Sequence-Specific Gene Silencing of acrA in the Multi-drug Efflux System AcrAB Induces Sensitivity in Drug-Resistant Klebsiella pneumoniae [0.03%]
多药外排系统AcrAB中acrA基因的序列特异性基因沉默可使耐药肺炎克雷伯菌产生敏感性
Priyanka Ashwath,Vijaya Kumar Deekshit,Anusha Rohit et al.
Priyanka Ashwath et al.
Multi-drug efflux is one of the resistant determinants in Klebsiella pneumoniae that are encountered in a broad range of clinically relevant antimicrobial agents. An alternative method to strategically induce sensitivity in drug-resistant K...
CircTFF1 Promotes Proliferation, Migration and Invasion of Lung Cancer Cells by Facilitating Methylation of BCL6B Promoter via miR-29c-3p/DNMT3A Axis [0.03%]
circTFF1通过miR-29c-3p/DNMT3A轴促进BCL6B启动子甲基化从而促进肺癌细胞的增殖，迁移和侵袭
Lantao Zhao,Hongya Xie,Peng Li et al.
Lantao Zhao et al.
Lung cancer exists as a major risk of cancer-related death worldwide. As a novel circular RNA (circRNA), circTFF1 has not been explored in lung cancer thoroughly. This study aims to probe into the function and mechanism of circTFF1 in lung ...
Sensitive and Portable Detection of Bacteria Using Exonuclease-III (Exo-III) Assisted Signal Amplification and Personal Glucose Meters [0.03%]
利用外切酶Ⅲ辅助信号放大和个人血糖仪检测细菌的敏感和便携方法
Xijun Weng,Jiangyong Lou,Jing Zhang et al.
Xijun Weng et al.
Despite major advances in combating pathogenic bacteria caused infection, infectious diseases remain a major cause of death today. A variety of bacteria detection approaches have been established by exploiting the aptamer to specifically id...
Proteome-Based Investigation Identified Potential Drug Repurposable Small Molecules Against Monkeypox Disease [0.03%]
基于蛋白质组的研究发现了可能对猴痘疾病有治疗潜力的药物分子
Arittra Bhattacharjee,Ishtiaque Ahammad,Zeshan Mahmud Chowdhury et al.
Arittra Bhattacharjee et al.
Monkeypox Virus (MPXV), the causative agent of Monkeypox (MPX) disease, is an emerging zoonotic pathogen spreading in different endemic and non-endemic nations and creating outbreaks. MPX treatment mainly includes Cidofovir and Tecovirimat ...
MiR-29c-3p/C1QTNF6 Restrains the Angiogenesis and Cell Proliferation, Migration and Invasion in Head and Neck Squamous Cell Carcinoma [0.03%]
miR-29c-3p/C1QTNF6抑制头颈部鳞状细胞癌的血管生成及细胞增殖、迁移和侵袭作用
Fang Huang,Hui Qi
Fang Huang
In our research, we studied the regulatory effect of miR-29c-3p on HNSCC progression. First, bioinformatics approach was utilized to find significantly differentially expressed genes in The Cancer Genome Atlas-HNSCC. Then the target miRNA a...
Identification and Preliminary Characterization of a Novel Single-Stranded DNA Binding Protein of Staphylococcus aureus Phage Phi11 Expressed in Escherichia coli [0.03%]
金黄色葡萄球菌噬菌体Phi11的一种新型单链DNA结合蛋白的鉴定和初步特征分析在大肠杆菌中的表达
Vivek Ratre,Vijay Hemmadi,Sumit Biswas et al.
Vivek Ratre et al.
Bacteriophage Phi11 harbors a gene, gp13, encoding the putative SSB protein (GenBank accession no. NC_004615.1). SSB proteins bind to and protect the single-stranded DNA molecules from nuclease digestion and are essential for the growth and...
Long Non-coding RNA SPAG5-AS1 Attenuates Diabetic Retinal Vascular Dysfunction by Inhibiting Human Retinal Microvascular Endothelial Cell Proliferation, Migration, and Tube Formation by Regulating the MicroRNA-1224-5p/IRS-1 Axis [0.03%]
长链非编码RNA SPAG5-AS1通过调节微RNA-1224-5p/IRS-1轴抑制人视网膜微血管内皮细胞的增殖、迁移和管形成，从而减轻糖尿病视网膜血管功能障碍
XingJie Su,XiaoTian Yang,HongWei Liu
XingJie Su
Diabetic retinopathy (DR) is causal for visual impairment and blindness. The research aimed at whether and how lncRNA SPAG5-AS1 (SPAG5-AS1) is involved in retinal vascular dysfunction under diabetic conditions. After determination of SPAG5-...
E3 Ubiquitin Ligase RNF125 Suppresses Immune Escape in Head and Neck Squamous Cell Carcinoma by Regulating PD-L1 Expression [0.03%]
E3泛素连接酶RNF125通过调控PD-L1的表达抑制头颈部鳞状细胞癌的免疫逃逸
Cuihong Jiang,Lili He,Shuai Xiao et al.
Cuihong Jiang et al.
Head and neck squamous cell carcinoma (HNSCC) is a lethal malignancy. Given the essential roles of E3 ligases in cancer immunotherapies, this paper explored the effect of E3 ubiquitin ligase ring finger protein 125 (RNF125) on immune escape...
2'-Hydroxy-4',5'-dimethoxyacetophenone Exhibit Collagenase, Aldose Reductase Inhibition, and Anticancer Activity Against Human Leukemic Cells: An In Vitro, and In Silico Study [0.03%]
2′-羟基-4'，5′-二甲氧基乙酰苯酮表现出胶原酶、醛糖还原酶抑制和抗癌活性对抗人白血病细胞：体外和计算机模拟研究
Yingna Chu,Juan Xiao
Yingna Chu
Diabetes is a serious growing concern that affects many parts of the body including the skin due to high sugar levels. Moreover, diabetic patients are at risk of developing cancer and are prone to a higher risk of hematological malignancies...
An Appraisal on Prominent Industrial and Biotechnological Applications of Bacterial Lipases [0.03%]
细菌脂酶的突出工业和生物技术应用评价
Fatima Akram,Azka Shahzad Mir,Ikram Ul Haq et al.
Fatima Akram et al.
Microbial lipases expedite the hydrolysis and synthesis of long-chain acyl esters. They are highly significant commercial biocatalysts to biotechnologists and organic chemists. The market size of lipase is anticipated to reach $590 million ...