Molecular Mechanism of Compound Glycyrrhizin in Kainic Acid-Induced Epilepsy in Rat Model [0.03%]
甘草合剂治疗KA致痫大鼠的分子机制研究
Li Shang,Hui Guo,Deshan Gong
Li Shang
This study explores the effects of compound glycyrrhizin (GL) on seizures in the rat model and its potential molecular mechanisms. Eighty male, healthy, and clean-graded Sprague Dawley (SD) rats, aged 1 month, were used in this study. Of th...
Molecular Characterization and Investigating the Potential of Georgenia Satyanarayanai as an Effective Agent in Pesticide Biodegradation Pathways [0.03%]
乔治纳利亚卫星亚种农药降解分子机理研究
Muhammad Naveed,Maida Salah Ud Din,Tariq Aziz et al.
Muhammad Naveed et al.
The persistent nature and toxic effects of pesticides are commonly employed in agriculture to increase crop yields and fight pests, which poses a serious risk to the environment. These chemical compounds, designed to target specific pests, ...
Extracellular Expression and Diagnostic Potential of Dengue Virus Type 3 E Protein Domain III Through Codon Optimization in Komagataella phaffii [0.03%]
基于密码子优化的毕赤酵母表达登革病毒3型E蛋白Ⅲ域及诊断应用潜力研究
Camila Marques de Simone,Maria Carolina Yi Lin Lee,Yasmin Mayra Bispo et al.
Camila Marques de Simone et al.
Dengue is a mosquito-borne viral disease caused by the dengue virus (DENV), which affects millions worldwide. The envelope (E) protein, particularly domain III (EDIII), plays a critical role in viral entry and is a major target for diagnost...
DAPK3-Ablation Regulates the AMPK/mTOR-GPX4 Signaling Pathway to Affect Biological Functions of Staphylococcus aureus-Treated Bone Marrow Mesenchymal Stem Cells and Potentially Ameliorate Osteomyelitis [0.03%]
DAPK3敲除通过调节AMPK/mTOR-GPX4信号通路影响金黄色葡萄球菌诱导的骨髓间充质干细胞生物学功能并可能改善骨髓炎
Nannan Kou,Runyao Zhang,Feifei Liu et al.
Nannan Kou et al.
Staphylococcus aureus (SA)-caused osteomyelitis (OM) is inflammation-related refractory disease that seriously degrades the life quality of human beings. Unfortunately, up until now, the molecular mechanisms of OM progression have not been ...
Recombinase Polymerase Amplification (RPA) as an Isothermal Molecular-Point of Care Test (IM-POCT) for Rapid Identification of P. aeruginosa Among Patients with Respiratory Infection [0.03%]
铜绿假单胞菌呼吸道感染者快检用重组酶聚合酶扩增（RPA）等温分子即时检测（IM-POCT）
Reza Azizian,Erfaneh Jafari,Babak Pourakabri et al.
Reza Azizian et al.
Acute Respiratory Infections (ARIs) are a leading cause of pediatric mortality, with Pseudomonas aeruginosa as a key pathogen. This study evaluated Recombinase Polymerase Amplification (RPA)-ELISA for rapid detection of P. aeruginosa in res...
A New Small and Resilient Nucleic Acid-Binding Protein from Nanoarchaeum equitans [0.03%]
纳米古菌中的新型小而耐热的核酸结合蛋白
Klaudia Marlicka,Katarzyna M Serafin,Julia A Sobieska et al.
Klaudia Marlicka et al.
Nucleic acid-binding proteins (NBPs) are essential biomolecules in all organisms. They play an important role in gene regulation and expression in cells. One type of these proteins is DNA- and RNA-binding proteins, known as DRBPs. In recent...
Transforming Hemophilia Management: Lessons from Gene Therapy Clinical Trials [0.03%]
转化性血友病管理：基因疗法临床试验的启示
Md Sadique Hussain,Mudasir Maqbool,Mohammed M Arab et al.
Md Sadique Hussain et al.
Gene therapy signifies a transformative revolution in hemophilia care, providing the possibility for sustained endogenous synthesis of coagulation factors and limiting the need for external factor supplementation. Preliminary experiments in...
Overcoming Multidrug Resistance in E. coli and Salmonella Isolates from Nile Tilapia: Synergistic Effects of Novel Antibiotic Combinations [0.03%]
克服尼罗罗非鱼中大肠杆菌和沙门氏菌多重耐药性：新型抗生素组合的协同作用
Laiba Shafique,Muhammad Farhan Khan,Shakeela Parveen et al.
Laiba Shafique et al.
Escherichia coli and Salmonella are significant foodborne zoonotic pathogens, causing serious human illness. The rising global prevalence of antimicrobial resistance (AMR) in these species exacerbates their public health risk, complicating ...
Uncovering the Unique Epitopes: Validation of In-Silico Synthesized Tetravalent Dengue Vaccine (dvac) Through Cloning, Expression, and Immunogenic Analysis [0.03%]
基于计算合成的四价登革疫苗(dvac)的克隆、表达及免疫原性分析研究
Sitara Nasar,Saima Iftikhar,Muhammad Shahid Nadeem
Sitara Nasar
Dengue is an arthropod borne viral illness which infects millions of people each year. Despite the huge global losses, an effective medication is still unavailable against the disease. For vaccine development, reverse vaccinology approach i...
Shaping the Plant Specialized Metabolites Through Modern Breeding Technique [0.03%]
通过现代育种技术塑造植物次级代谢产物
Sayanti Mandal
Sayanti Mandal
Plant specialized metabolites (PSMs) have significantly diversified throughout evolutionary history and are regarded as crucial contributors to intricate interactions between plants and the changing environment. The chemical nature of these...