Genetic Insights Into the Central Role of Serine β-Lactamase-Like Protein in Lipid Metabolism, Metabolic Syndrome, and Chronic Kidney Disease [0.03%]
遗传学视角下丝氨酸β-内酰胺酶样蛋白在脂质代谢、代谢综合征和慢性肾脏病中心作用的新认识
Han Xu,Mengxiao Zou,Yichun Cheng et al.
Han Xu et al.
Serine β-lactamase-like protein (LACTB), a mitochondrial protease, has incompletely characterized roles in metabolic pathways. We employed Mendelian randomization to investigate LACTB's causal relationships with lipid metabolism, metabolic...
Polyunsaturated Fatty Acids in Celiac Disease: Intake Patterns While on Gluten-Free Diet [0.03%]
无麸质饮食状态下摄入多不饱和脂肪酸与乳糜泻的关系
Valentina Rosas,Juan Rodríguez,Magdalena Araya et al.
Valentina Rosas et al.
Celiac disease (CD), an autoimmune disorder triggered by gliadin, is treated with a strict gluten-free diet. While omega-3 intake is known to reduce inflammation in other autoimmune diseases, its role in CD remains unclear due to limited da...
Impact of CYP2C19 Genotype Variants on PCSK9 Inhibitor Efficacy in Lipid-Lowering Among Patients With Symptomatic Intracranial Atherosclerotic Stenosis [0.03%]
CYP2C19基因多态性对有症状颅内动脉狭窄患者使用PCSK9抑制剂降脂疗效的影响
Chao Zhao,Nuan Wang,Di Shi et al.
Chao Zhao et al.
Ischemic stroke is frequently associated with symptomatic intracranial atherosclerotic stenosis (sICAS), is a leading cause of global disability and mortality. Current guidelines recommend dual antiplatelet and intensive statin therapies. P...
A Novel Hypothesis for the Protective Rise in Cholesterol Sulfate Against Lipid Metabolic Disorders [0.03%]
胆固醇硫酸盐保护作用的新假说对抗脂质代谢紊乱的作用机制
Xiaoyue Li,Chengcheng Wang,Yuming Wang et al.
Xiaoyue Li et al.
As a cholesterol metabolite, cholesterol sulfate (CS) is widely distributed in the human body, and its role as a regulatory factor has been continuously explored from the 1980s to the present day. However, changes in CS in metabolic disorde...
Network Pharmacology Insights Into Statin-Induced Coenzyme Q10 Deficiency: Lipid Metabolic Crosstalk, TNF-MAPK Signaling, and Muscle Toxicity [0.03%]
他汀类药物诱导辅酶Q₁缺乏的网络药理学见解：脂质代谢相互作用、TNF-MAPK信号和肌肉毒性
Nila Ganamurali,Sarvesh Sabarathinam
Nila Ganamurali
This in silico network-pharmacology investigation delineates the molecular interplay linking statin-induced Coenzyme Q10 (CoQ10) deficiency to statin-associated muscle symptoms (SAMS). GeneCards-derived targets related to SAMS, CoQ10 defici...
Exploring Key Lipid Molecules of Primary Dysmenorrhea for Elucidating the Biological Effects of Danggui Shaoyao San Using UPLC-Q-TOF-MS-Based Lipidomics [0.03%]
基于UPLC-Q-TOF-MS脂质组学探讨当归芍药散治疗原发性痛经的关键脂质分子及生物学效应
Na Li,Yuxin Dong,Shengnan Zhao et al.
Na Li et al.
Primary dysmenorrhea (PD) has always been a significant clinical challenge affecting women's health. Traditional Chinese medicine (TCM) has attracted considerable research interest owing to its advantages of multiple target and multiple pat...
Guggulsterone, a Classical Lipid-Lowering Phytosteroidal FXR Antagonist, as a Modulator of Lipid Signaling and Metabolic Reprogramming in Cancer [0.03%]
甘草亭，一种经典的降低血脂的植物固醇类FXR拮抗剂，在癌症中的脂质信号传导和代谢重组调节作用
Nila Ganamurali,Mohanapriya Devarajan,Sarvesh Sabarathinam
Nila Ganamurali
Dysregulated lipid metabolism fuels cancer progression through enhanced lipogenesis, cholesterol synthesis, and fatty acid oxidation. Herbal bioactives provide multi-targeted molecular interventions capable of restoring lipid homeostasis wh...
Review
Lipids. 2025 Dec 1. DOI:10.1002/lipd.70030 2025
Patient Characteristics Across Lipoprotein(a) Levels: Insights From a Retrospective Study [0.03%]
基于回顾性研究的Lp(a)不同水平患者的特征分析
Clara M Howell,Liv Hald Nyhave,Bent Raungaard et al.
Clara M Howell et al.
Elevated plasma lipoprotein(a) (Lp(a)) (> 125 nmol/L) is highly prevalent and a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) that may contribute significantly to plasma levels of low-density lipoprotein-cholesterol ...
Association Between Non-High-Density Lipoprotein Cholesterol and High-Density Lipoprotein Cholesterol Ratio With Albuminuria: A Cross-Sectional NHANES Study [0.03%]
非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值与白蛋白尿的关联：横断面NHANES研究
Meihan Chen,Shuling Fan,Xiao Huang et al.
Meihan Chen et al.
The non-high-density lipoprotein cholesterol (non-HDL-c) to high-density lipoprotein cholesterol (HDL-c) ratio (NHHR) is an emerging and valuable biomarker for cardiovascular disease risk. Nevertheless, robust evidence regarding its relatio...
Integrative Network Analysis of Antioxidant Nutrients Targeting 7-Ketocholesterol-Induced Lipotoxicity via Sterol Metabolism and Organelle Protection Pathways [0.03%]
抗氧化营养素综合网络分析靶向通过固醇代谢和细胞器保护途径的7-酮胆固醇诱导的脂毒性
Nila Ganamurali,Sarvesh Sabarathinam
Nila Ganamurali
7-Ketocholesterol (7-KC), a cytotoxic oxysterol, contributes to atherosclerosis, neurodegeneration, and metabolic disorders by promoting oxidative stress, inflammation, and dysfunction of organelles including mitochondria, peroxisomes, lyso...