Efficacy and Safety of Electroacupuncture Combined with Agomelatine Tablets Therapy in Treating Insomnia After Stroke [0.03%]
电针配合阿戈美拉汀片治疗卒中后失眠的疗效及安全性研究
Rui Han,Wenguang Wei
Rui Han
Insomnia, a common complication following stroke, significantly impairs patients' clinical outcomes. Electroacupuncture (EA), an advanced acupuncture technique, has demonstrated efficacy in alleviating insomnia symptoms. Agomelatine (AT), a...
Randomized Controlled Trial
Journal of molecular neuroscience : MN. 2025 Aug 9;75(3):102. DOI:10.1007/s12031-025-02394-9 2025
Finerenone Modulates PANoptosis to Improve Immune Microenvironment in Diabetic Nephropathy: A Machine Learning-Based Mechanistic Analysis [0.03%]
芬戈利蒙特在糖尿病肾病中调节PANoptosis以改善免疫微环境：基于机器学习的机制分析
Aihua Chen,Fenghua Wang
Aihua Chen
Diabetic nephropathy (DN) is characterized by nephron degeneration induced by hyperglycemia, driven by complex interactions between glucose metabolism dysregulation and immune microenvironment dynamics. This study employed machine learning ...
Genetic Association of CANT1 Gene with Scoliosis: An Integrative Study Involving Methylation, Immune Factors, and Metabolites [0.03%]
整合表观遗传、免疫和代谢数据的基因CANT1与脊柱侧凸相关性的研究
Xiao Zhang,Wenbo Gu,Yanrong Tian et al.
Xiao Zhang et al.
The CANT1 gene, encoding a nucleotidase linked to calcium signaling, is crucial for spinal development, with its deficiency causing skeletal developmental issues. However, the relationship between CANT1 and scoliosis remains unclear. This s...
Aggregation-Prone Pathogenic SOD1 Variants in Amyotrophic Lateral Sclerosis: Insights from Computational Genomics and Evolutionary Conservation [0.03%]
计算基因组学和进化保守性在渐冻症中病原SOD1变异体聚集的见解
Farah Anjum,Maha M Bakhuraysah,Maram Jameel Hulbah et al.
Farah Anjum et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive motor neuron degeneration and a median survival of 3-5 years post-diagnosis. While the etiology of ALS remains elusive, mutations in SOD1...
Gamma Oscillation Disruption Induced By Microglial Activation Contributes to Perioperative Neurocognitive Disorders in Aged Mice [0.03%]
老年小鼠术后神经认知障碍的机制研究：微胶质细胞活化诱导gamma振荡异常的作用及意义
Shiyu Hao,Qidi Zhang,Xianzheng Zhang et al.
Shiyu Hao et al.
Perioperative neurocognitive disorder (PND) is a prevalent postoperative complication of the central nervous system (CNS) in elderly patients. Advanced age is an independent risk factor for developing PND. Microglia are essential immune cel...
ZDHHC4 Influences Obsessive-Compulsive Disorder Risk Through Imaging-Derived Phenotypes: A Mendelian Randomization Study [0.03%]
锌指蛋白加帽酶C4通过影像表型影响强迫症风险的孟德尔随机化研究
Ying Huang,Huanxian Luo,Jieping Huang et al.
Ying Huang et al.
Obsessive-compulsive disorder (OCD) affects 1-3% of the global population and ranks among the top ten most disabling medical conditions. While abnormalities in cortico-striato-thalamo-cortical circuits have been implicated in OCD pathophysi...
Demographic, Clinical, and Molecular Determinants of Quality of Life and Oxidative Stress in Multiple Sclerosis: A Cross-Sectional Study from Sulaymaniyah, Iraq [0.03%]
伊拉克苏莱曼尼亚多发性硬化生活质量及氧化应激的病因：横断面研究
Dlzar Dlshad Ghafoor,Dlshad Omar Ahmed,Sarwer Jamal Al-Bajalan
Dlzar Dlshad Ghafoor
This is the first study in Iraq to integrate socioeconomic, genetic, and oxidative stress markers in MS patients, revealing unique associations between HLA-DRB1 polymorphisms and relapsing-remitting MS (RRMS). This work investigated the dem...
Transcriptomic Analysis of Immune-Related Genes in the Striatum of Parkinson's Disease Brain Across Mouse Strains [0.03%]
帕金森病小鼠不同品系纹状体免疫相关基因转录组分析
Shahid Ishaq,Iqbal Ali Shah,Shin-Da Lee et al.
Shahid Ishaq et al.
This study conducted a transcriptomic analysis to identify differentially expressed genes involved in immune-related pathways in the striatum of various Parkinson's disease (PD) mouse strains. Data were obtained from the NCBI GEO database, ...
Sleep Deprivation Induces Ferroptosis and Reduces the Expression of GABAB Receptor in Mice [0.03%]
睡眠剥夺诱导小鼠铁死亡及GABAB受体表达降低
Xinglong Lu,Zhenghua Wu,Xuanxuan Huang et al.
Xinglong Lu et al.
Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, has emerged as a critical mechanism underlying the pathophysiological effects of sleep deprivation (SD) and neurological consequences. Recent st...
Investigating Oxidative Stress and Impaired DNA Repair Capacity as Diagnostic Biomarkers in Autism Spectrum Disorder [0.03%]
自闭症谱系障碍中氧化应激和DNA修复能力缺陷的诊断生物标志物研究
Hawnaz Mohammad Ismael,Parween Abdulsamad Ismail
Hawnaz Mohammad Ismael
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by early-onset social communication deficits, restricted/repetitive behaviors, and sensory sensitivities. Although ASD is predominantly influenced by genetic fact...