Radio-Protective Effect of Lanzhou Lily Polysaccharide on the Spleen in Mice [0.03%]
兰州百合多糖对辐射所致小鼠脾脏的保护作用
Zhong Guo,Jin Zhao,Lina Lu et al.
Zhong Guo et al.
Objectives: To investigate the protective effect and underlying mechanism of Lanzhou Lily Polysaccharide (LP) against radiation-induced splenic damage in mice. ...
Ginsenoside Rh2 Suppresses the Fanconi Anemia Pathway by Inhibiting NF-κB-Mediated FANCL Transcription in Bladder Cancer [0.03%]
Ginsenoside Rh2通过抑制NF-κB介导的FANCL转录抑制膀胱癌中Fanconi贫血途径
Chen Li,Guanglin Lv,Zhuang Xiong et al.
Chen Li et al.
Objectives: Cisplatin, a frontline chemotherapeutic agent for bladder cancer (BC), induces DNA interstrand crosslinks that are primarily repaired through the Fanconi anemia (FA) pathway. Hyperactivation of this repair mec...
Dosimetric Effect of Thymus on Radiation-Induced Lymphopenia in Breast Cancer Patients Who Received Adjuvant Radiotherapy [0.03%]
胸腺对接受术后放疗乳腺癌患者放射性淋巴细胞减少的剂量学效应研究
Tong Xia,Sisi Zheng,Jianjun Qian et al.
Tong Xia et al.
Background: Radiation-induced lymphopenia (RIL), particularly severe RIL (G3+), significantly impacts cancer outcomes. This retrospective study aimed to determine the role of irradiation dose to the thymus on RIL in breas...
Dose-Dependent Cardioprotection of Pterocarpus indicus Extract in Rats With Myocardial Ischemia: Targeting Oxidative Stress, Inflammation, and Apoptosis [0.03%]
Pterocarpus indicus提取物剂量依赖性心肌缺血保护作用的机制：针对氧化应激、炎症和细胞凋亡
Chen Yichun,Du Wen,Jin Weimeng et al.
Chen Yichun et al.
Background and aim: This study investigated the dose-dependent cardioprotective effects of Pterocarpus indicus extract (P.indicus; LD: 27, MD: 54, HD: 108 mg/kg) against isoproterenol (ISO)-induced myocardial ischemia in ...
U-Shaped Dose-Dependent Modulation of Macrophages by Ginkgolide B Mitigates Systemic Inflammation in Septic Rats [0.03%]
银杏内酯B剂量依赖性地调节巨噬细胞功能从而缓解脓毒症大鼠全身炎症反应
Zhaofeng Luo,Lan Ming,Jiamin Ji et al.
Zhaofeng Luo et al.
Objectives: This study delineates the U-Shaped Dose-Dependent Modulation of Ginkgolide B (GB) on macrophage function, highlighting its capacity to enhance bacterial phagocytosis and attenuate systemic inflammation in seps...
Growth Restriction in Balb/c Mice Irradiated With X-Rays During Late Gestation: Role of Irradiation Timing, Dose Fractionation and Adaptive Response [0.03%]
在妊娠晚期用X射线照射Balb/c小鼠的生长限制：辐照时间、剂量分割和适应性反应的作用
Shayenthiran Sreetharan,Trista King,Christopher Thome et al.
Shayenthiran Sreetharan et al.
Objectives: Exposure of the developing fetus to high doses of ionizing radiation during prenatal development can result in growth restriction of the fetus, or a reduction in offspring growth. The developmental stage of th...
The Value of Using 5T MRI T1ρ and T2 Mapping Sequences in Evaluating Muscle Changes Around Knee Osteoarthritis [0.03%]
5T MRI T1ρ和T2图谱序列评估膝骨关节炎周围肌肉变化的价值分析
Min Fu,Zhaohui Yin,Jie Gan et al.
Min Fu et al.
Objective: To explore the value of 5T magnetic resonance imaging (MRI) T1ρ and T2 mapping sequences in evaluating muscle changes around knee osteoarthritis (KOA). ...
TSN Disrupts Fanconi Anemia Pathway Activation Through JAK/STAT1-Mediated Transcriptional Repression of FA Core Subunits in Bladder Cancer [0.03%]
TSN通过JAK/STAT1介导的转录抑制作用压制Fanconi贫血通路组分基因表达从而抑制膀胱癌细胞生长
Wenchao Zhao,Zhiyuan Xie,Liang Zhu et al.
Wenchao Zhao et al.
Objectives: Resistance to platinum-based chemotherapy in bladder cancer is closely associated with activation of the Fanconi anemia (FA) DNA interstrand crosslink repair pathway. Identifying pharmacological inhibitors of ...
Towards Clinical Translation: Establishing Optimal Dose and Dose-Rate Parameters for the FLASH Skin-Sparing Effect [0.03%]
面向临床转化：建立FLASH皮肤保护效应的最佳剂量和剂量率参数
Yufeng Shen,Jie Zhou,Jinyi Lang et al.
Yufeng Shen et al.
Purpose: FLASH radiotherapy (FLASH-RT) has been reported to spare skin from acute radiation toxicity. However, systematic quantification is needed to determine the dose and dose-rate thresholds necessary for optimal radio...
Phenotypic Age Acceleration and Risk of All-Cause and Cardiovascular Mortality in US Adults With Asthma: A Retrospective Cohort Study [0.03%]
美国成年人哮喘患者表型年龄加速与全因和心血管死亡风险的关系：回顾性队列研究
Huijuan Cheng,Cuili Lin,Yanyan Ye et al.
Huijuan Cheng et al.
Background: Phenotypic age acceleration (PhenoAgeAccel) reflects biological aging, with higher values indicating faster aging. While linked to adverse outcomes in the general population, its relation to mortality in asthm...