Inhibition of miR-20a-5p Suppresses Epithelial-Mesenchymal Transition of Colorectal Cancer Cells Through GJA1 [0.03%]
抑制miR-20a-5p通过GJA1抑制结直肠癌细胞的上皮间质转化
Lu Zhang,Jun-Bin Wang,Zhen-Yuan Gao et al.
Lu Zhang et al.
This study was designed to clarify the role of GJA1 in colorectal cancer. qPCR was adopted to detect the GJA1 and miR-20a-5p expression levels in tumor tissues and cells; and EdU, Transwell assay, Scratch test to examine the migration, inva...
Network Pharmacology and Molecular Docking-Based Screening of Immunotherapeutic Targets for HuaChanSu Against Breast Cancer [0.03%]
基于网络药理学和分子对接的华蟾素抗乳腺癌免疫治疗靶点筛选
Yujun Tang,Jie Luo,Liuqing Qin et al.
Yujun Tang et al.
Breast cancer has emerged as the primary cause of mortality stemming from malignancies among women. HuaChanSu has demonstrated efficacy in suppressing the progression of various malignancies. However, the specific immune targets and pathway...
Generation of Ext1 Gene-Edited Mice Model Via Dual sgRNAs/Cas9 System and Phenotypic Analyses [0.03%]
基于双sgRNAs/Cas9系统生成Ext1基因编辑小鼠模型及表型分析
Lan Zhou,Xin Li,Zihan Ji et al.
Lan Zhou et al.
Hereditary multiple exostoses (HME) is an autosomal dominant skeletal disease. Genetic linkage analyses have identified that mutations in the exostosin glycosyltransferase (EXT)1 and EXT2 genes are linked to HME pathogenesis, with EXT1 muta...
Integrative Investigation of Flavonoids Targeting YBX1 Protein-Protein Interaction Network in Breast Cancer: From Computational Analysis to Experimental Validation [0.03%]
计算与实验相结合的黄酮类化合物靶向乳腺癌YBX1蛋白质相互作用网络研究
Presanna Kumar Sreelekshmi,Suresh Kumar Pooja,Niranjan Vidya et al.
Presanna Kumar Sreelekshmi et al.
Y-box-binding protein 1 (YBX1) is a multifunctional oncoprotein with its nuclear localization contributing to chemo-resistance in breast cancer. Through its interactions with various proteins and lncRNAs, YBX1 promotes cancer cell migration...
The Relationship Between BigET-1 and Cardiac Remodeling in Patients with Hypertrophic Obstructive Cardiomyopathy [0.03%]
大ET-1与肥厚性心肌病患者心脏重塑的关系
Hua Li,Xiao Cao,Hao Wu et al.
Hua Li et al.
To explore the relationship between BigET-1 and cardiac remodeling in hypertrophic obstructive cardiomyopathy (HOCM). A retrospective analysis was conducted on the data of 150 HOCM patients in a hospital from September 2021 to August 2023. ...
N6-Methyladenosine Modification of PERP by RBM15 Enhances the Tumorigenesis of Lung Adenocarcinoma via p53 Signaling Pathway [0.03%]
RBM15介导的PERP甲基化通过p53信号通路促进肺癌的发生发展
Ruiying Li,Xiaochuang Xia,Wenping Chen et al.
Ruiying Li et al.
The promotive effect of P53 apoptosis effector related to PMP-22 (PERP) on lung adenocarcinoma (LUAD) has been confirmed. However, the N6-methyladenosine (m6A) modification of PERP to regulate LUAD progression have not been revealed. Bioinf...
Intermittent Hypoxia Impairs Cognitive Function and Promotes Mitophagy and Lysophagy in Obstructive Sleep Apnea-Hypopnea Syndrome Rat Model [0.03%]
间歇缺氧损害认知功能并促进阻塞性睡眠呼吸暂停低通气综合征大鼠模型线粒体自噬和溶酶体自噬
Jizu Ling,BoWen Li,XinHui Yuan et al.
Jizu Ling et al.
Autophagy regulates intermittent hypoxia (IH)-induced obstructive sleep apnea-hypopnea syndrome (OSAHS). We investigated the effects of IH and its withdrawal on cognitive function, autophagy, and lysophagy in OSAHS. An OSAHS rat model was e...
Astragaloside IV Inhibits Lung Injury and Fibrosis Induced by PM2.5 by Targeting RUNX1 Through miR-362-3p [0.03%]
黄芪苷IV通过miR-362-3p/RUNX1轴抑制PM2.5诱导的肺损伤与纤维化
Hao Tian,Yan Zhang,Wei Li et al.
Hao Tian et al.
To discover the molecular mechanism of Astragaloside IV (AS IV) in PM2.5-induced lung injury and pulmonary fibrosis (PF). A lung injury rat model was induced by PM2.5 and injected intraperitoneally with AS IV. Lungs were harvested to evalua...
Qiang Jin Mixture Promotes Osteogenic Differentiation of MC3T3-E1 Cells via BMP2/Smads Pathway and its Network Pharmacology Study [0.03%]
强筋合剂通过BMP2/Smads信号通路促进MC3T3-E1细胞成骨分化的网络药理学研究
Weiyue Gong,Yao Zhu,Limin Wang
Weiyue Gong
The study aimed to explore the potential of QiangJin mixture (QJM), a Chinese herbal compound prescription, in regulating MC3T3-E1 cell differentiation and to analyze the ingredients and therapeutic targets of QJM against osteoporosis based...
Machine Learning Approaches for Microorganism Identification, Virulence Assessment, and Antimicrobial Susceptibility Evaluation Using DNA Sequencing Methods: A Systematic Review [0.03%]
基于DNA测序方法的机器学习技术在微生物鉴定、毒力评估和抗微生物药物敏感性评价中的应用：系统综述
Abel Onolunosen Abhadionmhen,Caroline Ngozi Asogwa,Modesta Ero Ezema et al.
Abel Onolunosen Abhadionmhen et al.
Microbial infections pose a substantial global health challenge, particularly impacting immunocompromised individuals and exacerbating the issue of antimicrobial resistance (AMR). High virulence of pathogens can lead to severe infections an...