Comprehensive Multi-omics and Mendelian Randomization Reveal the Key Role of Monocytes in Aging and Osteoarthritis [0.03%]
综合多种组学和孟德尔随机化揭示单核细胞在衰老和骨关节炎中的关键作用
Xiangwen Shi,Linmeng Tang,Mingjun Li et al.
Xiangwen Shi et al.
There is a close connection between aging and osteoarthritis (OA), but the specific mechanisms are still unclear. This study aims to explore the potential connections and molecular mechanisms between OA and aging through multi-omics and gen...
Evolution and Impact of Imine Reductases (IREDs) Research: A Knowledge Mapping Approach [0.03%]
基于知识图谱的亚胺还原酶(IREDs)研究进展与影响分析
Qilong Yao,Yujun Hu,Ziwei Liu et al.
Qilong Yao et al.
Nitrogen-containing compounds, particularly those with chiral amine structures, play a crucial role in the development of organic active pharmaceutical ingredients. Imine reductases (IREDs), NAD(P)H-dependent enzymes that catalyze the reduc...
A New Anatomical Nano Interbody Fusion Device for Elderly Patients Undergoing Anterior Discectomy and Interbody Fusion [0.03%]
一种新型解剖 nano 间盘融合装置用于老年人前入路摘除术及椎体间融合手术
Shuang Tian,Pengliang Xu
Shuang Tian
To evaluate the perioperative outcomes of a novel anatomical nano-cage in elderly patients undergoing anterior discectomy and interbody fusion, with special attention to its outcomes on clinical symptoms, interbody fusion stability, and sur...
SIRT5 Inhibits Mitophagy and Inflammation of Hypoxia-Induced Pulmonary Hypertension by Regulating the Desuccinylation of PDK1 [0.03%]
SIRT5通过调节PDK1脱琥珀酰化抑制缺氧诱导的肺动脉高压中的线粒体自噬和炎症
Lin Guo,Kangkang Ji,Yi Yin
Lin Guo
Hypoxia-induced pulmonary hypertension (HPH), a consequence of lung pathologies, is linked to changes in immune responses and inflammation. SIRT5 is recognized as the only enzyme capable of removing succinyl groups. The focus of this resear...
Transgenesis in Drug Discovery: Enhancing Target Identification and Validation [0.03%]
转基因技术在药物发现中的应用：增强靶点识别和验证
Rumela Mete,Sourav Das,Arindam Saha et al.
Rumela Mete et al.
Transgenesis, the introduction of foreign genetic material into the genome of an organism, has become a crucial and transformative technique in the realm of drug discovery. This review article provides a comprehensive overview of the integr...
Efficacy and Safety of High-Dose Erythropoietin Combined with Hypothermia Therapy in Neonatal Hypoxic-Ischemic Encephalopathy: A Systematic Review and Meta-Analysis [0.03%]
高剂量促红细胞生成素联合亚低温治疗新生儿缺氧缺血性脑病的有效性和安全性：系统评价和Meta分析
Mengzao He,Yejun Zhao,Jinping Jiang et al.
Mengzao He et al.
This study was conducted to systematically evaluate the effectiveness and safety of high-dose erythropoietin (EPO) combined with hypothermia in treating neonatal hypoxic-ischemic encephalopathy (HIE) using meta-analysis (MA) and providing i...
From Motor Proteins to Oncogenic Factors: The Evolving Role of Kinesin Superfamily Proteins in Breast Cancer Development [0.03%]
从分子马达蛋白到致癌因子：动力蛋白超家族在乳腺癌发展中角色的演变
Mohamed J Saadh,Hanan Hassan Ahmed,Radhwan Abdul Kareem et al.
Mohamed J Saadh et al.
The kinesin family of proteins (KIFs), known for their role as motor proteins, is integral to transporting cargo within cells along microtubule tracks, which is crucial for processes, such as cell division, differentiation, and intracellula...
Therapeutic Potential of NF-κB Inhibition in Glioblastoma: Gene Therapy Approach with rAAV-5 Mediated IκBαM Overexpression [0.03%]
NF-κB抑制在胶质母细胞瘤中的治疗潜力：使用rAAV-5介导的IκBαM过表达的基因疗法方法
Ceera Manikandan,Amit Kumar Jaiswal
Ceera Manikandan
Current treatment strategies for glioblastoma, including resection followed by concurrent chemotherapy/radiotherapy are not curative. Angiogenesis and hypoxia are two major factors responsible for GBM growth and resistance to existing thera...
Marine Carotenoids: Unlocking Advanced Antioxidant Mechanisms and Therapeutic Applications for Oxidative Stress [0.03%]
海洋类胡萝卜素：解锁高级抗氧化机制及氧化应激的治疗应用
Fatima Iftikhar Shah,Hassan Imran,Fatima Akram et al.
Fatima Iftikhar Shah et al.
Marine ecosystems are a rich source of bioactive compounds, with carotenoids like astaxanthin, fucoxanthin, and zeaxanthin demonstrating significant antioxidant properties. These carotenoids neutralize reactive oxygen species (ROS), protect...
Unveiling the Hub Genes Associated with the Enhanced Effects of Selenium on Pancreas Function in Diabetic Mice [0.03%]
揭示硒对糖尿病小鼠胰腺功能增强效应相关的中心基因
Xiaofeng Li,Zhihao Chen,Tao Wang et al.
Xiaofeng Li et al.
To elucidate the molecular mechanisms underlying the protective effects of selenium on pancreatic function in diabetes mellitus, we performed a comprehensive bioinformatics analysis of the GSE55636 dataset from the Gene Expression Omnibus (...