Oral Delivery of Tocotrienols: Addressing Pharmacokinetic Challenges With Formulation-Based Strategies [0.03%]
托考トリ恩的口服给药：通过基于配方的方法解决药代动力学挑战
An Gie Ooi,Kah Hay Yuen,Chee Chin Chu et al.
An Gie Ooi et al.
Tocotrienols (T3), vitamin E analogues with potent antioxidant and therapeutic properties, have attracted increasing scientific interest. However, their clinical translation is hindered by poor and variable oral bioavailability. This limita...
Review
Lipids. 2026 Jun 18. DOI:10.1002/lipd.70069 2026
Very Low Cholesterol Non-Cardiovascular Risks: A Critical Appraisal and Framework for Individualized Management [0.03%]
非常低的胆固醇与非心血管疾病风险：批判性评估及个体化管理框架
Alberto Boretti
Alberto Boretti
Randomized trial evidence firmly establishes that lowering LDL-C reduces atherosclerotic cardiovascular disease. However, observational studies consistently report U-shaped cholesterol-mortality associations, raising concerns about potentia...
Review
Lipids. 2026 Jun 14. DOI:10.1002/lipd.70068 2026
Exometabolomics Reveals Metabolic Modulation Induced by Chia Oil Supplementation in Adipose Tissue Explants From Obese Mice [0.03%]
基于肥胖小鼠的体内实验的代谢组学研究揭示奇亚籽油补充对脂肪组织的诱导效应
Gilson Costa Dos Santos Jr,Agatha Assis-Ferreira,Gabrielly Muniz-Cassuce et al.
Gilson Costa Dos Santos Jr et al.
Obesity impairs adipose tissue metabolism and dietary interventions capable of modulating these alterations remain insufficiently explored. To investigate depot-specific metabolic adaptations in subcutaneous (SAT) and epididymal adipose tis...
Analysis of the Value of Combined Detection of Serum miR-302a-3p and Low Density Lipoprotein Cholesterol in the Diagnosis of Coronary Heart Disease [0.03%]
血清miR-302a-3p与低密度脂蛋白胆固醇联合检测在冠心病诊断价值分析
Rongguo Sun,Guangli Zhang,Wei Zhang et al.
Rongguo Sun et al.
The diagnosis of premature coronary heart disease (PCHD) continues to pose challenges. miR-302a-3p serves as a potential diagnostic marker. This study investigated the diagnostic value of the combination serum miR-302a-3p and LDL-C for PCHD...
Association Between C-Reactive Protein-Triglyceride Glucose Index, and the Risk of Osteoarthritis and Rheumatoid Arthritis: Results From NHANES 1999-2010 [0.03%]
C-反应蛋白-甘油三酯-葡萄糖指数与骨关节炎和类风湿关节炎风险之间的关系：1999-2010年全国健康和营养调查结果分析
Bo Hu,Zhijun Chen,Yonghua Chen et al.
Bo Hu et al.
The serum C-reactive protein-triglyceride glucose index (CTI) is a parameter integrating inflammation and insulin resistance, which are potential mechanisms for osteoarthritis (OA) or rheumatoid arthritis (RA). Our study aims to investigate...
Transcriptomic Analysis of Shared Lipid Metabolism in Chronic Hepatitis B and Non-Alcoholic Fatty Liver Disease Using Weighted Gene Expression Network Analysis [0.03%]
利用加权基因共表达网络分析研究慢性乙肝和非酒精性脂肪肝的共享脂质代谢转录组学特征
Lihuan Wang
Lihuan Wang
Chronic hepatitis B (CHB) and non-alcoholic fatty liver disease (NAFLD) frequently coexist, and lipid metabolic dysregulation may represent a shared biological feature between these conditions. However, the molecular mechanisms linking thes...
Lipid-Soluble Signaling Molecular Model Predicts Prognosis and Immunotherapy Response in Gastric Cancer [0.03%]
脂溶性信号分子模型预测胃癌的预后和免疫治疗反应
Wenwen Zhu,Yanna Yu
Wenwen Zhu
Lipid-soluble signaling molecule-related genes (LSMRGs) are critical in various tumors, but their role in gastric cancer (GC) prognosis and therapy remains unclear. Using transcriptomic data, this study analyzed LSMRG expression patterns, m...
Efficacy of Vitamin E on Lipid Profile in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A Systematic Review and Meta-Analysis [0.03%]
维生素E对代谢功能异常相关肝脂质沉积病(MASLD)患者血脂谱影响的系统评价和 meta 分析
Mehdi Karimi,Maryam Abidi,Ayda Aghaei et al.
Mehdi Karimi et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with dyslipidemia and overweight. Vitamin E has been suggested to improve lipid metabolism, but clinical evidence in MASLD remains inconsistent. This meta-analys...
Review
Lipids. 2026 May 6. DOI:10.1002/lipd.70042 2026
Hepatic Lipids as Molecular Targets in Obesity-Associated Insulin Resistance in Rodent Models: A Systematic Review and Meta-Analysis [0.03%]
基于啮齿类动物模型的肥胖相关性胰岛素抵抗肝脂分子靶点的系统评价和meta分析研究
Rogelio I Servin-Uribe,Jara Pérez-Jiménez,Eduardo Castaño Tostado et al.
Rogelio I Servin-Uribe et al.
Obesity induced by a high-calorie diet (HCD) results in the accumulation of ectopic fat in tissues not typically associated with lipid storage. This accumulation can cause lipotoxicity, a type of cellular stress triggered by the accumulatio...
Melatonin Promotes Improvement in Serum Lipid Levels and Liver Histopathology in Hyperlipidemic Rats [0.03%]
褪黑素改善高脂血症模型大鼠血脂水平及肝组织病理损伤的作用研究
Ana Cláudia Carvalho de Sousa,Jaiurte Gomes Martins da Silva,Érique Ricardo Alves et al.
Ana Cláudia Carvalho de Sousa et al.
Hyperlipidemia or dyslipidemia is the term used for the increase in lipid levels in blood plasma, usually occurring due to a high-fat diet associated with a sedentary lifestyle. The increase in lipid levels can cause fatty infiltration in t...