Heterologous Expression and Characterization of a Full-length Protozoan Nitroreductase from Leishmania orientalis isolate PCM2 [0.03%]
分离自莱什曼原虫PCM2菌株的全长真核硝基还原酶的异源表达及鉴定
Panu Pimviriyakul,Yuvarun Kapaothong,Theerapat Tangsupatawat
Panu Pimviriyakul
Leishmaniasis, a parasitic disease found in parts of the tropics and subtropics, is caused by Leishmania protozoa infection. Nitroreductases (NTRs), enzymes involved in nitroaromatic prodrug activation, are attractive targets for leishmania...
Overexpression of ST7-AS1 Enhances Apoptosis and Inhibits Proliferation of Papillary Thyroid Carcinoma Cells Via microRNA-181b-5p-Dependent Inhibition Tripartite Motif Containing 3 [0.03%]
ST7-AS1过表达通过依赖微小核糖核酸-181b-5p的三聚体 motif 结合域3抑制作用增强乳头状甲状腺癌细胞凋亡和增殖抑制
Yuan Zhao,Xiaoyun Feng,Yonggang Zhao et al.
Yuan Zhao et al.
Long non-coding RNAs (lncRNAs) are of great significance in the pathogenesis and progression of papillary thyroid carcinoma (PTC). LncRNA tumorigenicity 7 antisense RNA 1 (ST7-AS1) is a newly identified lncRNA serving as an oncogene or tumo...
Recent Advances and Therapeutic Strategies Using CRISPR Genome Editing Technique for the Treatment of Cancer [0.03%]
利用CRISPR基因编辑技术治疗癌症的最新进展和治疗策略
Shreyasi Maity,Rishyani Mukherjee,Satarupa Banerjee
Shreyasi Maity
CRISPR genome editing technique has the potential to target cancer cells in a precise manner. The latest advancements have helped to address one of the prominent concerns about this strategy which is the off-target integrations observed wit...
DEAE-Dextran Enhances the Lentiviral Transduction of Primary Human Mesenchymal Stromal Cells from All Major Tissue Sources Without Affecting Their Proliferation and Phenotype [0.03%]
二氨基乙醇葡聚糖能使来源于所有主要组织的人骨髓间充质干细胞转导率增强，而不影响细胞的增殖和表型属性
Francesco Amadeo,Vivien Hanson,Patricia Murray et al.
Francesco Amadeo et al.
Genetic engineering of mesenchymal stromal cells (MSCs) is a tool widely used to explore MSC properties in vitro and in vivo. Lentiviral infection with the use of polycations as an adjuvant is a method that is commonly used to generate stab...
Landscape of Clinically Relevant Exosomal tRNA-Derived Non-coding RNAs [0.03%]
临床相关外泌体tRNA衍生非编码RNA的景观分析
Padmanaban S Suresh,Sanu Thankachan,Thejaswini Venkatesh
Padmanaban S Suresh
Exosomes are extra-cellular vesicles that are < 150 nm that is formed by invagination of the plasma membrane and are released as vesicles. These contain proteins, RNA, and DNA as their cargo. In recent times, the non-coding RNA (ncRNA) pres...
Identification of Key Gene Network Modules and Hub Genes Associated with Wheat Response to Biotic Stress Using Combined Microarray Meta-analysis and WGCN Analysis [0.03%]
基于联合微阵列meta分析和WGCNA分析的生物胁迫响应基因网络模块及关键节点基因鉴定
Mahdi Nemati,Nasser Zare,Nemat Hedayat-Evrigh et al.
Mahdi Nemati et al.
Wheat (Triticum aestivum) is one of the major crops worldwide and a primary source of calories for human food. Biotic stresses such as fungi, bacteria, and diseases limit wheat production. Although plant breeding and genetic engineering for...
Circ_0001982 Up-regulates the Expression of E2F1 by Adsorbing miR-1205 to Facilitate the Progression of Glioma [0.03%]
circ_0001982通过吸附miR-1205上调E2F1表达促进胶质瘤进展
Zhihui Ma,Jinyang Ma,Bojuan Lang et al.
Zhihui Ma et al.
This study was aimed at probing into the regulatory effects of circular RNA (circRNA)_0001982 on glioma cell proliferation, migration, invasion, and cell cycle, and its underlying mechanism. CircRNA expression profile of glioma tissues/norm...
LncRNA SNHG16 is Downregulated in Pneumonia and Downregulates miR-210 to Promote LPS-Induced Lung Cell Apoptosis [0.03%]
长链非编码RNA SNHG16在肺炎中下调并通过下调miR-210促进LPS诱导的肺细胞凋亡
Panjun Gao,Jing Wang,Ming Jiang et al.
Panjun Gao et al.
Long non-coding RNA Small Nucleolar RNA Host Gene 16 (SNHG16) has been reported to participate in Lipopolysaccharide (LPS)-induced inflammatory pathway, which contributes to pneumonia. This study was therefore conducted to explore the role ...
RHAU Peptides Specific for Parallel G-Quadruplexes: Potential Applications in Chemical Biology [0.03%]
用于平行G-四链体的RHAU肽：化学生物学中的潜在应用
Le Tuan Anh Nguyen,Dung Thanh Dang
Le Tuan Anh Nguyen
G-quadruplexes (G4s) are non-canonical nucleic acid structures formed by guanine (G)-rich sequences, which are ubiquitously found in the human genome and transcriptome. Targeting G4s by specific ligands provides a powerful tool to monitor a...
Evaluation of Growth and Utilization Potential of Rhodobacter sphaeroides in Reused Medium [0.03%]
Rhodobacter sphaeroides 在重复培养基中的生长及应用潜能评估研究
Jaeyoung Yu,Ju-Yong Park,Yang-Hoon Kim et al.
Jaeyoung Yu et al.
Rhodobacter sphaeroides is a metabolically versatile purple non-sulfur bacteria that can produce valuable substances. As the low-cost and high-efficiency production of valuable substances is attracting attention, the reuse of the medium is ...