Recombinant bispecific monoclonal antibodies prepared by the dock-and-lock strategy for pretargeted radioimmunotherapy [0.03%]
用于放射免疫治疗的“对接和锁定”策略制备的重组双特异性单克隆抗体
Robert M Sharkey,Edmund A Rossi,William J McBride et al.
Robert M Sharkey et al.
The selective delivery of therapeutic radionuclides is a promising approach for treating cancer. Antibody-targeted radionuclides are of particular interest, with 2 products approved for the treatment of certain forms of non-Hodgkin lymphoma...
Smitha Reddy,Matthew K Robinson
Smitha Reddy
Positron emission tomography (PET) is playing an increasingly important role in the diagnosis, staging, and monitoring response to treatment in a variety of cancers. Recent efforts have focused on immuno-PET, which uses antibody-based radio...
Antibody vectors for imaging [0.03%]
抗体载体用于成像
Tove Olafsen,Anna M Wu
Tove Olafsen
Noninvasive molecular imaging approaches include nuclear, optical, magnetic resonance imaging, computed tomography, ultrasound, and photoacoustic imaging, which require accumulation of a signal delivered by a probe at the target site. Monoc...
Antibodies and peptides in nuclear medicine imaging and therapy. Letter from the editors [0.03%]
核医学影像和治疗中的抗体和肽. 编者按
Leonard M Freeman,M Donald Blaufox
Leonard M Freeman
131I-metaiodobenzylguanidine therapy of neuroblastoma and other neuroendocrine tumors [0.03%]
131I-MIBG治疗神经母细胞瘤及其他神经内分泌肿瘤
Frank Grünwald,Samer Ezziddin
Frank Grünwald
Treatment with (131)I-metaiodobenzylguanidine (MIBG) has been introduced to the management of neuroendocrine tumors (NET) nearly 30 years ago. It provides efficient internal radiotherapy of chromaffin tumors (neuroblastoma, pheochromocytoma...
Update on recent developments in the therapy of differentiated thyroid cancer [0.03%]
分化型甲状腺癌治疗近期进展举要
Marcus Middendorp,Frank Grünwald
Marcus Middendorp
In the past decade, the management of differentiated thyroid carcinoma changed significantly and thus contributed to the improvement of the already favorable prognosis of this malignant disease. Surgical treatment techniques improved and th...
Dose intensified molecular targeted radiotherapy for cancer-lymphoma as a paradigm [0.03%]
强化剂量的分子靶向放射治疗作为肿瘤淋巴瘤治疗的新范例
Gerald DeNardo,Sally DeNardo
Gerald DeNardo
Although most patients with locoregional cancer are cured by surgery, radiotherapy, chemotherapy, and combinations thereof, those with distant metastases are not despite systemic chemotherapy. These patients respond to local radiotherapy bu...
Stanley J Goldsmith
Stanley J Goldsmith
Radioimmunotherapy is a form of targeted radionuclide therapy that uses a monoclonal antibody to deliver localized radiation. It is most appropriate for treatment of multiple tumor sites that cannot be readily excised surgically or irradiat...
Hojjat Ahmadzadehfar,Hans-Jürgen Biersack,Samer Ezziddin
Hojjat Ahmadzadehfar
Radioembolization (RE), also termed selective internal radiation therapy (SIRT), has been gradually introduced to the clinical arsenal of cytoreductive modalities in recent years. There is growing evidence for efficiency in liver tumors of ...
Systemic metabolic radiopharmaceutical therapy in the treatment of metastatic bone pain [0.03%]
系统代谢性放射药物治疗转移性骨痛
Fabio M Paes,Aldo N Serafini
Fabio M Paes
Bone pain due to skeletal metastases constitutes the most common type of chronic pain among patients with cancer. It significantly decreases the patient's quality of life and is associated with comorbidities, such as hypercalcemia, patholog...