H. Ralph Schumacher [0.03%]
赫尔伯特·拉尔夫·舒马赫
Joshua F Baker,Daniel G Baker
Joshua F Baker
Dr Schumacher was a force in rheumatology for more than half a century through his multiple roles as a researcher, clinician, mentor, and educator. He is not likely to be soon forgotten by the rheumatology community; however, it is hoped th...
Arthur Weinstein
Arthur Weinstein
Naomi Rothfield was truly a pied piper of lupus. She had an abiding interest in the characterization and clinical significance of antinuclear antibodies and anti-DNA antibodies in the serum of systemic lupus erythematosus (SLE) patients. Sh...
Erin Janssen
Erin Janssen
Michael H Weisman
Michael H Weisman
Smriti Mohan
Smriti Mohan
Increasing molecular knowledge of autoinflammatory and autoimmune disorders has enabled more targeted treatment of these conditions. Treatment of inflammasomopathies is often aimed at interleukin-1 (IL-1) blockade, with potential use of oth...
Molecular Pathways in the Pathogenesis of Systemic Juvenile Idiopathic Arthritis [0.03%]
系统性幼年型关节炎发病机制中的分子通路
Grant S Schulert,Christoph Kessel
Grant S Schulert
Systemic juvenile idiopathic arthritis (sJIA) is a rare childhood chronic inflammatory disorder with risk for life-threatening complications including macrophage activation syndrome and lung disease. At onset, sJIA pathogenesis resembles th...
Mechanisms and Emerging Therapies for Treatment of Seizures in Pediatric Autoimmune Encephalitis and Autoinflammatory/Autoimmune-Associated Epilepsy [0.03%]
儿科自身免疫性脑炎和自身炎症/自身免疫相关癫痫的发病机制及治疗新方法
Milena M Andzelm,Coral M Stredny
Milena M Andzelm
There has been increasing understanding of the role of inflammation in seizures and epilepsy, as well as targeted immunomodulatory treatments. In children, immune-mediated seizures often present acutely in the setting of autoimmune encephal...
Atiye Olcay Bilgic Dagci,Kelly Colleen Cushing
Atiye Olcay Bilgic Dagci
Inflammatory bowel disease (IBD) represents a spectrum of disease, which is characterized by chronic gastrointestinal inflammation. Monogenic mutations driving IBD pathogenesis are more highly represented in early-onset compared to adult-on...
Understanding the Spectrum of Immune Dysregulation Manifestations in Autoimmune Lymphoproliferative Syndrome and Autoimmune Lymphoproliferative Syndrome-like Disorders [0.03%]
对自身免疫性淋巴增生综合征及其类似障碍所表现出的免疫调节异常谱系的理解
Christopher Failing,Jennifer R Blase,Kelly Walkovich
Christopher Failing
As a disorder of immune dysregulation, autoimmune lymphoproliferative syndrome (ALPS) stems from pathogenic variants in the first apoptosis signal-mediated apoptosis (Fas) and Fas-ligand pathway that result in elevations of CD3+ TCRαβ+ CD...
Holly Wobma,Erin Janssen
Holly Wobma
Regulatory T cells (Tregs) are critical for enforcing peripheral tolerance. Monogenic "Tregopathies" affecting Treg development, stability, and/or function commonly present with polyautoimmunity, atopic disease, and infection. While autoimm...