Aruna V Krishnan,Donald L Trump,Candace S Johnson et al.
Aruna V Krishnan et al.
Calcitriol (1,25-dihydroxyvitamin D(3)), the hormonally active form of vitamin D, exerts growth inhibitory and prodifferentiating effects on many malignant cells and retards tumor growth in animal models. Calcitriol is being evaluated as an...
Michael F Holick
Michael F Holick
Vitamin D deficiency is the most common nutritional deficiency and likely the most common medical condition in the world. The major cause of vitamin D deficiency has been the lack of appreciation that the body requires 5- to 10-fold higher ...
Martin Hewison
Martin Hewison
Interaction with the immune system is one of the most well-established nonclassic effects of vitamin D. For many years this was considered to be a manifestation of granulomatous diseases such sarcoidosis, in which synthesis of active 1,25-d...
Vitamin D in kidney disease: pathophysiology and the utility of treatment [0.03%]
维生素D在肾病中的病理生理和治疗作用
Rizwan A Qazi,Kevin J Martin
Rizwan A Qazi
Vitamin D physiology has gained more importance and publicity than any of its counterparts in the water- and fat-soluble vitamin groups combined. This is partly because vitamin D deficiency is still widely prevalent in the developed world a...
Heike A Bischoff-Ferrari
Heike A Bischoff-Ferrari
This article discusses the amount of vitamin D supplementation needed and the desirable 25-hydroxyvitamin D level to be achieved for optimal fracture prevention. ...
Peter J Malloy,David Feldman
Peter J Malloy
Two rare genetic diseases can cause rickets in children. The critical enzyme to synthesize calcitriol from 25-hydroxyvitamin D, the circulating hormone precursor, is 25-hydroxyvitamin D-1alpha-hydroxylase (1alpha-hydroxylase). When this enz...
Arti Bhan,Ajay D Rao,D Sudhaker Rao
Arti Bhan
Osteomalacia is an end-stage bone disease of chronic and severe vitamin D or phosphate depletion of any cause. Its importance has increased because of the rising incidence of vitamin D deficiency. Yet, not all cases of osteomalacia are cure...
Maternal vitamin D status: implications for the development of infantile nutritional rickets [0.03%]
母体维生素D状况对婴幼儿营养性佝偻病的影响
Kebashni Thandrayen,John M Pettifor
Kebashni Thandrayen
The mother is the major source of circulating 25-hydroxyvitamin D concentration in the young infant. Maternal vitamin D status is an important factor in determining the vitamin D status of the infant and their risk of developing vitamin D d...
Low vitamin D status: definition, prevalence, consequences, and correction [0.03%]
低维生素D状态：定义、流行病学、影响及干预措施
Neil Binkley,Rekha Ramamurthy,Diane Krueger
Neil Binkley
Vitamin D is obtained from cutaneous production when 7-dehydrocholesterol is converted to vitamin D(3) (cholecalciferol) by ultraviolet B radiation or by oral intake of vitamin D(2) (ergocalciferol) and D(3). An individual's vitamin D statu...
Assessment and interpretation of circulating 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in the clinical environment [0.03%]
临床环境中循环25-羟基维生素D和1,25-二羟基维生素D的评估与解读
Bruce W Hollis
Bruce W Hollis
The unique cis-triene structure of vitamin D and related metabolites makes it susceptible to oxidation, ultraviolet (UV) light-induced conformational changes, heat-induced conformational changes, and attacks by free radicals. Vitamin D(2) i...