Effects of Treatment with Dexmedetomidine on Neurochemical and Cognitive Alterations Induced by Sepsis in an Animal Model [0.03%]
右美托咪啶对感染性休克致神经化学和认知功能损伤的治疗效应研究
Mariane Abatti,Luana Cucker,Andriele Vieira et al.
Mariane Abatti et al.
An Improved Deep Semi-supervised JNMF Method for Biomarker Extraction of Alzheimer's Disease [0.03%]
一种改进的深度半监督JNMF方法提取阿尔茨海默病生物标志物
Yawen Chen,Wei Kong,Kun Liu et al.
Yawen Chen et al.
Imaging genetics is an approach that explores the underlying mechanisms of brain disorders such as Alzheimer's disease (AD) by analyzing the correlation between neuroimaging and genetic data. Traditional non-negative matrix factorization (N...
A Multi-Ancestry GWAS Meta-Analysis Integrated with In-Depth Silico, Systems Biology, and Pharmacogenomics Approaches on Alzheimer's Disease Among 1,198,689 Subjects [0.03%]
基于深度计算和系统生物学及药物基因组学方法的阿尔茨海默病多祖先GWASmeta分析（共纳入1,198,689人）
Alireza Sharafshah,Sajjad Rezaei
Alireza Sharafshah
This study aimed to perform a Meta-Analysis based on GWAS data and utilized them for multi-step analyses. Final data included 1,198,682 subjects (255,810 cases and 942,872 controls) in 26 studies among 11 ethnicities. R package utilized for...
The Dynamic UPR Rheostat Orchestrates Single-Cell Plasticity in Glioblastoma [0.03%]
动态UPR rheostat调控胶质母细胞瘤单细胞可塑性
Zekeriya Duzgun
Zekeriya Duzgun
Glioblastoma (GBM) adapts to microenvironmental stress through the unfolded protein response (UPR), yet whether the three canonical arms IRE1/XBP1, ATF6, and PERK operate as a graded control system at single-cell resolution remains unclear....
Do Glioma Cells Rewire Neural Circuits through Epigenetic Changes? DNA Methylation Analysis of Genes Involved in Neuron-Glioma Communication in the Human Frontal Cortex [0.03%]
低级别胶质瘤细胞通过表观遗传重编程神经环路吗？人类 frontal cortex 中参与神经元-胶质瘤通讯基因的DNA甲基化分析
Vida Kassaeyan,Farzin Tahmasbi Arashlow,Sepide Ahmadi et al.
Vida Kassaeyan et al.
Gliomas are known to form connections with nearby neurons, which help drive their own growth. What is less clear is how these tumor cells adapt at the molecular level to join neural circuits. We investigated whether changes in DNA methylati...
Irilone and Lupinisoflavone C as Potential Plant-Based Modulators of S1PR1 for Neuroimmune Modulation in Multiple Sclerosis: Insights from Molecular Docking and Dynamics [0.03%]
基于分子对接和动力学的植物源S1PR1调控剂艾立龙和 Lupinisoflavone C 潜在用于调节多发性硬化症神经免疫功能的研究展望
Taghreed A Majrashi,Abdulrhman Alsayari,Mohammad Y Alshahrani et al.
Taghreed A Majrashi et al.
The S1PR1 gene encodes the sphingosine-1-phosphate receptor 1, a member of the G protein-coupled receptor (GPCR) family that is highly expressed in endothelial cells. S1PR1 protein plays a pivotal role in regulating cell migration, maintain...
Hypocitrullinemia as an Early Diagnostic Biomarker for MT-ATP6 Mitochondrial Diseases [0.03%]
MT-ATP6型线粒体病的早期诊断标志物——瓜氨酸升高症候群
Yingxue Li,Dongjuan Wang,Maobin Zhou et al.
Yingxue Li et al.
MT-ATP6 mitochondrial diseases are a group of disorders inherited from the maternal lineage caused by pathogenic variants in the MT-ATP6 gene, which encodes the a subunit of mitochondrial complex V (ATP synthase) in the electron transport c...
Integrated Bioinformatics Analyses of Peripheral Blood Transcriptomes Reveals Shared Molecular Features Underlying the Comorbidity of Schizophrenia and Metabolic Syndrome [0.03%]
基于外周血转录组的综合生物信息学分析揭示了精神分裂症和代谢综合征共病的分子特征
Yue Zhang,Mengmeng Hao,Yanwei Hu
Yue Zhang
Patients with schizophrenia (SCZ) exhibit a significantly higher prevalence of metabolic syndrome (MetS), suggesting a potential biological link between the two conditions. However, the molecular mechanisms underlying this comorbidity remai...
Tissue Plasminogen Activator as an Approved Strategy for Ischemic Stroke: A Review of tPA's Structure, Mechanism of Action and the Novel Targeting Methods [0.03%]
组织型纤溶酶原激活剂作为缺血性卒中的获批策略：tPA的结构、作用机制及新型靶向方法综述
Kimia Didehvar,Mehdi Haghshenas,Reyhaneh Yarmohammadi et al.
Kimia Didehvar et al.
Tissue-type plasminogen activator (tPA) is a serine protease that contains five functional domains, and it acts through influencing different substrates, binding proteins, and receptors. Studies revealed that tPA has been observed to have b...
Machine Learning Identifies FLNA as a Key Molecular Target Regulating Neuronal Apoptosis after Spinal Cord Injury [0.03%]
机器学习鉴定FLNA为调控脊髓损伤后神经元凋亡的关键分子靶点
Yingfan Pei,Yaorui Hu,Guoying Feng et al.
Yingfan Pei et al.
Spinal cord injury (SCI), a traumatic type of central nervous system injury, is closely associated with neuronal apoptosis. However, the specific biomarkers and regulatory mechanisms of neuronal apoptosis in SCI patients remain unclear. In ...