Multicenter clinical trials in sepsis: understanding the big picture and building a successful operation at your hospital [0.03%]
脓毒症多中心临床试验：把握整体情况和在医院内顺利开展
R Phillip Dellinger,Christa Schorr,Stephen Trzeciak
R Phillip Dellinger
Only through adequately designed and adequately conducted clinical trials can new treatments be found for the benefit of the septic patient. Over the past 20 years, tens of thousands of patients have been enrolled in sepsis clinical trials ...
Christa Schorr
Christa Schorr
Sepsis guidelines, although creating a base to allow change in health care practitioner behavior, do not, in and of themselves, effect change. Change only comes with institution of a PI program, converting a core of key goals of guideline r...
Allen Namath,Andrew J Patterson
Allen Namath
The number of genetic polymorphisms shown to play a role in sepsis continues to increase. At the same time, platforms for genetic sequencing and expression analysis are being refined, allowing unprecedented data generation. International da...
Charles L Sprung,Serge Goodman,Yoram G Weiss
Charles L Sprung
Steroid therapy in patients with septic shock has been controversial for decades. Although treatment with high-doses of corticosteroids for patients with septic shock has been shown not to be beneficial, it was believed that therapy with lo...
Brian Casserly,Richard Read,Mitchell M Levy
Brian Casserly
Arterial waveform analysis that does not require continuous calibration, impedance cardiography, electrical cardiometry, velocity-encoded phase contrast magnetic resonance imaging (MRI), pulsed dye densitometry, noninvasive pulse pressure a...
Steven M Hollenberg
Steven M Hollenberg
The ultimate goals of hemodynamic therapy in shock are to restore effective tissue perfusion and to normalize cellular metabolism. In sepsis, both global and regional perfusion must be considered. In addition, mediators of sepsis can pertur...
Alan E Jones,Michael A Puskarich
Alan E Jones
The understanding of sepsis is continuously evolving. An overview of sepsis-induced tissue hypoperfusion has been provided herein. It is of critical importance that the clinician understands the pathophysiology of this emergent condition an...
John C Marshall,Abdullah Al Naqbi
John C Marshall
This brief overview of the role of source control in sepsis emphasizes the underlying principles rather than the empiric evidence from well-performed clinical studies. The reasons for this are several. First there is a paucity of high-level...
Anand Kumar
Anand Kumar
Every patient with sepsis and septic shock must be evaluated thoroughly at presentation before the initiation of antibiotic therapy. However, in most situations, an abridged initial assessment focusing on critical diagnostic and management ...
David J Lundy,Stephen Trzeciak
David J Lundy
Septic shock is a common and deadly disease that traditionally has been diagnosed and treated by evaluation and optimization of global hemodynamic indices. However, microcirculatory dysfunction is a critically important element in the patho...