse brain tissue [0.03%]
取下的小鼠脑组织中阿尔茨海默病病理的偏振分析
Gaurav Sharma,Jens Pahnke,Bernhard Roth
Gaurav Sharma
Significance: Given the rapidly ageing global population and the projected rise in dementia cases, research into Alzheimer's disease (AD) has become an urgent scientific and medical priority. Continued investigation into ...