An Investigation of the Causal Link Between Palmoylation Genes and Epilepsy Utilising Multi-omics Mendelian Randomisation Analysis and Validation Through Single-Cell Evidence [0.03%]
利用多组学孟德尔随机化分析并基于单细胞证据验证棕榈酰化基因与癫痫的因果关系研究
Jin Qiu,Dehai Xian,Kaiwen Yang
Jin Qiu
This work sought to examine the causal link between palmoyl-protein-modifying genes (ZDHHC family) and epilepsy by Mendelian randomisation (MR), utilising multi-level genomic data. A two-sample MR analysis was performed utilising publicly a...
Targeting Oligodendrocyte Dysfunction in Alzheimer's Disease: a New Frontier for Drug Repurposing with Antihistamines and Serotonin Receptor Agonists [0.03%]
针对阿尔茨海默病少突胶质细胞功能障碍的药物再利用新前沿：抗组胺药和血清素受体激动剂的作用
Sharanappa Gurikar,Syed Sagheer Ahmed,Bharathi Doddlu Raghunatahanaidu
Sharanappa Gurikar
Emerging data highlight oligodendrocyte dysfunction and myelin degeneration as early contributors to the pathology of Alzheimer's disease (AD), questioning the conventional neuron-focused amyloid-tau model. This comprehensive review recapit...
Transcriptome Profiling Across Multiple Organs Unveils Potential Regulatory Effects of C-Fibers on Host in Mice [0.03%]
跨多器官转录组分析揭示C纤维对宿主的潜在调节作用
Yu He,Changgen Li,Jianhua Wei et al.
Yu He et al.
As nociceptors, C-fibers play a critical role in maintaining host homeostasis under both physiological and pathological conditions. We previously demonstrated that C-fiber degeneration confers protection against respiratory syncytial virus ...
Exosome/Extracellular Vesicles-Based Therapeutics in Alzheimer's Disease: Neuroprotective Roles and Future Perspectives [0.03%]
外泌体/细胞外囊泡在阿尔茨海默病治疗中的神经保护作用及未来前景
Negar Ebadpour,Mohammad Abavisani,Sercan Karav et al.
Negar Ebadpour et al.
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is marked by memory loss, cognitive decline, and characteristic pathological features including β-amyloid (Aβ) plaques, tau tangles, and neuroinflammation. Despite extens...
The ADNP-Mediated Transcriptome Response to Ketamine Impairs the Cytoskeletal Protein Axis [0.03%]
与氯胺酮共处理的ADNP介导的转录组反应破坏细胞骨架蛋白轴
Claudio Peter D&#x;Incal,Ligia Mateiu,Kevin De Man et al.
Claudio Peter D&#x;Incal et al.
De novo variants in the Activity-Dependent Neuroprotective Protein (ADNP) gene cause the autistic Helsmoortel-Van der Aa syndrome with patients showing mild to disastrous phenotypes impacting brain functioning, behavior, and organ functions...
An Investigation of the Levels of Serine Protease and Associated Molecules in Children with Autism Spectrum Disorder [0.03%]
自闭症患儿丝氨酸蛋白酶及其相关分子水平的研究
Merve Yaylaci,Ozlem Dogan,Fatma Zehra Kirşan et al.
Merve Yaylaci et al.
This study aimed to elucidate the potential role of serine proteases and their associated regulatory molecules in the etiopathogenesis of autism spectrum disorder (ASD) and to assess their relationship with symptom severity and specific beh...
An Investigation of the Levels of Serine Protease and Associated Molecules in Children with Autism Spectrum Disorder [0.03%]
自闭症患儿中蛋白酶及相应分子的变化研究
Merve Yaylaci,Ozlem Dogan,Fatma Zehra Kirşan et al.
Merve Yaylaci et al.
This study aimed to elucidate the potential role of serine proteases and their associated regulatory molecules in the etiopathogenesis of autism spectrum disorder (ASD) and to assess their relationship with symptom severity and specific beh...
Genetic Abnormalities in Neurodevelopmental Disorders with Multidimensional Impairment [0.03%]
多维度缺陷神经发育障碍的遗传异常
Cyril Hanin,Paloma Torres,Isabelle Millet et al.
Cyril Hanin et al.
Objectives: Many children with neurodevelopmental disorders (NDD) show complex, multidimensional impairments meeting criteria for multiple NDD, yet remain "diagnostically homeless" as DSM-5 lacks a Multidimensional Impair...
Genetic Abnormalities in Neurodevelopmental Disorders with Multidimensional Impairment [0.03%]
多维度损伤神经发育障碍的遗传异常
Cyril Hanin,Paloma Torres,Isabelle Millet et al.
Cyril Hanin et al.
Objectives: Many children with neurodevelopmental disorders (NDD) show complex, multidimensional impairments meeting criteria for multiple NDD, yet remain "diagnostically homeless" as DSM-5 lacks a Multidimensional Impair...
Can Oxidative Stress Biomarkers Differentiate Trichotillomania from Obsessive-Compulsive Disorder and Healthy Controls? [0.03%]
氧化应激生物标志物能区分拔毛症和强迫症及健康对照吗？
Yusuf Selman Çelik,Hande Günal Okumuş,Meryem Kaşak et al.
Yusuf Selman Çelik et al.
This study investigated oxidative stress biomarkers in differentiating trichotillomania (TTM), obsessive-compulsive disorder (OCD), and healthy controls (HC), focusing on thiol-disulfide homeostasis, total oxidant status (TOS), total antiox...