Josef Neu,Graciela Lorca,Sandra D K Kingma et al.
Josef Neu et al.
This article discusses recent evidence that associates the developing intestinal microbiome to the pathogenesis of autoimmune T1D. It attempts to identify avenues that should be pursued that relate this new evidence to interventions that ev...
Terri C Thayer,S Brian Wilson,Clayton E Mathews
Terri C Thayer
In 1922, Leonard Thompson received the first injections of insulin prepared from the pancreas of canine test subjects. From pancreatectomized dogs to the more recent development of animal models that spontaneously develop autoimmune syndrom...
Michael J Haller,Mark A Atkinson,Desmond A Schatz
Michael J Haller
Despite improvements in understanding of the natural history of type 1 diabetes (T1D), an intervention capable of consistently and safely preventing or reversing the disease has not been developed. The inability to cure this disorder is lar...
Ezio Bonifacio,Anette G Ziegler
Ezio Bonifacio
Type 1 diabetes (T1D) has the hallmark characteristics of autoimmunity superimposed on genetic susceptibility. Both genes (HLA) and immune markers (autoantibodies) have been validated as predictive markers of the subsequent development of t...
Betty T Tao,David G Taylor
Betty T Tao
This article reviews economic methodologies developed for estimating cost of illness, examines the current literature on diabetes costs, and presents the latest estimates of the economic impact of type 1 diabetes in terms of direct medical ...
David M Maahs,Nancy A West,Jean M Lawrence et al.
David M Maahs et al.
This article describes the epidemiology of type 1 diabetes mellitus (T1D) around the world and across the lifespan. Epidemiologic patterns of T1D by demographic, geographic, biologic, cultural, and other factors in populations are presented...
Type I diabetes. Preface [0.03%]
1型糖尿病前言
Desmond A Schatz,Michael J Haller,Mark A Atkinson
Desmond A Schatz
Type I diabetes. Foreword [0.03%]
1型糖尿病。前言
Derek LeRoith
Derek LeRoith
Vitamin D analogs [0.03%]
维生素D类似物
Glenville Jones
Glenville Jones
Vitamin D has gone through a renaissance with the association of vitamin D deficiency with a wide array of common diseases including breast, colorectal and prostate cancers, cardio-vascular disease, autoimmune conditions and infections. Vit...
Tatiana Takiishi,Conny Gysemans,Roger Bouillon et al.
Tatiana Takiishi et al.
Type 1 (T1D) and type 2 (T2D) diabetes are considered multifactorial diseases in which both genetic predisposition and environmental factors participate in their development. Many cellular, preclinical, and observational studies support a r...