DSCC1 Identified as Promising Tumor Biomarker and Potential Therapeutic Target Through Comprehensive Multi-omics Analysis and Experimental Validation [0.03%]
通过全面的多组学分析和实验验证识别DSCC1为有前景的肿瘤生物标志物及潜在治疗靶点
Wei Cheng,Peng Lin
Wei Cheng
As a component of the alternative replication factor C (RFC) complex, DSCC1 plays a significant role in cancer progression due to its aberrant expression. However, the potential function of DSCC1 in a pan-cancer context remains unclear. In ...
Elucidation of Bacterial-Mediated Hesperidin Transformation, Structural Evaluation, and Computational Drug Targeting against Helicobacter pylori [0.03%]
柚皮素的细菌转化机理研究、结构评估和针对幽门螺旋杆菌的计算药物筛选目标
Muhammad Naveed,Sara Khan,Tariq Aziz et al.
Muhammad Naveed et al.
Biotransformation, a dynamic process conducted by microorganisms, holds promise in modifying natural compounds for enhanced therapeutic potential. In this study, we leverage bacterial systems to catalyze the transformation of hesperidin, ob...
Non-targeted Metabolomics Reveals the Potential Role of MFSD8 in Metabolism in Human Endothelial Cells [0.03%]
非靶向代谢组学揭示MFSD8在人血管内皮细胞代谢中的潜在作用
Qin Xiang,Yongjun Chen,Xu Cheng et al.
Qin Xiang et al.
The major facilitator superfamily domain containing 8 (MFSD8) belongs to an orphan transporter protein expressed in a wide range of tissues. Nevertheless, the specific role of MFSD8 in human health and disease remains unknown. This study ai...
Caffeine Sodium Benzoate Promotes Endothelial Dysfunction of Human Umbilical Vein Endothelial Cells by Promoting M1 Macrophage Polarization [0.03%]
咖啡因苯甲酸钠通过促进M1型巨噬细胞极化导致人脐静脉内皮细胞功能障碍
Tianwei Yu,Jiale Wei,Lili Tian et al.
Tianwei Yu et al.
Our previous study uncovered that long-term abuse of caffeine sodium benzoate (CSB) could lead to dysfunction in human umbilical vein endothelial cells (HUVECs). However, the mechanism by which CSB induced endothelial dysfunction remains la...
Analyzing the Molecular Signature Genes and Pathways of Dengue Fever, Dengue Hemorrhagic Fever and Dengue Shock Syndrome Caused by Dengue Virus in India [0.03%]
印度登革热病毒所致的登革热，登革出血热和登革休克综合征的分子标志基因及信号通路分析
Debojyati Datta,Semanti Ghosh
Debojyati Datta
Dengue fever, dengue hemorrhagic dengue fever and dengue shock syndrome were caused by Dengue mosquito bites. Common signs such as fever and headache, are connected to distinctive medical disorders. From the previous and ongoing studies, it...
An Engineered SARS-CoV-2 S1 Glycoprotein Produced in Pichia pastoris as a Candidate Vaccine Antigen [0.03%]
作为疫苗抗原候选的在Pichia pastoris中生产的工程化SARS-CoV-2 S1糖蛋白
Sanaz Majidi,Khosrow Aghaiypour Kolyani,Meisam Akrami et al.
Sanaz Majidi et al.
Since December 2019, the SARS-CoV-2 virus has caused the global COVID-19 pandemic. Antiviral and anti-inflammatory treatments have had limited success, positioning vaccine development as a key strategy for public health. This study construc...
Unlocking the Synergistic Potential and Efficacy of Biosurfactant-Silver Nanoparticle for Enhanced Antimicrobial Activities [0.03%]
生物表面活性剂-银纳米粒子的协同潜力及其增强的抗菌活性研究
Babita Thakur,Sukhminderjit Kaur
Babita Thakur
Microorganisms can produce various amphiphilic compounds known as biosurfactants, with diverse applications in distinct industries. This study was focused on the biosurfactant production by Limosilactobacillus fermentum HBUAS62516 for the s...
The Role of Yes-Associated Protein in Autophagy and Tumor Progression in Gastric Cancer [0.03%]
胃癌中Yes相关蛋白在自噬及肿瘤进展中的作用研究
Yanzhao Jin,Hua Cheng,Xiaoyun Hu et al.
Yanzhao Jin et al.
The Yes-associated protein (YAP) is a key regulator in the pathogenesis of gastric cancer (GC), yet its role in modulating autophagy remains unclear. This study investigated the effects of YAP modulation on autophagy and tumor progression u...
Identification of Glycolysis-Related Signature and Molecular Subtypes in Child Sepsis Through Machine Learning and Consensus Clustering: Implications for Diagnosis and Therapeutics [0.03%]
通过机器学习和共识聚类识别儿童脓毒症中与糖酵解相关的特征和分子亚型：对诊断和治疗的启示
Chenyu Ma,Jianlong Wang
Chenyu Ma
Pediatric sepsis remains one of the leading causes of mortality in children worldwide. Despite advances in medical care, the prognosis of pediatric sepsis is still poor, necessitating the need for more precise diagnostic and therapeutic str...
Exploring Ketones in Chrysopogon zizanioides: A Computational Molecular Dynamic Approach to c-Met Modulation [0.03%]
探討香附子中的酮類化合物：使用計算分子動力學方法調節c-Met蛋白質
Somayeh Sabaghan,Rashi Srivastava,Pardeep Yadav et al.
Somayeh Sabaghan et al.
Glioblastoma demands the designing of potential drugs as there is no specific treatment available. In this study, we employed computational screening techniques to identify potential modulators of the c-Met receptor from a library of 273 Ch...