Deep Neural Network-Based Risk Prediction of Glioblastoma Multiforme Recurrence [0.03%]
基于深度神经网络的多形性胶质母细胞瘤复发风险预测模型
Disha Sushant Wankhede,Aniket K Shahade,Priyanka V Deshmukh et al.
Disha Sushant Wankhede et al.
This study aims to develop and evaluate deep neural network (DNN) models for accurately predicting the recurrence risk of glioblastoma multiforme (GBM) to enhance individualized treatment strategies and improve patient outcomes. This study ...
Spinocerebellar Ataxia Type 1 (SCA1) Cell Models Display Widespread Mitochondrial and Extra-Nuclear Alterations [0.03%]
脊髓小脑性共济失调1型(SCA1)细胞模型显示线粒体和核外广泛变化
Dane Ford-Roshon,Madison Dudek,Ada Glynn et al.
Dane Ford-Roshon et al.
Ataxin-1 (ATXN1) is a nuclear-cytoplasmic shuttling protein, which, when expanded in its polyglutamine coding stretch, causes the progressive neurodegenerative disease Spinocerebellar Ataxia Type 1 (SCA1). While the role of nuclear ATXN1 as...
Higher Serum Aspartate May be Associated with Better Cognitive Function as Mediated by Reduced Aβ Accumulation in Frontal and Temporal Lobes in Mild Cognitive Impairment [0.03%]
轻度认知障碍患者血清天冬氨酸水平升高可能与以减少额叶和颞叶Aβ沉积为介导的更好的认知功能相关
Sarraa Ahmad Qahtan,Ali Fawzi Al-Hussainy,Vimal Arora et al.
Sarraa Ahmad Qahtan et al.
Aspartate, a key excitatory neurotransmitter, has shown conflicting links to cognitive disorders like Alzheimer's disease (AD) and mild cognitive impairment (MCI). Given its role in brain function, studying its relationship with amyloid-bet...
The Impact of Glutamatergic Excitotoxicity on the Differentiation of Cerebellar Neural Stem Cells [0.03%]
谷氨酸能兴奋毒性对小脑神经干细胞分化的影响
Grinev Egor,Shuvaev Andrey,Khilazheva Elena et al.
Grinev Egor et al.
The adult cerebellum retains a small Sox2/prominin-1 NSC pool whose fate is shaped by developmental cues and the glutamatergic milieu. We argue that glutamate excitotoxicity is the dominant negative regulator of this niche and Purkinje cell...
Iron and Ferritin Dyshomeostasis Intersect with Sex, Age, and Disease Severity in Amyotrophic Lateral Sclerosis [0.03%]
铁和 ferritin 同稳态失衡与性、年龄和肌萎缩侧索硬化严重程度之间的关系
Xiaoge Xie,Peng Wu,Ting Wen et al.
Xiaoge Xie et al.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, characterized by progressive loss of motor neurons. Due to heterogeneity in both cause and clinical phenotype, accuracy of diagnosis and efficacy of treatment remain ...
Comment on "Impact of AOC1 and HNMT Variants on the Therapeutic Outcomes of a Histamine Reducing Diet in Autism Spectrum Disorder" [0.03%]
关于“AOC1和HNMT变异对自闭症谱系障碍组胺减少饮食治疗效果影响”的评论
Rafia Raza,Arooba Khan
Rafia Raza
Kadiyska et al. recently investigated the impact of a histamine-reducing diet in children with autism spectrum disorder (ASD), with attention to potential modifying effects of AOC1 and HNMT gene variants. Although the study poses an importa...
Fluoxetine HCl-Loaded Nanostructured Lipid Carriers for Nose-to-Brain Delivery: Optimization and Synergistic Role of Saffron Oil [0.03%]
载有氟西汀的纳米结构脂质载体经鼻给药至大脑递送：优化及藏红花油的协同作用研究
Avinash R Tekade,Prasad V Kadam,Manoj K Aswar et al.
Avinash R Tekade et al.
Objectives: Depression is a widespread psychiatric condition marked by ongoing sadness, disinterest, insomnia, and thoughts of self-harm. Fluoxetine HCl (FH) is a frequently prescribed antidepressant; however, it has low ...
miR-146A and miR-146B Promoter Methylation and Common Sequence Variations Are Not Likely to Be Involved in Autism Spectrum Disorder [0.03%]
miR-146A和miR-146B的启动子甲基化及常见序列多态性可能不参与自闭症光谱障碍发病
Sohair M Salem,Nora N Ismaiel,Ammal M Metwally et al.
Sohair M Salem et al.
One of the well-studied epigenetic regulators is miRNA (miRNA) which plays critical roles in gene regulation and has been implicated in autism spectrum disorder (ASD) pathology, particularly through their involvement in neuroinflammation an...
Comprehensive in Silico Reclassification of MECP2 Variants of Uncertain Significance in Rett Syndrome: Performance Evaluation and Structural Analysis [0.03%]
雷特综合征MECP2变异位点的全面“线上”再分类：性能评估与结构分析
Sertaç Atalay,Özlem Yalçın Çapan
Sertaç Atalay
Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily caused by missense variants in the MECP2 gene. However, the presence of variants of uncertain significance (VUS) poses major challenges for clinical diagnosis and genetic...
RGS2-Related Non-coding Interaction Network Modulates the NF-Kappa B Signaling Pathway in MS Patients: A Systems Biology Investigation [0.03%]
系统生物学研究揭示RGS2相关非编码交互网络可调节多发性硬化患者的NF-kappa B信号通路
Parisa Forouzanfar,Mohammad Hashemian,Mojdeh Mahmoudian et al.
Parisa Forouzanfar et al.
Multiple sclerosis (MS) is the most common chronic inflammatory disease affecting the brain and spinal cord, with approximately 2.8 million cases globally. This study analyzed high-throughput MS datasets to identify dysregulated RNAs and vi...