RSM-Based Optimization of Dose Response and Antibacterial Potential of Cannabis sativa (L.) Leaves Using Computational Analysis [0.03%]
基于RSM的优化剂量响应和大麻叶抗菌潜力的计算分析
Sara Zahid,Sampath Chinnam,Asma Ahmed et al.
Sara Zahid et al.
Background: In light of the growing problem of antibiotic resistance, it is imperative to investigate new sources, and plants offer a promising supply of bioactive chemicals. Because of its numerous uses in industry, heal...
Piperine Targets the FANCL/UBE2T Complex to Inhibit the FA Pathway and Sensitize Bladder Cancer to Cisplatin [0.03%]
曲菜素靶向FANCL/UBE2T复合体抑制FA通路及增加膀胱癌顺铂敏感性
Chen Li,Guanglin Lv,Ying Yue et al.
Chen Li et al.
Objectives: Platinum-based chemotherapy remains a mainstay for bladder cancer treatment, yet resistance often arises through activation of the Fanconi anemia (FA) DNA repair pathway. The monoubiquitination of the FANCI-FA...
Exploring the Therapeutic Potential of Virtual Screened Novel HER2 Inhibitors via QSAR, Molecular Docking and Dynamics Simulations [0.03%]
基于QSAR、分子对接及分子动力学模拟的HER2新型抑制剂虚拟筛选及药效研究
Khurram Rehman,Zoya Iqbal,Zhiqin Deng et al.
Khurram Rehman et al.
Objectives: HER2 overexpression is almost invariably associated with advanced breast cancer disease and poor prognosis, hence its extensive review. This study therefore aims to discover and analyze potential HER2 inhibito...
Is Indoor Air Pollution the Missing Link Between Radon and Lung Cancer? Rethinking Epidemiological Support for the LNT Model [0.03%]
室内空气污染是氡与肺癌之间的缺失环节吗？对LNT模式流行病学证据的再思考
Duk-Hee Lee
Duk-Hee Lee
The validity of the linear-no-threshold (LNT) model in radiation regulation remains contested. Although extensive experimental evidence challenges it, epidemiological studies-especially cohort and case-control designs-are still used to just...
Advancing Dose-Response Research: Integrating Exposome, Multi-Omics, and Low-Dose Phenomena in Toxicology and Medicine [0.03%]
推进剂量效应研究：毒理学和医学中暴露组、多组学和低剂量现象的整合
Lu Cai
Lu Cai
The field of dose-response research has evolved dramatically, propelled by advancements in exposomics concept, multi-omics technologies, and a growing appreciation of low-dose effects across disciplines. This editorial article highlights re...
Plasma miRNAome Profiling Reveals Candidate Biomarkers for Low- and High-Dose Whole-Body Ionizing Radiation Exposure [0.03%]
血浆miRNA谱分析发现低剂量和高剂量全身电离辐射照射的候选生物标志物
Gizelle J Lionel,Ronan Derbowka,Shayen Sreetharan et al.
Gizelle J Lionel et al.
Objective: MicroRNAs (miRNAs) are small, non-coding RNA molecules that regulate gene expression and remain stable in biological fluids, even under harsh conditions. Their stability and responsiveness to environmental stre...
Adaptive Responses in High-Radiation Environments: Insights From Chernobyl Wildlife and Ramsar Residents [0.03%]
高辐射环境中的适应性反应——来自切尔诺贝利野生动物和拉姆萨尔居民的启示
Smj Mortazavi,Sahel Rabiee,AmirAli Fallah et al.
Smj Mortazavi et al.
This mini-review explores adaptive responses in organisms exposed to high radiation levels, drawing comparisons between Chernobyl's wildlife-specifically its darker-pigmented frogs-and residents of Ramsar, Iran, a region with high natural b...
Verification of Preferred Reference Genes for RT-qPCR Analysis of Radiosensitivity Gene in Human Peripheral Blood [0.03%]
验证 radiosensitivity 相关基因的外周血中的参考基因用于 RT-qPCR 分析
Mingquan He,Xueqin Yang,Yuting Chen et al.
Mingquan He et al.
Objective: High-throughput gene expression analysis represents a promising approach for evaluating irradiation doses in vitro. This study aimed to identify preferred reference genes for normalizing RT-qPCR data in human p...
Lycium barbarum Polysaccharides Suppress Radiation-Induced Microglial Inflammation by Inhibiting the IKKβ/IκBα/NF-κB Pathway [0.03%]
枸杞多糖通过抑制IKKβ/IκBα/NF-κB信号通路干预辐射诱发的微胶质细胞炎症反应
Xing Zhang,Qun Liu,Lian Liu et al.
Xing Zhang et al.
Background: Radiation therapy for brain tumors often leads to radiation-induced brain injury, which is closely linked to microglial hyperactivation and neuroinflammation. Lycium barbarum polysaccharide (LBP), the primary ...
Pharmacological Intervention of Post-traumatic Seizure: Advanced Research Progress [0.03%]
创伤性癫痫的药理干预：最新研究进展
Weiwei Zeng,Juanfeng Ou,Ruitong Li et al.
Weiwei Zeng et al.
Traumatic brain injury (TBI) is an important condition with high rates of disability and mortality worldwide. Post-traumatic seizure (PTS) frequently occur following TBI, manifesting in both early and late stages. Recurrent PTS without time...