Emerging uses of 5-aminolevulinic-acid-induced protoporphyrin IX in medicine: a review of multifaceted, ubiquitous, molecular diagnostic, therapeutic, and theranostic opportunities [0.03%]
5-氨基乙酰丙酸诱导的原卟啉IX在医学中的新应用：综述多面性、普遍性的分子诊断、治疗和诊疗机会
Brian W Pogue,Bin Chen,Marien I Ochoa et al.
Brian W Pogue et al.
Significance: 5-Aminolevulinic acid (5-ALA) is a medical pro-drug used to induce the intracellular production of protoporphyrin IX (PpIX) via the heme synthesis pathway. Discoveries in mechanisms and developments in novel...
Handheld multispectral photoacoustic imaging for assessing myocardial metabolism [0.03%]
手持式多光谱光声成像技术评估心肌代谢
Bokang Zhai,Yawen Shi,Handi Deng et al.
Bokang Zhai et al.
Significance: Myocardial oxygen metabolism is a key focus of cardiac surgery. It serves as important evidence for surgeons to evaluate surgical quality and surgical plans. However, current clinical methods lack the capabi...
Reverberant optical coherence elastography using 3D-printed randomly distributed scatterers: elasticity mapping of hydrogels in culture dishes [0.03%]
基于3D打印散射器的混响光学相干弹性成像：培养皿中水凝胶弹性图谱映射
Hao Xu,FanLei Yang,Ting Liang et al.
Hao Xu et al.
Significance: Accurate estimation of hydrogel phantom elasticity in 3D cell culture systems provides valuable insights into cellular responses to various mechanical stimuli. Although reverberant wave elastography has been...
Robust lumen segmentation based on temporal residual U-Net using spatiotemporal features in intravascular optical coherence tomography images [0.03%]
基于时空特征的血管内光学相干断层扫描图像时间残差U型网络鲁棒 lumen分割方法
Mingrui He,Yin Yu,Kun Liu et al.
Mingrui He et al.
Significance: Lumen segmentation in intravascular optical coherence tomography (IVOCT) images is essential for quantifying vascular stenosis severity, location, and length. Current methods relying on manual parameter tuni...
Brian W Pogue,Lothar Lilge,Stefan Andersson-Engels et al.
Brian W Pogue et al.
The editorial introduces the special issue honoring Brian C. Wilson as a pioneer of biomedical optics. © 2025 The Authors.
In vivo 3D imaging of ovarian cancer outgrowth in transgenic mouse model with optical coherence tomography [0.03%]
光学相干层析在转基因小鼠卵巢癌三维成像中的应用研究
Huan Han,Aleese Mukhamedjanova,Denise C Connolly et al.
Huan Han et al.
Significance: Peritoneal dissemination is the major mechanism of how ovarian cancer (OC) spreads. It features tumor outgrowths in the form of multicellular spheroids, their detachment from the primary site, and their impl...
Advancements in broadband near-infrared spectroscopy instrumentation for the assessment of in vivo mitochondrial function: a comparative review and outlook [0.03%]
宽频近红外光谱仪在体线粒体功能评估中的应用进展：比较性综述及未来展望
Musa Talati,Ilias Tachtsidis
Musa Talati
Significance: Broadband near-infrared spectroscopy (bNIRS) provides a noninvasive, nonionizing method for measuring oxidative metabolism through monitoring of cytochrome- c -oxidase oxidation changes. Despite its clinica...
Advanced automated classification and segmentation of leukemic cells using simulated optical scanning holography and active contour methods [0.03%]
基于模拟光学扫描全息图和活动轮廓法的白血病细胞自动分类与分割方法研究进展
Abdennacer El-Ouarzadi,Abdelaziz Essadike,Younes Achaoui et al.
Abdennacer El-Ouarzadi et al.
Significance: Leukemia, a complex hematological cancer, poses significant diagnostic challenges due to the heterogeneity of leukemic cells, inter-observer variability, and lack of standardized analysis methodology. Accura...
Quantitative imaging of individual bacterial cells: E. coli and B. subtilis via terahertz scattering-type scanning near-field optical microscopy [0.03%]
单个细菌细胞的定量成像：通过太赫兹散射近场光学显微镜对大肠杆菌和枯草芽孢杆菌进行成像研究
Haneol Lee,Youngil Moon,Donghyun Lee et al.
Haneol Lee et al.
Significance: Terahertz (THz) waves have gained significant attention as an imaging technology due to their ability to provide physical and chemical information in a label-free, noninvasive, and nonionizing manner. Notabl...
3D photogrammetry quantifies the size of basal cell carcinoma lesions with submillimeter accuracy: high correlation with lesion response to photodynamic therapy [0.03%]
三维摄影测量法以亚毫米级精度量化基底细胞癌病变的大小：与光动力疗法诱导的病变反应具有高度相关性
Edward V Maytin,Nathalie C Zeitouni,Abigail Updyke et al.
Edward V Maytin et al.
Significance: Noninvasive imaging to accurately measure subtle changes in tumor size is underutilized when assessing therapeutic responses in the skin. During photodynamic therapy (PDT) for basal cell carcinoma (BCC), a b...