Effect of Frequency of Prospekta Administration: Anxiolytic Effect in Wistar Rats [0.03%]
Prospekta给药频率对其抗焦虑作用的影响
Kirill Svitkin,Elizaveta Morozova,Anna Krasheninnikova et al.
Kirill Svitkin et al.
Objectives: The primary objective of this experimental study was to evaluate the severity of the anxiolytic effect of Prospekta, a novel drug for treating cognitive, behavioral, and mental disorders, under different administration regimens....
Assessment of Photo Apoptotic and Genotoxicity of Nalidixic Acid on the Mouse Fibroblast Cell Line Under Ambient Environmental Intensity of UV-B Irradiation [0.03%]
纳洛昔鑫在环境强度UV-B辐射下对小鼠成纤维细胞系的光凋亡和遗传毒性评估研究
Daoud Ali,Bader O Almutairi,Anis Ahmed et al.
Daoud Ali et al.
Objectives: Nalidixic acid has been used as a potent antibiotic drug in the biomedical sciences. In this study, we assessed photochemical properties of nalidixic acid as well as its effect for photocytotoxicity, apoptosis, and genotoxicity ...
Triphasic Dose-Response of Hematological Parameters in Healthcare Workers Exposed to Ionizing Radiations [0.03%]
接受电离辐射的医护人员的血液学参数三相剂量反应关系
Veruscka Leso,Luca Fontana,Daniela Pacella et al.
Veruscka Leso et al.
Objectives: To investigate the impact of chronic and low-dose ionizing radiation (IR) exposure on the workers' hematopoietic system. Methods: Hematological parameters in IR exposed healthcare workers (n. 180) were compared to those determin...
Exosome-Based Liquid Biopsy in Early Screening and Diagnosis of Cancers [0.03%]
基于外泌体的液体活检在癌症早期筛查和诊断中的应用
Xuying Hao,Zihan Liu,Feifei Ma et al.
Xuying Hao et al.
Background: Liquid biopsy, analyzing the expression and variation of circulating tumor cell (CTC) or circulating tumor nucleic acid genes in peripheral blood, can obtain the information of tumorigenesis, metastasis and treatment, which has ...
Jiao Xu,Min Zhang
Jiao Xu
Objectives: To investigate the correlation between Life's Essential 8 (LE8) and frailty in adults with asthma using data from National Health and Nutrition Examination Survey (NHANES). ...
Apigenin Inhibits Cell Ferroptosis by Activating the PI3K/Akt Pathway and Alleviates Renal Injury Caused by Hypertension [0.03%]
染料木素通过激活PI3K/Akt信号通路抑制细胞铁死亡从而缓解高血压肾损伤
Haina Zhang,Yanhua Cao,Liting Jiao et al.
Haina Zhang et al.
Objectives: We aimed to explore the protective role of apigenin (API) and its underlying mechanisms in angiotensin II (Ang II)-induced hypertensive renal injury using both in vivo and in vitro models. Methods: In this study, we developed an...
Comparison of Metoprolol and Sacubitril/Valsartan in Chinese Patients With Heart Failure: A Retrospective Cohort Study [0.03%]
美托洛尔与沙库巴曲缬沙比坦治疗中国心力衰竭患者效果比较：一项回顾性队列研究
Yali Huang,Qianni Lan,Yuan Liu
Yali Huang
Background: Sacubitril/valsartan is recommended for patients with New York Heart Association class II to III heart failure (class 1 recommendation). The objectives of the study were to evaluate the effectiveness and safet...
Mechanism of Protective Effect of Mongolia Medicine Nagab-9 on LPS-Induced Acute Lung Injury Based on an Integrated Network Pharmacology and Experimental Verification [0.03%]
基于网络药理学和实验验证的蒙古药那格巴-9对内毒素致急性肺损伤保护机制的研究
Shi Liu,Jiuwang Yu,Zeyu Chen et al.
Shi Liu et al.
Objectives: To investigate the potential mechanisms of Nagab-9 in alleviating acute lung injury (ALI) by integrating network pharmacology analysis with in vivo and in vitro validation experiments. ...
Metformin Alleviates Fibrosis of Trabecular Meshwork Cells Induced by TGFβ2 Through the Activation of Autophagy [0.03%]
二甲双胍通过激活自噬缓解TGFβ2诱导的小梁网细胞纤维化
Jing Ren,Pengtao Wu,Mengli Liu et al.
Jing Ren et al.
Objective: In this study, we investigated the protective effect of Metformin on fibrosis of trabecular meshwork cells induced by TGFβ2. Methods: ...
Comparative Transcriptomic Analysis Unveils Divergent Effects of FLASH Versus Conventional Irradiation on Skin Cells [0.03%]
比较转录组分析揭示了FLASH与传统电离辐射对皮肤细胞不同影响
Mengmeng Xu,Qiliang Peng,Jun Zhang et al.
Mengmeng Xu et al.
Objectives: FLASH radiotherapy is garnering attention for its capacity to diminish skin toxicity without compromising tumoricidal efficacy, presenting a stark contrast to conventional (CONV) radiotherapy. Despite its prom...