Cholesterol content in the membrane promotes key lipid-protein interactions in a pentameric serotonin-gated ion channel [0.03%]
膜中的胆固醇含量促进五聚体血清素门控离子通道中关键脂质-蛋白质相互作用
Alessandro Crnjar,Carla Molteni
Alessandro Crnjar
Pentameric ligand-gated ion channels (pLGICs), embedded in the lipid membranes of nerve cells, mediate fast synaptic transmission and are major pharmaceutical targets. Because of their complexity and the limited knowledge of their structure...
Improved recovery of cryopreserved cell monolayers with a hyaluronic acid surface treatment [0.03%]
用透明质酸表面处理改善冷冻保存的细胞单层的回收率
Giles T S Kirby,Stuart J Mills,Tanja E Mueller et al.
Giles T S Kirby et al.
Cryopreservation is an essential part of tissue banking and effective cryopreservation methods are critical for the development of cost-effective cell therapy products. Cell sheets are an attractive subset of cell therapy types, and cryopre...
Shelby R Maddox,Xiaoxiao Han,Xiangbo Meng et al.
Shelby R Maddox et al.
There are many different types of surfaces found in nature which can increase or reduce friction, such as the well-studied frog toe or lotus leaf. However, methods for replicating these surfaces on a large scale for use in industrial applic...
Brownian motion-based nanoparticle sizing-A powerful approach for in situ analysis of nanoparticle-protein interactions [0.03%]
基于布朗运动的纳米颗粒尺寸分析——一种用于纳米颗粒-蛋白相互作用原位分析的强大方法
Karin Nienhaus,Gerd Ulrich Nienhaus
Karin Nienhaus
A key hurdle toward effective application of nanoparticles (NPs) in biomedicine is still the incomplete understanding of the biomolecular adsorption layer, the so-called protein corona, which inevitably forms around NPs when they are immers...
Replica molding of cicada wings: The role of water at point of synthesis on nanostructure feature size [0.03%]
蝉翅复制模塑：合成点的水作用对纳米结构特征尺寸的影响
Shauna P Flynn,Stephen Daniels,Brian J Rodriguez et al.
Shauna P Flynn et al.
Many natural surfaces, including the wings of cicada insects, have shown to display bactericidal properties as a result of surface topography. Moreover, the size and distribution of the surface features (on the nano- and microscale) are kno...
Hanne Evenbratt,Marwa Munem,Per Malmberg
Hanne Evenbratt
Precise characterization of a monolayer of two different biomolecules in a gradient pattern on a glass surface puts high demand on the method used. Some techniques can detect protein monolayers but not on a glass surface. Others can disting...
Combatting fungal biofilm formation by diffusive release of fluconazole from heptylamine plasma polymer coating [0.03%]
七胺等离子体聚合涂层氟康唑缓释抗真菌生物膜研究
Javad Naderi,Carla Giles,Solmaz Saboohi et al.
Javad Naderi et al.
A drug-eluting coating applied onto biomedical devices and implants is an appropriate way to ensure that an inhibitory concentration of antimicrobial drugs is present at the device surface, thus preventing surface colonization and subsequen...
Porous silicone substrates inhibit permanent barnacle attachment under natural conditions [0.03%]
多孔硅胶基质在自然条件下可抑制藤壶的附着生长
Dennis S Petersen,Lars Heepe,Stanislav N Gorb
Dennis S Petersen
Barnacles are able to effectively adhere to most surfaces underwater. Dewetting of the corresponding surface prior to the release of their permanent adhesive plays an important role in the attachment process. Possibly, a surface that is abl...
Suman Samantray,David L Cheung
Suman Samantray
It has long been recognized that liquid interfaces, such as the air-water interface (AWI), can enhance the formation of protein fibrils. This makes liquid interfaces attractive templates for fibril formation but fully realizing this require...
Is there a future for additive manufactured titanium bioglass composites in biomedical application? A perspective [0.03%]
有关生物医学应用的增材制造钛生物玻璃复合材料的未来？一种观点
Nour Mani,Antonella Sola,Adrian Trinchi et al.
Nour Mani et al.
Additive manufacturing (AM) of orthopedic implants is growing in popularity as it offers almost complete design flexibility and freedom, meaning complex geometries mimicking specific body parts can be easily produced. Novel composite materi...