Anti-chikungunya Activity of a Cinnamic Acid Derivative: An In Vitro and In Silico Study [0.03%]
茋类化合物的抗奇昆古尼亚热活性：体外和分子对接研究
Kalichamy Alagarasu,Dwidhesh Kharikar,Diya Roy et al.
Kalichamy Alagarasu et al.
Chikungunya virus (CHIKV) is an arthropod-borne virus that causes debilitating joint pain and fever with limited treatment options. Cinnamic acid, known for its broad-spectrum biological activities, and its derivatives were evaluated for th...
Development and Validation of Real-Time Allele-Specific PCR-Based Genotyping of the rs1042713 Variant in the ADRB2 Gene and Its Correlation with Salbutamol Response [0.03%]
ADRB2基因rs1042713多态性实时等位基因特异性分型方法的建立及与临床沙丁胺醇舒张气道效应的相关性分析
Dilla Jose,N S Vincent
Dilla Jose
Asthma is a prevalent chronic respiratory disease influenced by genetic and environmental factors. The beta-2 adrenergic receptor (ADRB2) gene, located on chromosome 5q31-q32, plays a crucial role in bronchodilation by regulating airway smo...
Expression of Dual Cry1Ab and Cry1Ac Genes Under Regulation of MPI Promoter Enhances Resistance to Tomato Fruit Borer (Helicoverpa armigera) in Tomato [0.03%]
MPI启动子调控的双价Cry1Ab和Cry1Ac基因表达可提高番茄对棉铃虫的抗性
Khadijeh Abbaszadeh,Reza Shirzadian-Khorramabad,Mohammad-Mehdi Sohani et al.
Khadijeh Abbaszadeh et al.
Genetic engineering provides the possibility of expressing pest-resistant genes in transgenic plants. The pyramiding gene in plants is suggested to be a sustainable method for addressing pest resistance. To enhance resistance to tomato frui...
Inhibition of GPR75 Alleviates Lipid Metabolism by Activating the AMPK-SIRT1 Signaling Pathway In Vitro and In Vivo [0.03%]
体内体外通过激活AMPK-SIRT1信号通路缓解脂质代谢紊乱的新机制：GPR75的抑制作用
Junyu Wang,Guishun Sun,Shiwen Li et al.
Junyu Wang et al.
The pathogenesis of non-alcoholic fatty liver disease (NAFLD) is primarily driven by excessive lipid accumulation and metabolic dysregulation, necessitating a comprehensive investigation into the underlying mechanisms. This study employed a...
Characterization of the YCjN ABC Transporter in Escherichia coli: Role in Maltose and Ethidium Bromide Transport [0.03%]
大肠杆菌YCjN ABC转运蛋白的表征：参与麦芽糖和溴化乙锭转运的作用
Yanhong Wang,Beibei Xu,Amro Abdelazez et al.
Yanhong Wang et al.
This study investigated the functional role of the ycjN gene in Escherichia coli, hypothesizing that its encoded protein, YcjN, functions as a carbohydrate transporter. Bioinformatics analysis confirmed YcjN as a solute-binding protein (SBP...
Nanoemulsion-Based Tea Tree Oil: A New Frontier in Enhancing Clotrimazole Antifungal Activity [0.03%]
基于纳米乳化技术的茶树油：增强克霉唑抗真菌活性的新前景
Fatemeh Khorsand,Seyed Jamal Hashemi,Shahram Mahmoudi et al.
Fatemeh Khorsand et al.
Clotrimazole is widely used to treat fungal diseases, but it should be applied topically for several weeks to be effective. Previous studies have shown that nanoemulsions can enhance the topical activity of various active ingredients. This ...
Prognostic and Immunologic Characteristics of Head and Neck Squamous Cell Carcinoma Based on Disulfidptosis-Related lncRNAs [0.03%]
基于二硫键依赖型蛋白酶相关长链非编码RNA的头颈鳞状细胞癌预后及免疫学特征分析
Sai Liang,Xuan Yang,Ji Wang et al.
Sai Liang et al.
Disulfidptosis is a new and unique mode of cell death in malignant tumors that plays an important role in tumorigenesis and development. This study aimed to investigate the prognostic value of disulfideptosis-related lncRNAs (DRLs) in head ...
Different Distribution of Carotenoid Content in Periderm-Phloem-Xylem of Red Carrot Taproots [0.03%]
红 carrots 主根周皮-韧皮-木质部类胡萝卜素分布差异分析
Xue-Feng Peng,Ya-Hui Wang,Rong-Rong Zhang et al.
Xue-Feng Peng et al.
The color of carrot taproots is mainly determined by the types and contents of carotenoids and anthocyanins. Consistency in taproot color from the outside to the inside is an important indicator of carrot quality. However, most carrot culti...
Characterization of a Phage Display-Selected scFv Against Neuropilin 1 (NRP1) Isolated from a Naïve Human Library [0.03%]
从 naive 型人抗体文库中筛选的神经纤毛蛋白-1(NRP1)结合单链抗体的鉴定与表征
Khadijeh Farrokhi,Fatemeh Nasiri,Pouya Safarzadeh Kozani et al.
Khadijeh Farrokhi et al.
Immune checkpoint inhibitors are established therapeutics for solid tumors. This study isolated a single-chain fragment variable (scFv) targeting neuropilin 1 (NRP1), a promising therapeutic target. A naïve human scFv phage display library...
Significance of a Novel Angiogenesis-Related Biomarker Neuropilin-1 in Keloids [0.03%]
神经纤毛蛋白-1在增生性瘢痕和瘢痕疙瘩中表达的意义研究是一项新型的血管生成标志物
Ming-Yuan Jin,Xiao-Ying Lin,Yong Wang et al.
Ming-Yuan Jin et al.
Keloids are a severe type of pathological scars caused by excessive connective tissue hyperplasia after skin injury. Uncontrolled angiogenesis during wound healing can contribute to keloid formation, highlighting the importance of angiogene...