In Silico Structural Insights into a Glucanase from Clostridium perfringens and Prediction of Structural Stability Improvement Through Hydrophobic Interaction Network and Aromatic Interaction [0.03%]
从头算结构见解：产气荚膜梭菌半纤维素酶及疏水和芳香作用网络预测结构稳定性改善
Nima Ghahremani Nezhad,Azadeh Eskandari,Oluwaloni Folusho Omotayo et al.
Nima Ghahremani Nezhad et al.
Glucanases are widely applied in industrial applications such as brewing, biomass conversion, food, and animal feed. Glucanases catalyze the hydrolysis of glucan to produce the sugar hemiacetal through hydrolytic cleavage of glycosidic bond...
Metal-Coordinated Histidine-Functionalized Redox-Responsive Polyethyleneimine as a Smart Gene Delivery Vector [0.03%]
一种用于智能基因传递载体的金属配位组氨酸功能化氧化还原响应性聚乙烯亚胺
Makkieh Jahanpeimay Sabet,Akbar Hasanzadeh,Amirhossein Vahabi et al.
Makkieh Jahanpeimay Sabet et al.
Despite significant advancements in gene delivery and CRISPR technology, several challenges remain. Chief among these are overcoming serum inhibition and achieving high transfection efficiency with minimal cytotoxicity. To address these iss...
CRISPR/Cas9 System as a Promising Therapy in Thalassemia and Sickle Cell Disease: A Systematic Review of Clinical Trials [0.03%]
CRISPR/Cas9系统在地中海贫血和镰刀型细胞疾病中的临床试验系统性回顾：有前景的治疗方式
Rehab Ahmed,Wafa N Alghamdi,Fetun R Alharbi et al.
Rehab Ahmed et al.
Clustered, regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein (Cas) system is a new gene editing tool that represents a revolution in gene therapy. This study aimed to review the clinical trials conducted to ...
A Bibliometric Analysis on Multi-epitope Vaccine Development Against SARS-CoV-2: Current Status, Development, and Future Directions [0.03%]
针对SARS-CoV-2的多抗原疫苗开发的文献计量分析：现状、进展与未来方向
Kanwal Khalid,Fiaz Ahmad,Ayaz Anwar et al.
Kanwal Khalid et al.
The etiological agent for the coronavirus disease 2019 (COVID-19), the SARS-CoV-2, caused a global pandemic. Although mRNA, viral-vectored, DNA, and recombinant protein vaccine candidates were effective against the SARS-CoV-2 Wuhan strain, ...
Molecular Evolution of Paralogous Cold Shock Proteins in E. coli: A Study of Asymmetric Divergence and Protein Functional Networks [0.03%]
大肠杆菌正交冷休克蛋白的分子进化：非对称发散和蛋白质功能网络研究
Alankar Roy,Sujay Ray
Alankar Roy
Nine homologous Cold Shock Proteins (Csps) have been recognized in the E.coli Cold Shock Domain gene family. These Csps function as RNA chaperones. This study aims to establish the evolutionary relationships among these genes by identifying...
Integrative Analysis of the Role of MRPL21 in Human Pan-Cancer and Its Relationship with the Progression of Lung Adenocarcinoma [0.03%]
MRPL21在人类泛癌中的作用的集成分析及其与肺腺癌进展的关系研究
Qi Xu,Jiale Wang,Jing Wang et al.
Qi Xu et al.
Mitochondrial ribosomal protein L21 (MRPL21) is essential for normal cell function and may play a significant role in cancer development. In this study, we performed a comprehensive pan-cancer analysis to explore MRPL21's function across di...
Identification and Validation of Alkaliptosis Resistance-Associated Genes in Prostate Cancer Via Transcriptome Sequencing and Prediction of Biochemical Recurrence [0.03%]
通过转录组测序鉴定和验证前列腺癌中与碱液耐受性相关的基因并预测生化复发风险
Xiaodong Song,Yu Zhang,Tiewen Li et al.
Xiaodong Song et al.
Androgen deprivation therapy (ADT) is the primary treatment strategy for prostate cancer. However, despite an initially favorable response, tumors inevitably progress to castration-resistant prostate cancer (CRPC). Therefore, the exploratio...
R2R3 MYB Transcription Factors Involved in Flower Petal Pigmentation via Regulating Anthocyanin Synthesis in Rhododendron simsii [0.03%]
杜鹃花花瓣颜色形成中一类调控花青素合成的R2R3-MYB转录因子
Shao Changsheng,Zheng Huijun,Cai Fangfang et al.
Shao Changsheng et al.
Azaleas (Rhododendron simsii) are popular ornamental woody plants known for their bright colors; however, very limited studies have been reported on the process of flower petal pigmentation. In this study, we found significant differences i...
Development of a Molecular Beacon-Based Genosensor for Detection of Human Rotavirus A [0.03%]
人轮状病毒A型分子信标基因传感器的研制
Pooja Rani Kuri,Pranab Goswami
Pooja Rani Kuri
The rotavirus-led fatal infantile gastroenteritis in the globe demands a portable, specific, and low-cost diagnostic tool for its timely detection and effective surveillance in a mass population. Consequently, the design and development of ...
Identification and Evaluation of Natural Compounds as Potential Inhibitors of NS2B-NS3 Zika Virus Protease: A Computational Approach [0.03%]
基于计算的天然化合物作为潜在抑制剂防控寨卡病毒NS2B-NS3蛋白酶的识别与评估
Nada Anede,Mebarka Ouassaf,Kannan R R Rengasamy et al.
Nada Anede et al.
The Zika virus (ZIKV), an arbovirus within the Flavivirus genus, is associated with severe neurological complications, including Guillain-Barré syndrome in affected individuals and microcephaly in infants born to infected mothers. With no ...