C1QTNF6 Targeted by MiR-184 Regulates the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells [0.03%]
靶向C1QTNF6的MiR-184调节肺腺癌细胞的增殖、迁移和侵袭作用
Xiao Rao,Yunping Lu
Xiao Rao
Objective: To seek out the mechanism by which C1QTNF6 mediates lung adenocarcinoma (LUAD). Methods: Differentially expressed mRNAs and ...
Novel Salt-Tolerant Leucine Dehydrogenase from Marine Pseudoalteromonas rubra DSM 6842 [0.03%]
来源于海洋Pseudoalteromonas rubra DSM 6842的新型耐盐型亮氨酸脱氢酶
Rui Chen,Yu-Ting Liao,Tian-Tian Gao et al.
Rui Chen et al.
This study reported the cloning, expression, and characterization of a new salt-tolerant leucine dehydrogenase (PrLeuDH) from Pseudoalteromonas rubra DSM 6842. A codon-optimized 1038 bp gene encoding PrLeuDH was successfully expressed on pE...
LncRNA ARAP1-AS1 Promotes Bladder Cancer Development by Regulating the miR-3918/KIF20A Axis [0.03%]
长链非编码RNA ARAP1-AS1通过调节miR-3918/KIF20A轴促进膀胱癌发生发展
Wei Zhang,Jingyu Zhang,Zhi Hu et al.
Wei Zhang et al.
This study is to clarify the effect of the long non-coding RNA ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1-antisense RNA 1 (ARAP1-AS1)/microRNA (miR)-3918/kinesin family member 20A (KIF20A) on bladder cancer cell function. ARA...
Genetic Diversity Assessment of Iranian Kentucky Bluegrass Accessions: I. ISSR Markers and Their Association with Habitat Suitability Within and Between Different Ecoregions [0.03%]
伊朗雀麦种质资源遗传多样性评估(ISSR标记及其在不同生态区域内的居群遗传多样性和生境适应性关联分析)
Mohammad A Ghanbari,Hassan Salehi,Ali Moghadam
Mohammad A Ghanbari
Poa pratensis L. is a commonly used cool-season turfgrass and endemic to Iran. This research was carried out to examine the genetic diversity of this plant within and between ecoregions of Iran and the impact of climatic variables and eleva...
MiR-99a-5p Constrains Epithelial-Mesenchymal Transition of Cervical Squamous Cell Carcinoma Via Targeting CDC25A/IL6 [0.03%]
微RNA-99a-5p通过靶向细胞周期素_dependency激活激酶25A/白细胞介素6抑制宫颈鳞状细胞癌的上皮_间充质转化
Ailing Gu,Xudong Bao
Ailing Gu
MiR-99a-5p participates in processes and pathogenesis of varying diseases. However, the molecular mechanism of miR-99a-5p in human cervical squamous cell carcinoma (CSCC) remains unclear. Here, we found that miR-99a-5p was lowly expressed i...
One-Step Genotyping Method in loxP-Based Conditional Knockout Mice Generated by CRISPR-Cas9 Technology [0.03%]
基于CRISPR-Cas9技术的loxP条件性基因敲除小鼠的一步基因分型方法
He Zhu,Siqian Liu,Wenxi He et al.
He Zhu et al.
With the development of CRISPR-Cas9 gene editing and in vitro fertilization (IVF) technology, we can now easily construct genetically modified mouse strains with indels, especially for loxP-based strategy. However, the general genotyping me...
Peyman Habibi,Yao Shi,Maria Fatima Grossi-de-Sa et al.
Peyman Habibi et al.
Malaria is one of the severe infectious diseases that has victimized about half a civilization billion people each year worldwide. The application of long-lasting insecticides is the main strategy to control malaria; however, a surge in ant...
Production and Conjugation of Truncated Recombinant Diphtheria Toxin to VEGFR-2 Specific Nanobody and Evaluation of its Cytotoxic Effect on PC-3 Cell Line [0.03%]
截短的白喉毒素与VEGFR-2特异性单域抗体的融合及对PC-3细胞株的体外细胞毒性实验研究
Samira Shajari,Mohammad Morad Farajollahi,Mahdi Behdani et al.
Samira Shajari et al.
Immunotoxins have represented a great potency in targeted therapeutics to encounter tumors. They consist of a protein toxin conjugated to a targeting moiety, which recognizes a specific antigen on surface of cancer cells and accordingly ind...
Construction and Quantitative Evaluation of a Tissue-Specific Sleeping Beauty by EDL2-Specific Transposase Expression in Esophageal Squamous Carcinoma Cell Line KYSE-30 [0.03%]
在食管鳞癌细胞系KYSE-30中构建组织特异性“睡眠剥夺”系统及定量评价
Reihaneh Alsadat Mahmoudian,Fardin Fathi,Moein Farshchian et al.
Reihaneh Alsadat Mahmoudian et al.
Gene delivery to esophageal tissue could provide novel treatments for diseases, such as cancer. The Sleeping Beauty (SB) transposon system, as a natural and non-viral tool, is efficient at transferring transgene into the human genome for hu...
An Insight into Modern Targeted Genome-Editing Technologies with a Special Focus on CRISPR/Cas9 and its Applications [0.03%]
现代基因组编辑技术的透视——以CRISPR/Cas9及其应用为例
Fatima Akram,Sania Sahreen,Farheen Aamir et al.
Fatima Akram et al.
Genome-editing technology has enabled scientists to make changes in model organisms' DNA at the genomic level to get biotechnologically important products from them. Most commonly employed technologies for this purpose are transcription act...