Elizabeth A Krupinski
Elizabeth A Krupinski
The accurate and efficient interpretation of medical images relies on a host of factors. Clearly the technologies and methods used to acquire, process, transmit, store, and display the image and associated data are critical, but they are on...
Lionel S Zuckier
Lionel S Zuckier
Leonard M Freeman,M Donald Blaufox
Leonard M Freeman
Amala Chirumamilla,Mark I Travin
Amala Chirumamilla
Cardiac autonomic innervation plays a key role in maintaining hemodynamic and electrophysiologic harmony. Cardiac sympathetic function is adversely altered in many disease states, such as congestive heart failure, myocardial ischemia, and d...
Targeted systemic radiotherapy of pheochromocytoma and medullary thyroid cancer [0.03%]
嗜铬细胞瘤和甲状腺髓样癌的靶向系统放射治疗
Chaitanya Divgi
Chaitanya Divgi
Targeted systemic radiotherapy constitutes the systemic administration of a radioactive agent that targets a molecule expressed preferentially on cancer cells. The archetypal such therapy is 131-iodine ((131)I) therapy for differentiated th...
Current role of metaiodobenzylguanidine in the diagnosis of pheochromocytoma and medullary thyroid cancer [0.03%]
当前123碘代间位碘苯基季胺在嗜铬细胞瘤和甲状腺髓样癌诊断中的作用
Ioannis Ilias,Chaitanya Divgi,Karel Pacak
Ioannis Ilias
Despite early reports of excellent diagnostic characteristics of [(131)I]/[(123)I]-metaiodobenzylguanidine (MIBG) in the evaluation of pheochromocytomas/paragangliomas (PHEOs/PGLs) or medullary thyroid cancer as experience with it was accum...
Iodine-131-labeled meta-iodobenzylguanidine therapy of children with neuroblastoma: program planning and initial experience [0.03%]
131I标记的间位碘苯基呱䂒治疗神经母细胞瘤患儿的方案设计及初步体会
Suzanne Shusterman,Frederick D Grant,William Lorenzen et al.
Suzanne Shusterman et al.
Patients with high-risk neuroblastoma have a poor prognosis, especially in cases of recurrent or relapsed disease. Iodine-131-labeled meta-iodobenzylguanidine ((131)I-MIBG) can be an effective and relatively well-tolerated agent for the tre...
Susan E Sharp,Michael J Gelfand,Barry L Shulkin
Susan E Sharp
Neuroblastoma is the most common pediatric extracranial soft-tissue tumor, accounting for approximately 8% of childhood malignancies. Its prognosis is widely variable, ranging from spontaneous regression to fatal disease despite multimodali...
Preclinical assessment of strategies for enhancement of metaiodobenzylguanidine therapy of neuroendocrine tumors [0.03%]
神经内分泌肿瘤间苯二酚碘苯基瓜氨酸治疗增强策略的临床前评估
Rob J Mairs,Marie Boyd
Rob J Mairs
By virtue of its high affinity for the norepinephrine transporter (NET), [(131)I]metaiodobenzylguanidine ([(131)I]MIBG) has been used for the therapy of tumors of neuroectodermal origin for more than 25 years. Although not yet universally a...
Radioiodinated metaiodobenzylguanidine (MIBG): radiochemistry, biology, and pharmacology [0.03%]
放射性碘标记的间位碘代苯基肾上腺素能神经毒(MIBG)：放射化学、生物学及药理学
Shankar Vallabhajosula,Anastasia Nikolopoulou
Shankar Vallabhajosula
As an analogue of adrenergic neurotransmitter norepinephrine (NE), metaiodobenzylguanidine (MIBG) demonstrates high uptake both in normal sympathetically innervated tissues, such as the heart and salivary glands, and in tumors that express ...