Construction and Multi-dimensional Validation of a Lactylation-Related Signature for Glioblastoma Multiforme Prognostic and Therapeutic Purposes [0.03%]
胶质母细胞瘤乳酰化相关特征的构建及多维度验证以期改善患者的预后和治疗效果
Wenjie Wen,Jiongxue Chen,Fuyin Deng et al.
Wenjie Wen et al.
Glioblastoma multiforme, one of the most malignant types of brain tumor, heavily relies on glycolytic pathways and is significantly influenced by immune infiltration and its surrounding microenvironment. Growing evidence implies that increa...
Overexpression of OsCCR1, OsCOMT5, OsCAD2 and OsCCoAOMT1 Genes Enhances Lignin Accumulation and Confers Tolerance Against Rhizoctonia solani in Rice (Oryza sativa) [0.03%]
OsCCR1、OsCOMT5、OsCAD2和OsCCoAOMT1基因的过表达增强了水稻的木质素积累并使其具有抗立枯丝核菌的性状(Oryza sativa)
Gurdeep Kaur,Gurbir Kaur Sidhu,Anjulata Singh et al.
Gurdeep Kaur et al.
The necrotrophic fungus, Rhizoctonia solani is the major cause of sheath blight, a disease that leads to a significant reduction in rice yield, posing a serious threat to food security. Traditional breeding approaches have struggled to deve...
Curcumin Inhibits Lipopolysaccharide-Induced Inflammation Through the HMGB1/NF-κB Signaling Pathway to Promote the Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells [0.03%]
姜黄素通过HMGB1/NF-κB信号通路抑制脂多糖诱导的炎症以促进骨髓间充质干细胞成骨分化
Jimei Zhang,Donggang Mou,Ling Zhu et al.
Jimei Zhang et al.
Curcumin has strong anti-inflammatory properties and promotes the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). The aim of this study was to explore the role and potential molecular mechanism of curcumin i...
Phytochemical Screening and Computational Insights into VP26 Inhibitors for Mitigating White Spot Syndrome Virus in Shrimp Aquaculture [0.03%]
基于植物化学筛选和计算研究的VP26抑制剂抗对虾养殖中白斑病毒的研究
S J Md Ashiq,A C Snekha,T Muthu Kumar et al.
S J Md Ashiq et al.
White spot syndrome disease (WSSD) is a contagious disease caused by white spot syndrome virus (WSSV) in shrimp aquaculture. Given its high degree of contagiousness, controlling its rapid spread has proven to be challenging, causing signifi...
pFastBac4x: A Novel Vector for the Simultaneous Expression of Four Proteins-Expression and Purification of a G-Protein Complex as a Case Study [0.03%]
pFastBac4x：一种同时表达四种蛋白质的新载体——G蛋白复合物的表达和纯化为例
Ioanna Ramou,Steven Janvier,Pieter Claes et al.
Ioanna Ramou et al.
Baculovirus-mediated expression in insect cells has become one of the most widely used expression systems for the production of eukaryotic proteins. Since the initial discovery that baculoviruses can be employed for the heterologous express...
Keli Xu,Minlin Yang,Lihong Guan et al.
Keli Xu et al.
Niemann-Pick disease (NPD) is a rare autosomal recessive neurodegenerative disease characterized by hepatosplenomegaly, neuropathy, and a significantly shortened lifespan. Lipid metabolism disorder is the main pathological feature of NPD. C...
Dingkun Pill-Mediated TGF-β1/Smad2 Pathway Effects on Granulosa Cell Proliferation and Apoptosis [0.03%]
调气养血汤调控颗粒细胞TGF-β1/smad2信号通路对颗粒细胞增殖及凋亡的影响
Lan Chen,Xiaojing Yan,Yuanpei Lian et al.
Lan Chen et al.
To investigate influences of Dingkun Pill on granulosa cell proliferation and apoptosis (P&A) in polycystic ovary syndrome (PCOS) mice and its association with the TGF-β1/Smad2 signaling pathway (SPW) activity. Forty-eight female SD mice w...
The Role of Calcium Ions in Restoring Lipase Activity of Recombinant Human Lipoprotein Lipase Expressed in Bacteria [0.03%]
钙离子在重组人载脂蛋白脂酶细菌表达复性中的作用研究
Chong Lee Ng,Theam Soon Lim,Yee Siew Choong
Chong Lee Ng
Lipoprotein lipase (LPL) is a blood vessel lipase that regulates and removes plasma lipoprotein triglycerides from blood circulation. It is important in the control of hypertriglyceridemia. LPL dysregulation can lead to hypertriglyceridemia...
Multi-omics Analysis Revealed the Diagnostic and Therapeutic Value of Immunogenic Cell Death-derived SCN5A in Hepatocellular Carcinoma [0.03%]
多组学分析揭示了免疫性细胞死亡衍生的SCN5A在肝细胞癌诊断和治疗中的价值
Zicheng Liang,Wei Tan,Xiayi Fang et al.
Zicheng Liang et al.
This study explores the diagnostic and therapeutic potential of SCN5A, an immunogenic cell death (ICD)-related gene, in hepatocellular carcinoma (HCC). Integrated analysis of four databases identified 62 ICD-associated genes (ICDGs), with S...
Interplay of Surfactant Protein A and Tumor Necrosis Factor α in Lung and Intestinal Tissues of Rats with Severe Pneumonia [0.03%]
严重肺炎大鼠肺和肠组织中肺表面活性物质蛋白A与肿瘤坏死因子α的互作关系
Jin Zhang,Yangjia Deng,Guansheng Li et al.
Jin Zhang et al.
The evaluation of disease progression in rats with severe pneumonia and septic shock relies on the expression of indicators in the lung, intestinal microenvironment, and serum. A rat model was created for this purpose and the serum samples ...